Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

Iores-Marçal, Lígia M.; Viel, Tânia Araújo; Buck, Hudson Sousa; Nunes, Viviane Abreu; Gozzo, Andrezza Justino; Cruz-Silva, Ilana; Miranda, Antônio; Shimamoto, Kazuaki; Ura, Nobuyuki; Araújo, Magali

doi:10.1016/j.peptides.2006.08.012

Cited by 35 publications

(22 citation statements)

References 26 publications

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“…However, in those works, the doses used were at least 32 times higher (0.159 nmol/μL to 2,0 nmol/ μL) than the dose used in the present work (0.005 nmol/μL) and the researchers made a single injection (or three single injections) of the Aβ (1–40 or 1–42), and not a chronic infusion [47,48,49,50,51]. In previous works, our research team observed neuron degeneration in the cortex and hippocampus and loss of memory in animals infused with 0.005 nmol/μL [18,19,29,52]. But in the present work, we verified that the observed loss of memory was not followed by increases in the AChE activity.…”

Section: Resultsmentioning

confidence: 65%

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Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

et al. 2016

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Alzheimer’s disease is a chronic and degenerative condition that had no treatment until recently. The current therapeutic strategies reduce progression of the disease but are expensive and commonly cause side effects that are uncomfortable for treated patients. Functional foods to prevent and/or treat many conditions, including neurodegenerative diseases, represent a promising field of study currently gaining attention. To this end, here we demonstrate the effects of pomegranate (Punica granatum) peel extract (PPE) regarding spatial memory, biomarkers of neuroplasticity, oxidative stress and inflammation in a mouse model of neurodegeneration. Male C57Bl/6 mice were chronically infused for 35 days with amyloid-β peptide 1–42 (Aβ) or vehicle (control) using mini-osmotic pumps. Another group, also infused with Aβ, was treated with PPE (p.o.– βA+PPE, 800 mg/kg/day). Spatial memory was evaluated in the Barnes maze. Animals treated with PPE and in the control group exhibited a reduction in failure to find the escape box, a finding that was not observed in the Aβ group. The consumption of PPE reduced amyloid plaque density, increased the expression of neurotrophin BDNF and reduced the activity of acetylcholinesterase enzyme. A reduction in lipid peroxidation and in the concentration of the pro-inflammatory cytokine TNF-α was also observed in the PPE group. No hepatic lesions were observed in animals treated with PPE. In conclusion, administration of pomegranate peel extract has neuroprotective effects involving multiple mechanisms to prevent establishment and progression of the neurodegenerative process induced by infusion with amyloid-β peptide in mice.

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Section: Resultsmentioning

confidence: 65%

“…It is possible that the decrease in memory, as determined by the increase in the number of errors to find the escape box in the Aβ group, is related to neurodegeneration in the cortex and hippocampus caused by chronic infusion with Aβ peptide [17,29] and formation of senile plaques in these brain areas [18]. …”

Section: Resultsmentioning

confidence: 99%

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

et al. 2016

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“…Our group showed significant neuronal loss and amyloid deposit formation in the cortex and the hippocampus and an increase in kinin concentration in the cerebrospinal fluid in rats infused with human 1-40 Aβ peptide (Iores-Marçal et al, 2006), suggesting an enhanced activation of the kallilkrein-kinin-system (KKS) (Iores-Marçal et al, 2006). Moreover, we showed a disruption in memory consolidation of rats submitted to the same protocol, accompanied by an increase in B1R densities in the ventral hippocampal commissure, fimbria, CA1 and CA3 hippocampal areas, habenular nuclei and optical tract, when compared to the correlated areas in the control group.…”

Section: Introductionmentioning

confidence: 67%

Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease

Caetano¹,

Dong-Creste²,

Amaral³

et al. 2015

Neuropeptides

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“…of rats and humans (Bhoola et al, 1992;Li et al, 1999). Moreover, in AD transgenic animals, Aβ increases kinin concentration in the cerebrospinal fluid (CSF) and also increases bradykinin B 1 and B2 receptor densities in brain areas related to memory (Viel et al, 2008;Iores-Marcal et al, 2006). Bradykinin is an agonist of B 2 receptors and signals primarily through this receptor.…”

Section: Tablementioning

confidence: 99%

Differential regulation of astrocyte prostaglandin response by kinins: Possible role for mitogen activated protein kinases

Torika

Filipovich-Rimon

Asraf

et al. 2014

European Journal of Pharmacology

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Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease

Cited by 35 publications

References 26 publications

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease

Differential regulation of astrocyte prostaglandin response by kinins: Possible role for mitogen activated protein kinases

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