Bradykinin releases acetylcholine from myenteric plexus by a prostaglandin-mediated mechanism

Yau, William M.; Dorsett, J. A.; Youther, Michael L.

doi:10.1016/0196-9781(86)90227-5

Cited by 25 publications

(16 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, it has been reported that BK can release acetylcholine from longitudinal muscle-myenteric plexus preparations (Goldstein et al, 1983). Also, Yau et al (1986) presented results that BK-induced release of [3H]-acetylcholine from the preparation is sensitive to indomethacin, implying that this kinin effect was dependent upon stimulation of prostaglandin biosynthesis. In as much as carbachol produced a very large increase in [3H]-IP1 levels in the slice preparation used in the present experiments, we examined the possibility that the BK response is linked to either prostaglandin biosynthesis or the release of endogenous acetylcholine which would then activate smooth muscle phosphoinositide-linked muscarinic receptors.…”

Section: Radioreceptor Assaymentioning

confidence: 86%

“…Yet the results of Yau et al (1986) indicate that BK receptors are also coupled to prostaglandin biosynthesis in longitudinal muscle-myenteric plexus preparations. Inasmuch as only a single binding site was detected, either the receptors associated with the two transduction mechanisms are pharmacologically identical or one may not be detectable in the binding assay, possibly because of low density.…”

Section: Radioreceptor Assaymentioning

confidence: 99%

“…Also, one study has indicated that BK-induced release of acetylcholine is an indirect action that follows increased prostanoid biosynthesis (Yau et al, 1986). As such, the possible contribution of these mechanisms to the BK phosphoinositide response were evaluated.…”

Section: Radioreceptor Assaymentioning

confidence: 99%

See 2 more Smart Citations

Bradykinin stimulation of phosphoinositide hydrolysis in guinea‐pig ileum longitudinal muscle

Ransom

Goodman

Young

1992

British J Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Radioreceptor Assaymentioning

confidence: 86%

Section: Radioreceptor Assaymentioning

confidence: 99%

See 1 more Smart Citation

Bradykinin stimulation of phosphoinositide hydrolysis in guinea‐pig ileum longitudinal muscle

Ransom

Goodman

Young

1992

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…In addition to its well-documented effects in the periphery, bradykinin may also act as a modulator or/and neurotransmitter in the central nervous system (CNS;Snyder 1980;Yaksh and Hammond 1982;Yano et al, 1984;Yau et al, 1986). The biological effects of bradykinin are mediated by its interactions with two distinct bradykinin receptor subtypes, the bradykinin B1 and B2 receptors.…”

Section: Indexing Terms: Bradykinin; Kininogen; Immunohistochemistrymentioning

confidence: 97%

B2 bradykinin receptor immunoreactivity in rat brain

et al. 2000

View full text Add to dashboard Cite

Bradykinin has long been known to exist in the central nervous system and has been hypothesized to mediate specific functions. Despite an increasing understanding of the functions of bradykinin, little is known about the cell types expressing the bradykinin receptor within the brain. The present investigation employed a monoclonal antibody directed against the 15-amino-acid portion of the C-terminal of the human bradykinin B2 receptor to establish the cellular distribution of bradykinin B2 receptor immunoreactivity in the rat brain. Bradykinin B2 receptor immunoreactivity was ubiquitously and selectively observed in neurons, including those within the olfactory bulb, cerebral cortex, hippocampus, basal forebrain, basal ganglia, thalamus, hypothalamus, cerebellum, and brainstem nuclei. Bradykinin B2 receptor immunoreactivity was also present in the circumventricular organs including choroid plexus, subfornical organ, median eminence, and area postrema. Double-labeling experiments colocalizing the bradykinin B2 receptor with the neuronal marker NeuN or the astrocytic marker glial fibrillary acidic protein revealed that virtually 100% of the bradykinin B2 receptor-immunoreactive positive cells were neurons. The widespread distribution of bradykinin B2 receptor immunoreactivity in neuronal compartments suggests a greater than previously appreciated role for this peptide in neuronal function.

show abstract

“…It has been reported that bradykinin enhances the release of [ 3 H]‐acetylcholine from cholinergic nerves in the guinea pig myenteric plexus (Yau et al , 1986). Moreover, Omini et al (1989) postulated that bradykinin may potentiate parasympathetic activity by increasing neurotransmitter release from vagal nerves.…”

Section: Discussionmentioning

confidence: 99%

Interaction of the renin–angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea

Fabiani

Dinh

Story

1997

British J Pharmacology

View full text Add to dashboard Cite

1 The present study was undertaken to investigate the interaction of the renin ± angiotensin system (RAS), bradykinin and the sympathetic nervous system with cholinergic transmission in the rat airways. Experiments were performed on epithelium-intact and epithelium-denuded preparations of rat isolated trachea which had been incubated with [ 3 H]-choline to incorporate [ 3 H]-acetylcholine into the cholinergic transmitter stores. Tracheal preparations were subjected to electrical ®eld stimulation (trains of 1 ms pulses, 5 Hz, 15 V) and the stimulation-induced (S-I) e ux taken as an index of transmitter acetylcholine release. 2 In both epithelium-intact and epithelium-denuded tracheal preparations, the a 2 -adrenoceptor agonist UK14304 (0.1 and 1 mM) inhibited the S-I e ux, in a concentration-dependent manner. The inhibition of S-I e ux produced by UK14304 (1 mM) was antagonized by the selective a 2 -adrenoceptor antagonist idazoxan (0.3 mM). Idazoxan (0.3 mM) alone had no e ect on the S-I e ux. 3 Angiotensin II (0.1 and 1 mM) was without e ect on the S-I e ux in either epithelium-intact or epithelium-denuded tracheal preparations. When angiotensin-converting enzyme was inhibited by perindoprilat (10 mM), angiotensin II (1 mM) was also without e ect on the S-I e ux. Similarly, in the presence of idazoxan (0.3 mM), to block prejunctional a 2 -adrenoceptors, angiotensin II (0.1 and 1 mM) did not alter the S-I e ux. When added alone, perindoprilat (10 mM) did not alter the S-I e ux. 4 In epithelium-denuded preparations, bradykinin (0.01 ± 1 mM) inhibited the S-I e ux. In epitheliumintact preparations, there was also a tendency for bradykinin (0.1 and 1 mM) to inhibit the S-I e ux but this was not statistically signi®cant. However, when angiotensin-converting enzyme and neutral endopeptidase were inhibited by perindoprilat (10 mM) and phosphoramidon (1 mM), respectively, bradykinin (1 mM) signi®cantly inhibited the S-I e ux in epithelium-intact preparations as well as in epithelium-denuded preparations. The inhibition of the S-I e ux produced by bradykinin, in the combined presence of perindoprilat (10 mM) and phosphoramidon (1 mM), was una ected by the additional presence of the cyclo-oxygenase inhibitor indomethacin (10 mM) and/or the nitric oxide synthase inhibitor N G -nitro-L-arginine (100 mM), in either epithelium-intact or epithelium-denuded preparations. 5 In conclusion, the ®ndings of the present study suggest that airway parasympathetic nerves are endowed with a 2 -adrenoceptors which subserve inhibition of transmitter acetylcholine release. Under the present conditions, however, transmitter acetylcholine release is not subject to transneuronal modulation by noradrenaline released from adjacent sympathetic nerves in the airways. Moreover, angiotensin II and perindoprilat do not appear to modulate acetylcholine release from parasympathetic nerves of the airways. In contrast, bradykinin inhibits acetylcholine release from airway parasympathetic nerves but this action of bradykinin is limited by the activity of...

show abstract

Bradykinin releases acetylcholine from myenteric plexus by a prostaglandin-mediated mechanism

Cited by 25 publications

References 10 publications

Bradykinin stimulation of phosphoinositide hydrolysis in guinea‐pig ileum longitudinal muscle

Bradykinin stimulation of phosphoinositide hydrolysis in guinea‐pig ileum longitudinal muscle

B2 bradykinin receptor immunoreactivity in rat brain

Interaction of the renin–angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea

Contact Info

Product

Resources

About