2021
DOI: 10.3390/ijms222312724
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BRAF Mutation Is Associated with Hyperplastic Polyp-Associated Gastric Cancer

Abstract: Gastric hyperplastic polyps (GHP) are frequently found to be benign polyps and have been considered to have a low carcinogenic potential. The characteristics of the hyperplastic polyp-associated gastric cancer (HPAGC) remain unclear. Therefore, we analyzed samples from 102 GHP patients and identified 20 low-grade atypical GHPs (19.6%), 7 high-grade atypical GHPs (6.9%), and 5 intramucosal cancer samples (4.9%). GHP atypia was more common in the elderly and increased with increasing polyp size. In particular, p… Show more

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Cited by 5 publications
(3 citation statements)
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“…Consecutive 4-μm thick sections were immunohistochemically stained using the immunoperoxidase technique described previously [ 45 ], with the primary antibodies listed in Table 5 and appropriate secondary antibodies (Medical and Biological Laboratories, Nagoya, Japan) (all 0.2 µg/mL). The tissue sections were then color-developed with diamine benzidine hydrochloride (Dako, Glostrup, Denmark) and counterstained with Meyer’s hematoxylin (Sigma-Aldrich Chemical Co., St. Louis, MO, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Consecutive 4-μm thick sections were immunohistochemically stained using the immunoperoxidase technique described previously [ 45 ], with the primary antibodies listed in Table 5 and appropriate secondary antibodies (Medical and Biological Laboratories, Nagoya, Japan) (all 0.2 µg/mL). The tissue sections were then color-developed with diamine benzidine hydrochloride (Dako, Glostrup, Denmark) and counterstained with Meyer’s hematoxylin (Sigma-Aldrich Chemical Co., St. Louis, MO, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Morphologically, GHP ranges in size from a few millimeters to a few centimeters [3], leading to be misdiagnosed as tumor or cancer under endoscopy. Some of patients with GHP may present with dyspepsia, heartburn, abdominal pain, or anemia, but most of them are usually asymptomatic [4], which makes it di cult to be diagnosed in advance. GHP was considered to be a non-tumor lesion previously [5].…”
Section: Introductionmentioning
confidence: 99%
“…Morphologically, GHP ranges in size from a few millimeters to a few centimeters, [3] leading to be misdiagnosed as tumor or cancer under endoscopy. Some of patients with GHP may present with dyspepsia, heartburn, abdominal pain, or anemia, but most of them are usually asymptomatic, [4] which makes it difficult to be diagnosed in advance. GHP was considered to be a non-tumor lesion previously.…”
Section: Introductionmentioning
confidence: 99%