Brain 3D-echographic early predictors of neuro-behavioral disorders in infants: a prospective observational study

Aisa, Maria Cristina; Barbati, Antonella; Gerli, Sandro; Clerici, Graziano; Nikolova, Natasha; Giardina, Irene; Babucci, Giulia; Rosa, Francesca; Cappuccini, Benito

doi:10.1080/14767058.2020.1730323

Cited by 11 publications

(20 citation statements)

References 48 publications

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“…Preterm birth per se as well as brain injuries such as fetal growth restriction [ 8 ], intraventricular hemorrhages [ 9 ], oxygen toxicity [ 10 ], neonatal stroke [ 11 ], or inflammatory events [ 12 ] may well interrupt brain development and maturation as independent risk factors or in combination and seem to be causative for adverse neuronal developmental disorders. There is a strong correlation between prematurity and a worse prognosis for the development of neurological impairments [ 13 ], but also for reduced regional brain volumes [ 14 , 15 ]. Decreased cerebellar volumes and delayed growth are associated with noxious perinatal and postnatal factors [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats

Giszas

Strauss

Bührer

et al. 2022

Oxidative Medicine and Cellular Longevity

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Preterm birth disrupts cerebellar development, which may be mediated by systemic oxidative stress that damages neuronal developmental stages. Impaired cerebellar neurogenesis affects several downstream targets important for cognition, emotion, and speech. In this study, we demonstrate that oxidative stress induced with high oxygen (80%) for three or five postnatal days (P3/P5) could significantly damage neurogenesis and proliferative capacity of granular cell precursor and Purkinje cells in rat pups. Reversal of cellular neuronal damage after recovery to room air (P15) was augmented by treatment with caffeine. However, downstream transcripts important for migration and differentiation of postmitotic granular cells were irreversibly reduced by hyperoxia, without rescue by caffeine. Protective effects of caffeine in the cerebellum were limited to neuronal survival but failed to restore important transcript signatures.

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Section: Introductionmentioning

confidence: 99%

The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats

Giszas

Strauss

Bührer

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Many studies in the literature have used Griffiths scales to assess the psychomotor development of preterm infants at early ages [8,[18][19][20][21][22], but there are few data analysing the longitudinal development of the cognitive functions at 12 and 24 months and or at preschool age in those at low risk [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Although the cognitive development of very preterm infants has been widely studied both in infancy and at school age [5][6][7][8], only a few studies have reported information on longitudinal assessments [9,10], especially in low-risk preterm infants.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Cognitive Assessment in Low-Risk Very Preterm Infants

et al. 2022

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Background and Objectives: Preterm infants are at higher risk of neurodevelopmental impairment both at preschool and school ages, even in the absence of major neurological deficits. The early identification of children at risk is essential for early intervention with rehabilitation to optimize potential outcomes during school years. The aim of our study is to assess cognitive outcomes at preschool age in a cohort of low-risk very preterm infants, previously studied at 12 and 24 months using the Griffiths scales. Materials and Methods: Sixty-six low-risk very preterm infants born at a gestational age of <32 weeks were assessed at 12 and 24 months corrected age using the Griffiths Mental Development Scales (second edition) and at preschool age with the Wechsler Preschool and Primary Scales of Intelligence (third edition) (WPPSI-III). Results: At 12 and 24 months and at preschool age, low-risk very preterm infants showed scores within normal ranges with similar scores in males and females. A statistically significant correlation was observed in the general developmental quotient between 12 and 24 months; a further significant correlation was observed between the early cognitive assessments and those performed at preschool age, with a better correlation using the assessments at 24 months. Conclusion: The present study showed a favourable trajectory of cognitive development in low-risk very preterm infants, from 12 months to preschool age.

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“…Postnatally, cerebral ultrasound sonography is commonly used to monitor brain development in the first few weeks of life after IUGR. A recent study by Aisa and colleagues suggests the additional use of 3D ultrasound sonography to detect changes in brain volume as an early indicator of neurodevelopmental disorders [ 98 ]. Further studies on changes of cerebral morphology after IUGR have been reviewed by Dudink et al [ 99 ].…”

Section: Follow-up Care Of Children “At Risk” After Iugr Using the Ex...mentioning

confidence: 99%

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

Nüsken,

Appel,

Saschin

et al. 2024

Cells

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Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is below the tenth percentile. IUGR can be identified by additional abnormalities (pathological Doppler sonography, oligohydramnion, lack of growth in the interval, estimated weight below the third percentile) and can also be present in fetuses and neonates with weights above the tenth percentile. There is a need to differentiate between IUGR and SGA whenever possible, as IUGR in particular is associated with greater perinatal morbidity, prematurity and mortality, as well as an increased risk for diseases in later life. Recognizing fetuses and newborns being “at risk” in order to monitor them accordingly and deliver them in good time, as well as to provide adequate follow up care to ameliorate adverse sequelae is still challenging. This review article discusses approaches to differentiate IUGR from SGA and further increase diagnostic accuracy. Since adverse prenatal influences increase but individually optimized further child development decreases the risk of later diseases, we also discuss the need for interdisciplinary follow-up strategies during childhood. Moreover, we present current concepts of pathophysiology, with a focus on oxidative stress and consecutive inflammatory and metabolic changes as key molecular mechanisms of adverse sequelae, and look at future scientific opportunities and challenges. Most importantly, awareness needs to be raised that pre- and postnatal care of IUGR neonates should be regarded as a continuum.

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Brain 3D-echographic early predictors of neuro-behavioral disorders in infants: a prospective observational study

Cited by 11 publications

References 48 publications

The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats

The Conflicting Role of Caffeine Supplementation on Hyperoxia-Induced Injury on the Cerebellar Granular Cell Neurogenesis of Newborn Rats

Longitudinal Cognitive Assessment in Low-Risk Very Preterm Infants

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

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