Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review

Egbert, Anna Rita; Cankurtaran, Sadiye; Karpiak, Stephen E.

doi:10.1016/j.bbi.2020.07.014

Cited by 101 publications

(95 citation statements)

References 35 publications

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“…We found that white matter abnormalities was the most frequent neuroimaging pattern in patients with COVID-19 and neurological manifestations, which is consistent with a previous review (37). White matter-specific injuries was presented in a case series of six COVID-19 patients who exhibited an altered mental status (38).…”

Section: White Matter Abnormalitysupporting

confidence: 90%

Insights Into Neuroimaging Findings of Patients With Coronavirus Disease 2019 Presenting With Neurological Manifestations

Chen

Zheng

et al. 2020

Front. Neurol.

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Section: White Matter Abnormalitysupporting

confidence: 90%

Insights Into Neuroimaging Findings of Patients With Coronavirus Disease 2019 Presenting With Neurological Manifestations

Chen

Zheng

et al. 2020

Front. Neurol.

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“…Nevertheless, a shortage of brain images on all patients might alter the results. Also, the deeper brain structures, cerebellum, and midline involvement were rarely reported [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Demyelinating Changes Alike to Multiple Sclerosis: A Case Report of Rare Manifestations of COVID-19

Yavari

Raji

Moradi

et al. 2020

Case Reports in Neurological Medicine

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COVID-19, as a global concern and pivotal issue in the healthcare system, could have various presentations, leading to difficulty in diagnosis and management. Neuroinvasive potency, as claimed by preliminary studies, is a considerable pathogenesis. Serious neurological disorders like multiple sclerosis (MS) were out of the blue to be the first demonstration of COVID-19. This report highlights the representation of MS in a young woman, which resulted in a COVID-19 diagnosis.

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“…A recent systematic review that included 26 neuroimaging studies, most of them case series of COVID-19 patients who underwent brain imaging examination due to neurological symptoms, found that 34% (124/361) of the cases presented brain lesions probably attributable to COVID-19 and among them, the most common finding was diffuse subcortical and deep white matter abnormalities. Other common findings, although less prevalent, were microhemorrhages, hemorrhages, and infarcts (Rita Egbert et al, 2020).…”

Section: Mechanisms Involved In Cognitive and Neuropsychiatric Manifementioning

confidence: 94%

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

Alonso‐Lana

Marquié

Ruiz

et al. 2020

Front. Aging Neurosci.

150

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The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide and has had unprecedented effects in healthcare systems, economies and society. COVID-19 clinical presentation primarily affects the respiratory system causing bilateral pneumonia, but it is increasingly being recognized as a systemic disease, with neurologic manifestations reported in patients with mild symptoms but, most frequently, in those in a severe condition. Elderly individuals are at high risk of developing severe forms of COVID-19 due to factors associated with aging and a higher prevalence of medical comorbidities and, therefore, they are more vulnerable to possible lasting neuropsychiatric and cognitive impairments. Several reports have described insomnia, depressed mood, anxiety, post-traumatic stress disorder and cognitive impairment in a proportion of patients after discharge from the hospital. The potential mechanisms underlying these symptoms are not fully understood but are probably multifactorial, involving direct neurotrophic effect of SARS-CoV-2, consequences of long intensive care unit stays, the use of mechanical ventilation and sedative drugs, brain hypoxia, systemic inflammation, secondary effects of medications used to treat COVID-19 and dysfunction of peripheral organs. Chronic diseases such as dementia are a particular concern not only because they are associated with higher rates of hospitalization and mortality but also because COVID-19 further exacerbates the vulnerability of those with cognitive impairment. In patients with dementia, COVID-19 frequently has an atypical presentation with mental status changes complicating the early identification of cases. COVID-19 has had a dramatical impact in long-term care facilities, where rates of infection and mortality have been very high. Community measures implemented to slow the spread of the virus have forced to social distancing and cancelation of cognitive stimulation programs, which may have contributed to generate loneliness, behavioral symptoms and worsening of cognition in patients with dementia. COVID-19 has impacted the functioning of Memory Clinics, research programs and clinical trials in the Alzheimer's field, triggering the

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Brain abnormalities in COVID-19 acute/subacute phase: A rapid systematic review

Cited by 101 publications

References 35 publications

Insights Into Neuroimaging Findings of Patients With Coronavirus Disease 2019 Presenting With Neurological Manifestations

Insights Into Neuroimaging Findings of Patients With Coronavirus Disease 2019 Presenting With Neurological Manifestations

Demyelinating Changes Alike to Multiple Sclerosis: A Case Report of Rare Manifestations of COVID-19

Cognitive and Neuropsychiatric Manifestations of COVID-19 and Effects on Elderly Individuals With Dementia

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