Brain abscess caused by Lactococcus lactis cremoris in a child

Abstract

Lactococcus lactis cremoris infections are very rare in humans. It is recognized as a commensal organism of mucocutaneous surfaces of cattle, and is occasionally isolated from human mucocutaneous surfaces. We report a brain abscess caused by L. lactis cremoris in an immunocompetent child. A 19-month-old female patient was admitted with fever and vomiting. Brain computed tomography (CT) revealed brain abscess. L. lactis cremoris was isolated from culture of the abscess material. The patient was treated with pus drainage from brain abscess and antibiotics including vancomycin and meropenem. The patient recovered completely. To our knowledge, this is the first report of a L. lactis cremoris infection in children.

Lactococcus lactis spp lactis infection in infants with chronic diarrhea: two cases report and literature review in children

“…[ Table 1] The first case is a 19-month-old immunocompetent female child with a brain abscess caused by L. lactis cremoris. The patient was treated with abscess drainage and antibiotic therapy including vancomycin and meropenem and she recovered completely [15]. The second case is a newborn who developed bacterial meningitis and septicemia due to Lactococcus lactis that was successfully treated with vancomycine and cefotaxime without any neurological sequelae [16].…”

Urinary Tract Infection in a Preterm Neonate Caused by Lactococcus lactis

“…It is unknown how the mother acquired L. lactis, as she had no known exposure to cattle, the common host for Lactococcus, or contaminated dairy products. Lactococcus has occasionally been identified as a component of the normal flora in humans 4 ; this may have been a possibility for this mother, as the organism was not pathogenic for her.…”

“…Lactococcus is a genus of facultative anaerobic catalase-negative, gram-positive cocci previously classified as Streptococcus. 2,4 Other strains of Lactococcus have been reported to be susceptible to penicillin, cephalosporins, vancomycin, meropenem, and macrolides. [2][3][4][5] However, in this case, the strain was resistant or intermediately resistant to several antibiotics to which it was expected to be susceptible, including penicillin, amoxicillin, cephalexin, cefixime, and trimethoprim.…”

“…In adults, these infections have included endocarditis, liver abscess, peritonitis, pneumonitis, spondylodiscitis, septic arthritis, osteomyelitis, sepsis, deep neck infection, and brain abscess. [2][3][4] Among pediatric patients, a few cases have been reported, including brain abscess in a 19-month-old child, 4 catheter-related bacteremia in a 9-month-old infant, 5 and meningitis and septicemia in a 16-day-old neonate. 3 This article describes a preterm neonate who experienced a urinary tract infection caused by Lactococcus lactis.…”

Intra-abdominal abscesses by Lactococcus lactis ssp cremoris in an immunocompetent adult with severe periodontitis and pernicious anemia

“…Although Lactococcus lactis was considered to be non-pathogenic, it has been reported to cause human disease in the last two decades, in both immunocompetent and immunocompromised patients [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12].…”