Brain Abscess: Management and Outcome Analysis of a Computed Tomography Era Experience with 973 Patients

Nathoo, Narendra; Nadvi, S S; Narotam, Pradeep K; Dellen, James R. van

doi:10.1016/j.wneu.2010.11.043

Cited by 187 publications

(215 citation statements)

References 31 publications

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“…In a recent retrospective analysis of 973 patients with brain abscess in South Africa, Oto-rhino sources of infection (38%) were the most common, followed by traumatic (32%), pulmonary (7%), and cryptogenic (4%). Operative drainage of abscesses >2.5 cm in diameter and antibiotic therapy resulted in a mortality rate of 13%, a poor outcome in 5%, and a good outcome in 81% of patients [84]. These outcomes are similar in other retrospective studies in Europe and Asia [6,85,86].…”

Section: Bacterial Brain Abscesssupporting

confidence: 77%

Neuro-Intensive Care of Patients with Acute CNS Infections

Beckham

Tyler

2012

Neurotherapeutics

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Summary Infections in the central nervous system (CNS) are caused by a wide range of microorganisms resulting in distinct clinical syndromes including meningitis, encephalitis, and pyogenic infections, such as empyema and brain abscess. Bacterial and viral infections in the CNS can be rapidly fatal and can result in severe disability in survivors. Appropriate identification and acute management of these infections often occurs in a critical care setting and is vital to improving outcomes in this group of patients. This review of diagnosis and management of acute bacterial and viral infections in the CNS provides a general approach to patients with a suspected CNS infection and also provides a more detailed review of the diagnosis and management of patients with suspected bacterial meningitis, viral encephalitis, brain abscess, and subdural empyema.

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Section: Bacterial Brain Abscesssupporting

confidence: 77%

Neuro-Intensive Care of Patients with Acute CNS Infections

Beckham

Tyler

2012

Neurotherapeutics

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“…The common clinical signs and symptoms of brain abscesses are as follows: headache, mental status change, seizure, and focal neurological signs (8)(9)(10)(11). However, these symptoms may be confused with hepatic encephalopathy in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

Increased occurrence of brain abscesses in cirrhotic patients: A population-based 3-year follow-up study

Chen¹,

Hung²,

Tseng³

et al. 2017

Turk J Gastroenterol

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“…In human case series, up to 20% of brain abscesses are multiloculated [11][12][13][14][15]. This is thought to result from poor abscess encapsulation.…”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate in humans with brain abscesses has declined significantly since the advent of CT and is currently between 8 and 25% [15,17]. Abscesses are treated surgically (by excision or drainage) whenever possible; indications to delay or avoid surgical excision include multiple distantly located abscesses, abscesses in deep or vital brain structures, and concurrent meningitis or ependymitis [16,18,19].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of a Chronic Brain Abscess and Growing Skull Fracture in a Dog

Hodshon

Narak

Craig

et al. 2015

Case Reports in Veterinary Medicine

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A 2-year-old female spayed Miniature Dachshund was presented for seizures and right prosencephalic signs. A multiloculated, ring-enhancing mass in the right cerebrum associated with dilation of the right lateral ventricle and brain herniation was seen on magnetic resonance imaging. An irregular calvarial defect with smoothly scalloped edges was seen overlying the mass on computed tomography. The mass was removed via craniectomy and was diagnosed as a chronic brain abscess caused by Peptostreptococcus anaerobius. The patient was maintained on antibiotics for 12 weeks. Follow-up MRI performed 14 weeks after surgery confirmed complete removal of the abscess as well as a contrast-enhancing collection of extra-axial material consistent with a chronic subdural hematoma. The neurologic abnormalities, including seizures, have improved in the 44 months since surgery. Brain abscesses in dogs can have an insidious clinical course prior to causing serious neurologic deterioration. Ventricular entrapment by an intracranial mass can contribute to acute neurologic decline. If surgically accessible, outcome following removal of a brain abscess can be excellent; aerobic and anaerobic bacterial culture should be performed in these cases. Subdural hematoma can occur following removal of a large intracranial mass. Growing skull fractures can occur in dogs but may not require specific surgical considerations.

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Brain Abscess: Management and Outcome Analysis of a Computed Tomography Era Experience with 973 Patients

Cited by 187 publications

References 31 publications

Neuro-Intensive Care of Patients with Acute CNS Infections

Neuro-Intensive Care of Patients with Acute CNS Infections

Increased occurrence of brain abscesses in cirrhotic patients: A population-based 3-year follow-up study

Surgical Treatment of a Chronic Brain Abscess and Growing Skull Fracture in a Dog

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