Brain abscess secondary to dental infection

Gold, Lionel

doi:10.1016/0030-4220(49)90002-x

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…A recent newspaper report described an incident involving a 12‐year‐old American child who reportedly died because of an infection from a dental abscess, associated with a molar tooth, that spread to the child’s brain (19). Although the focal infection theory was proposed in the 19th century (17) and there have since been several case reports in the literature corroborating this hypothesis (2, 3, 7, 8, 10, 13, 18), this incident drew vast attention and prompted a deluge of interest in the importance of dental health to general health. It also motivated a nationwide debate in the USA about access to regular dental care, particularly for children.…”

Section: Acute Focal Infections Of Dental Originmentioning

confidence: 99%

Aggressive and acute periodontal diseases

Albandar¹

2014

Periodontology 2000

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Inflammatory periodontal diseases are highly prevalent, although most of these diseases develop and progress slowly, often unnoticed by the affected individual. However, a subgroup of these diseases include aggressive and acute forms that have a relatively low prevalence but show a rapid-course, high rate of progression leading to severe destruction of the periodontal tissues, or cause systemic symptoms that often require urgent attention from healthcare providers. Aggressive periodontitis is an early-onset, destructive disease that shows a high rate of periodontal progression and distinctive clinical features. A contemporary case definition of this disease is presented. Population studies show that the disease is more prevalent in certain geographic regions and ethnic groups. Aggressive periodontitis is an infectious disease, and recent data show that in affected subjects the subgingival microbiota is composed of a mixed microbial infection, with a wide heterogeneity in the types and proportions of microorganisms recovered. Furthermore, there are significant differences in the microbiota of the disease among different geographic regions and ethnicities. There is also evidence that the Aggregatibacter actinomycetemycomitans-JP2 clone may play an important role in the development of the disease in certain populations. The host response plays an important role in the susceptibility to aggressive periodontitis, where the immune response may be complex and involve multiple mechanisms. Also, genetic factors seem to play an important role in the pathogenesis of this disease, but the mechanisms of increased susceptibility are complex and not yet fully understood. The available data suggest that aggressive periodontitis is caused by mutations either in a few major genes or in multiple small-effect genes, and there is also evidence of gene-gene and gene-environment interaction effects. Diagnostic methods for this disease, based on a specific microbiologic, immunologic or genetic profile, currently do not exist. Genetic markers have the potential to be implemented as screening tools to identify subjects at risk. This approach may significantly enhance treatment outcome through the early detection and treatment of affected subjects, as well as using future approaches based on gene therapy. At present, the treatment of this disease is directed toward elimination of the subgingival bacterial load and other local risk factors. Adjunctive use of appropriate systemic antibiotics is recommended and may contribute to a longer suppression of the microbial infection. Other aggressive forms of periodontal diseases occur in patients who are affected with certain systemic diseases, including the leukocyte adhesion deficiency syndrome, Papillon-Lefèvre syndrome, Chediak-Higashi syndrome and Down syndrome. Management of the periodontal component of these diseases is very challenging. Acute gingival and periodontal lesions include a group of disorders that range from nondestructive to destructive forms, and these lesions are usually assoc...

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Section: Acute Focal Infections Of Dental Originmentioning

confidence: 99%

Aggressive and acute periodontal diseases

Albandar¹

2014

Periodontology 2000

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“…However, if the disseminated microorganisms find favorable conditions, they may settle at a given site and after a certain time lag, start to multiply. Thus, in compromised patients, bacteremia may be a potential danger, leading to infective endocarditis, a brain abscess or other nonoral diseases (4,(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53).…”

Section: Oral Infectionmentioning

confidence: 99%

Brain abscesses caused by oral infection

Tronstad

Olsen

1999

Dental Traumatology

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Brain abscesses are rare but can be life-threatening infections. Recent progress in microbiological classification and identification has indicated that they are sometimes caused by oral infection and dental treatment. It has been postulated that oral microorganisms may enter the cranium by several pathways: 1) by direct extension, 2) by hematogenous spread, 3) by local lymphatics, and 4) indirectly, by extraoral odontogenic infection. In the direct extension, oral infections spread along the fascial planes. Hematogenous spreading occurs along the facial, angular, ophthalmic, or other veins which lack valves, through the cavernous sinus and into the cranium. Another hematogenous pathway is through the general circulation. Oral bacteria may cause systemic infections, e.g., endocarditis, and then indirectly initiate brain abscess. Microbiota, complications, and the prevention and management of odontogenic brain abscesses are also discussed in this review.

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Herderkrankungen aus mund-, kiefer- und gesichtschirurgischer Sicht

Keßler

HNO Praxis Heute

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Brain abscess secondary to dental infection

Cited by 10 publications

References 12 publications

Aggressive and acute periodontal diseases

Aggressive and acute periodontal diseases

Brain abscesses caused by oral infection

Herderkrankungen aus mund-, kiefer- und gesichtschirurgischer Sicht

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