Brain activation and heart rate during script-driven traumatic imagery in PTSD: Preliminary findings

Barkay, Gavriel; Freedman, Nanette; Lester, Hava; Louzoun, Yoram; Sapoznikov, Dan; Luckenbaugh, Dave; Shalev, Arieh Y.; Chisin, Roland; Bonne, Omer

doi:10.1016/j.pscychresns.2012.08.007

Cited by 23 publications

(13 citation statements)

References 35 publications

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“…Such a pattern has indeed been reported across a number of different paradigms including emotion-provoking pictures and film scenes, facial processing, gambling tasks, and traumatic script-driven imagery [Cohen et al, 2013;Etkin and Wager, 2007;Felmingham et al, 2008;Hopper et al, 2007b;Lanius et al, 2012Lanius et al, , 2015Mickleborough et al, 2011;Reiser et al, 2014;Shin et al, 2006;van Wingen et al, 2011]. Interestingly, a recent positron emission tomography study in PTSD found an increased correlation between HR and activation in orbitofrontal, precentral and occipital regions in response to traumatic scripts solely among individuals with PTSD [Barkay et al, 2012], suggesting that sensorimotor regions might regulate the stress response induced by traumatic scripts in PTSD. In comparison, the absence of HRV-CAN covariation at rest within the present sample demonstrates a lack of top-down CAN regulation of autonomic responses.…”

Section: Discussionmentioning

confidence: 71%

“…While higher HRV scores in healthy controls predicted increased functional connectivity within regions of the CAN (vmPFC to bilateral insula; left amygdala to the left PAG; PAG to right medial and superior PFC dorsal cingulate cortex, and left thalamus; for metaanalyses see also [Beissner et al, 2013;Thayer et al, 2012], measures of HRV within the PTSD group were unrelated with functional connectivity within CAN-related brain regions. Interestingly, a recent positron emission tomography study in PTSD found an increased correlation between HR and activation in orbitofrontal, precentral and occipital regions in response to traumatic scripts solely among individuals with PTSD [Barkay et al, 2012], suggesting that sensorimotor regions might regulate the stress response induced by traumatic scripts in PTSD. Such a pattern has indeed been reported across a number of different paradigms including emotion-provoking pictures and film scenes, facial processing, gambling tasks, and traumatic script-driven imagery [Cohen et al, 2013;Etkin and Wager, 2007;Felmingham et al, 2008;Hopper et al, 2007b;Lanius et al, 2012Lanius et al, , 2015Mickleborough et al, 2011;Reiser et al, 2014;Shin et al, 2006;van Wingen et al, 2011].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, given that only one related study links HR to cerebral blood flow during traumatic script exposure [Barkay et al, 2012], future studies using symptom provocation are expected to be useful in identifying potential differential functional connectivity patterns in relation to HRV in PTSD. Due to the cross-sectional design of the present study, these findings provide no indication of whether decreased HRV is caused by traumatic stress or represents a preexisting vulnerability factor.…”

Section: Discussionmentioning

confidence: 99%

“…We did not include traumaexposed individuals without PTSD in our analyses, as screened individuals matched for trauma severity met exclusion criteria for current or past psychiatric disorders. In addition, given that only one related study links HR to cerebral blood flow during traumatic script exposure [Barkay et al, 2012], future studies using symptom provocation are expected to be useful in identifying potential differential functional connectivity patterns in relation to HRV in PTSD. Here, comparing peripheral physiological and neuronal responses during resting state to those induced during symptom provocation will be necessary to gain insights into emotional regulatory capacity in response to stressors.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Thome

Densmore

Frewen

et al. 2016

Human Brain Mapping

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show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Thome

Densmore

Frewen

et al. 2016

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…It can alter the intensity of emotions such as anxiety (Cumming, Olphin, & Law, 2007;Nilsson, Lungh, & Viborg, 2012;Williams, Cumming, & Balanos, 2010;Williams & Cumming, 2012a). Imaging emotional content can also alter cardiovascular activity such as heart rate (Barkay et al, 2012;Cumming et al, 2007; McTeague, Lang, Laplante, & Bradley, 2011;Williams et al 2010). For example, imaging nervousness and elevations in heart rate associated with anticipation of competition can elicit feelings of anxiety and increase heart rate and cardiac output even when the competition is not immediately forthcoming (Cumming et al, 2007;Williams et al, 2010).…”

Section: Stressmentioning

confidence: 99%

Challenge and threat imagery manipulates heart rate and anxiety responses to stress

Williams

Zanten

Trotman

et al. 2017

International Journal of Psychophysiology

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This study investigated the influence of different types of mental imagery on heart rate and anxiety responses to a standard psychological stress task. Using a within-design, 25 females (M=23.24; SD=4.19) imaged three different scripts (challenge, threat, and neutral) to manipulate appraisal of a speech preparation task. Following each script, participants completed the task. Heart rate was recorded during a resting baseline prior to each imagery script and during each speech preparation task. Cognitive and somatic anxiety and self-confidence were assessed prior to the speech preparation trials, and immediately prior to each speech preparation following imagery. Following threat imagery, participants reported the speech preparation task to be significantly more stressful and threatening, and experienced lower levels of confidence and more negative interpretations of their anxiety symptoms compared with the challenge and neutral imagery conditions. Additionally, there was a significantly greater increase in heart rate following threat imagery compared with challenge and neutral imagery. Findings demonstrate that imagery can alter stress appraisal and the accompanying cardiovascular and psychological responses to standardized stress tasks. Imagery interventions, acknowledging the stressful nature of events, but emphasising feelings of efficacy and control are likely to lead to more adaptive coping.

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Psychophysiology in the Study of Psychological Trauma: Where Are We Now and Where Do We Need to Be?

Acheson

Geyer

Risbrough

2014

Current Topics in Behavioral Neurosciences

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Posttraumatic stress disorder (PTSD) is a major public health concern, which has been seeing increased recent attention partly due to the wars in Iraq and Afghanistan. Historically, research attempting to understand the etiology and treatment of PTSD has made frequent use of psychophysiological measures of arousal as they provide a number of advantages in providing objective, non-self-report outcomes that are closely related to proposed neurobiological mechanisms and provide opportunity for cross-species translation. Further, the ongoing shift in classification of psychiatric illness based on symptom clusters to specific biological, physiological, and behavioral constructs, as outlined in the US National Institute of Mental Health (NIMH) Research Domain Criteria project (RDoC), promises that psychophysiological research will continue to play a prominent role in research on trauma-related illnesses. This review focuses on the current state of the knowledge regarding psychophysiological measures and PTSD with a focus on physiological markers associated with current PTSD symptoms, as well as markers of constructs thought to be relevant to PTSD symptomatology (safety signal learning, fear extinction), and psychophysiological markers of risk for developing PTSD following trauma. Future directions and issues for the psychophysiological study of trauma including traumatic brain injury (TBI), treatment outcome studies, and new wearable physiological monitoring technologies are also discussed.

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Brain activation and heart rate during script-driven traumatic imagery in PTSD: Preliminary findings

Cited by 23 publications

References 35 publications

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Challenge and threat imagery manipulates heart rate and anxiety responses to stress

Psychophysiology in the Study of Psychological Trauma: Where Are We Now and Where Do We Need to Be?

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