Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia

Zhang, Liwen; Opmeer, Esther M.; Ruhé, Henricus G.; Alemán, André; Meer, Lisette van der

doi:10.1016/j.nicl.2015.04.010

Cited by 47 publications

(41 citation statements)

References 57 publications

(99 reference statements)

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“…In particular, abnormal morphology of these regions associated with aberrant self/other processing may be responsible for poor ToM performance. This is consistent with negative self‐referent information processing bias (Molz Adams, Shapero, Pendergast, Alloy, & Abramson, ), deficits in self‐referential processing (Zhao et al, ), and impaired integration of emotion and memory during other‐reflection (Zhang, Opmeer, Ruhe, Aleman, & van der Meer, ) previously reported in BD. This provides new insight into the neuroanatomical substrates of social cognitive deficits in BD (Bora et al, ) that have not been examined before.…”

Section: Discussionsupporting

confidence: 88%

Structural brain morphometry associated with theory of mind in bipolar disorder and schizophrenia

2019

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Schizophrenia (SZ) and bipolar I disorder (BD) share common functional and structural brain abnormalities, as well as various degrees of social cognitive deficits, suggesting shared brain mechanisms. This study examined the relationship between social cognitive skills and structural brain integrity in 60 cases with SZ, 65 cases with psychotic BD, and 61 healthy controls (HCs). All participants underwent structural MRI and completed The Awareness of Social Inference Test (TASIT). Associations between social cognitive performance on each task of the TASIT (Emotion Recognition, Theory of Mind [ToM], and Complex ToM) and indices of gray matter volume and cortical thickness were investigated within three separate groups comprising (a) all cases with a history of psychosis (independently of their diagnostic status), (b) each diagnostic category separately, and (c) an HC group. Cases with psychosis showed worse social cognitive performance compared to the HC group, and SZ cases performed worse than BD on all ToM tasks, but not the Emotion Recognition subtest. Poor ToM performance was associated with thinner anterior temporal lobe in the combined group of cases with psychosis, and with decreased volume of the left fusiform gyrus/cerebellum in the HC group. In the BD group alone, poor ToM performance was associated with similar pattern of thinner anterior temporal lobe, as well as with increased volume in the mid-and posterior cingulate cortex/ precuneus. However, there were no associations between brain morphometry and social cognition in the SZ group when considered alone.Taken together, ToM behavioral deficits were associated with thinner right anterior temporal lobe, a critical region from a larger affective ToM network among all cases with psychosis, but aberrant morphology of brain regions key for self-processing were specific to the BD group. These findings may have important implications for targeted interventions for the affective social brain network in BD.

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Section: Discussionsupporting

confidence: 88%

Structural brain morphometry associated with theory of mind in bipolar disorder and schizophrenia

2019

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“…Consistent with this, studies employing both structural 99 and functional [100][101][102][103][104][105] neuroimaging have implicated a number of areas and networks in the development and maintenance of insight.…”

Section: Abnormalities In Brain Function As a Root Of Poor Insightmentioning

confidence: 65%

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

et al. 2018

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Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that poor insight predicts poorer treatment adherence and therapeutic alliance, higher symptom severity and more impaired community function, while good insight predicts a higher frequency of depression and demoralization, especially when coupled with stigma and social disadvantage. This research also suggests that poor insight may arise in response to biological, experiential, neuropsychological, social-cognitive, metacognitive and socio-political factors. Studies of the effects of existing and developing treatments indicate that they may influence insight. In the context of earlier research and historical models, these findings support an integrative model of poor insight. This model suggests that insight requires the integration of information about changes in internal states, external circumstances, others' perspectives and life trajectory as well as the multifaceted consequences and causes of each of those changes. One implication is that treatments should, beyond providing education, seek to assist persons with schizophrenia to integrate the broad range of complex and potentially deeply painful experiences which are associated with mental illness into their own personally meaningful, coherent and adaptive picture.

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“…SZ > BD in DMPFC activation during retrieval, SZ > HC in DLPFC activation during retrievalMilanovic et al 66 201119/10/0/12PChronicMedicated1.5n-BackBlockSZ > HC = BD activation in the MPFC region of interest, but no group differences in the DLPFC region of interestCostrafreda et al 69 201140/32/0/32ChronicMedicated1.5Phonological letter fluencyBlockSZ > BD > HC activation in anterior cingulate, middle frontal gyrus, and putamen. SZ > BD = HC superior, middle, and inferior frontal gyrus; SZ = BD > HC in precuneus, posterior cingulate, and angular gyrusMorris et al 72 201215/12/0/13ChronicMedicated3Emotionally salient memoryBlockBD > SZ > HC in emotion downregulation in the prefrontal cortex; BD = SZ > HC in emotion upregulation in prefrontal cortexPalaniyappan et al 134 201334/34/0/20PChronicMedicated3n-BackBlockHC > SZ in degree centrality in frontal lobe, STG and insula, HC > BD in degree centrality in insula, SZ > HC in hippocampus, thalamus, and fusiform gyrus, BD > HC hippocampus, thalamus, and caudateBrandt et al 65 2014100/86/14/100P/NPChronicMedicated1.5n-BackBlockSZ > BD > HC in activation in the dorsolateral and ventrolateral PFC, premotor cortex and parietal cortex; HC > BD > SZ in inferior frontal gyrus, inferior parietal cortex, STG, and precuneusWu et al 67 201429/36/0/20ChronicMedicated3n-BackBlockSZ > BD > HC in hyperactivity in the PCC and MPFCZhang et al 135 201521/17/0/17PChronicMedicated3self-reflection taskBlockHC > BD in PCC precuneus activation during other vs. self-contrastHagele et al 73 201554/44/0/13ChronicMedicated1.5Monetary incentive delaySZ showed less ventral striatal activation compared to HC = BD during reward anticipation. No group differences in loss anticipation

HC healthy control, BD bipo...

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Section: Resultsmentioning

confidence: 99%

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

et al. 2017

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Since Emil Kraepelin's conceptualization of endogenous psychoses as dementia praecox and manic depression, the separation between primary psychotic disorders and primary affective disorders has been much debated. We conducted a systematic review of case-control studies contrasting magnetic resonance imaging studies in schizophrenia and bipolar disorder. A literature search in PubMed of studies published between January 2005 and December 2016 was conducted, and 50 structural, 29 functional, 7 magnetic resonance spectroscopy, and 8 combined imaging and genetic studies were deemed eligible for systematic review. Structural neuroimaging studies suggest white matter integrity deficits that are consistent across the illnesses, while gray matter reductions appear more widespread in schizophrenia compared to bipolar disorder. Spectroscopy studies in cortical gray matter report evidence of decreased neuronal integrity in both disorders. Functional neuroimaging studies typically report similar functional architecture of brain networks in healthy controls and patients across the psychosis spectrum, but find differential extent of alterations in task related activation and resting state connectivity between illnesses. The very limited imaging-genetic literature suggests a relationship between psychosis risk genes and brain structure, and possible gene by diagnosis interaction effects on functional imaging markers. While the existing literature suggests some shared and some distinct neural markers in schizophrenia and bipolar disorder, it will be imperative to conduct large, well designed, multi-modal neuroimaging studies in medication-naïve first episode patients that will be followed longitudinally over the course of their illness in an effort to advance our understanding of disease mechanisms.

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Brain activation during self- and other-reflection in bipolar disorder with a history of psychosis: Comparison to schizophrenia

Cited by 47 publications

References 57 publications

Structural brain morphometry associated with theory of mind in bipolar disorder and schizophrenia

Structural brain morphometry associated with theory of mind in bipolar disorder and schizophrenia

Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

Brain structure, function, and neurochemistry in schizophrenia and bipolar disorder—a systematic review of the magnetic resonance neuroimaging literature

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