Brain aging and Alzheimer’s disease, a perspective from non-human primates

Abstract

Brain aging is a biological process that comprehends degenerative, adaptive, and regenerative brain changes that elapse through maturity until the elderly. Yet, brain aging is often considered the transformation of the brain in old age. Brain aging encompasses modifications of molecules, neurons and glial cells, neural networks, vasculature, and ultimately, brain function, behavior, and cognition. Characteristics of senile plaques, cerebral amyloid angiopathy, and neurofibrillary tangles in human brain agingSenile plaques (SPs) and neurofibrillary tangles (NFTs) are principal neuropathological alterations of human brain aging and the hallmarks of Alzheimer's disease (AD). For this reason, SPs and NFTs are named Alzheimer's disease neuropathological change (ADNC) [1][2][3][4][5][6][7].