Brain anatomy of persistent violent offenders: More rather than less

Tiihonen, Jari; Rossi, Roberta; Laakso, Mikko P.; Hodgins, Sheilagh; Testa, Cristina; Pérez, Jorge; Repo-Tiihonen, Eila; Vaurio, Olli; Soininen, Hilkka; Aronen, Hannu J.; Könönen, Mervi; Thompson, Paul M.; Frisoni, Giovanni B.

doi:10.1016/j.pscychresns.2007.08.012

Cited by 154 publications

(170 citation statements)

References 41 publications

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“…Second, difficulties in control of voluntary behaviour should be associated with abnormalities or deficits in insular function. AIC volume has been associated with psychopathy (de Oliveira-Souza et al 2008;Tiihonen et al 2008), and with conduct disorder (Sterzer et al 2007). However, a further recent study on pre-teen boys with conduct disorder found no structural difference in AIC relative to a control group (De Brito et al 2009).…”

Section: The Role Of the Aic In Intentional Actionmentioning

confidence: 99%

The hidden side of intentional action: the role of the anterior insular cortex

Braß

Haggard

2010

Brain Struct Funct

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Cognitive neuroscience research has begun to reveal the functional neuroanatomy of intentional action. This research has primarily pointed to the role of the medial frontal cortex for the voluntary control of behaviour. However, a closer inspection of the literature reveals that the anterior insular cortex (AIC) is also routinely activated in tasks that involve different aspects of intentional action. In the present article, we outline studies that have found AIC activation in various intentional action paradigms. Based on these findings, we discuss two hypotheses about the AIC's contribution to voluntary control. One hypothesis states that AIC is involved in forming intentions, by providing information about the internal states of the system. The alternative view suggests that AIC evaluates the outcomes of intentional action decisions that have been previously formed elsewhere. The limited evidence so far favours the evaluative hypothesis. AIC may provide interoceptive signals that play an essential role in evaluating the consequences of intentional action. AIC is therefore a key structure for the adaptive, affective training of the individual will, on which human society depends.

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Section: The Role Of the Aic In Intentional Actionmentioning

confidence: 99%

The hidden side of intentional action: the role of the anterior insular cortex

Braß

Haggard

2010

Brain Struct Funct

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“…As the PFC is a key component of the neural circuit involved in fear conditioning and stress responsivity, the fi ndings suggest prefrontal defi cits may account for the reported diffi culties in fear conditioning and autonomic responsiveness in anti-social populations. In more recent quantitative voxel-based morphology (VBM) studies in people with ASPD, Tiihonen et al (2008) reported that people with ASPD who had been violent had reduced GM volume in the OFC, frontopolar cortex (FPC) and superior temporal gyrus (STG), but increased white matter (WM) volume in posterior brain areas, all compared healthy controls. This may refl ect atypical neurodevelopmental processes in people with ASPD.…”

Section: Structural Imaging Studies In Impulsive-aggressive Pdsmentioning

confidence: 99%

What imaging tells us about violence in anti‐social men

Dolan

2010

Criminal Behav Ment Health

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This paper provides an overview of imaging studies in samples of men with personality disorder (PD) who have been violent. Mention is also made of the work of two groups that have looked at the neural correlates of violence across diagnostic categories, including schizophrenia and anti-social PD given their relevance in the field. The paper focuses on the notion that aggressive behaviour can be conceptualised in terms of at least two types, reactive and pro-active, and that few studies separate them. The neuro-anatomical basis of aggression and associated neurobehavioural theories are discussed in relation to clinical disorders (mainly anti-social personality pathology) associated with these different types of aggressive behaviour. Structural (computed tomography, magnetic resonance imaging) and functional (positron emission tomography, fMRI, single-photon emission tomography) studies with violent people variously characterised as anti-social or having psychopathy will be critically reviewed.

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“…This approach fits with a current impetus in the field, a recommendation by Zald and Rauch (2006), to focus more attention on the functionally heterogeneous orbitofrontal cortex (OFC) and relevant emotional processes, as this is the most under-studied region of the PFC. Indeed, several investigations highlight the importance of the association of the OFC to emotional behaviors across different types of psychiatric patients (Hoptman et al 2005;Rusch et al 2008;Tiihonen et al 2008). A VBM approach has demonstrated persistently violent offenders with antisocial personality disorder and substance dependence had less gray matter in frontopolar and orbital frontal cortices than healthy men (Tiihonen et al 2008).…”

mentioning

confidence: 99%

“…Indeed, several investigations highlight the importance of the association of the OFC to emotional behaviors across different types of psychiatric patients (Hoptman et al 2005;Rusch et al 2008;Tiihonen et al 2008). A VBM approach has demonstrated persistently violent offenders with antisocial personality disorder and substance dependence had less gray matter in frontopolar and orbital frontal cortices than healthy men (Tiihonen et al 2008). Rusch and colleagues (Rusch et al 2008) postulated, on the basis of their finding in schizophrenia of a positive correlation of suicide history and self-aggression and bilateral inferior frontal white matter, that such alterations might be structural correlates of dysfunctional impulse control.…”

mentioning

confidence: 99%

A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression

Emerton

Jerram

Deckersbach

et al. 2009

Brain Imaging and Behavior

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The assumption that voxel-based morphometry (VBM) offers an automated substitution for manually-traced volumetry was subjected to empirical evaluation. Data available from a previous volumetry study (Gansler et al. Psychiatry Research: Neuroimaging 171:145–154, 2009) provided the basis for the current study, which assessed for convergence between the methods. Optimized modulated VBM was used to preprocess images (N = 40). Gray matter volume and self-reported aggression associations were tested. Results indicate convergence, as both methods revealed significant negative associations of the left orbitofrontal cortex (OFC) and aggression. VBM detected an additional positive left OFC result not revealed with volumetry, suggesting that VBM may allow greater within-region localization than volumetry. However, the methods differentially deal with error rates and power demands and as such are better conceptualized as complementary than interchangeable

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Brain anatomy of persistent violent offenders: More rather than less

Cited by 154 publications

References 41 publications

The hidden side of intentional action: the role of the anterior insular cortex

The hidden side of intentional action: the role of the anterior insular cortex

What imaging tells us about violence in anti‐social men

A Comparison of Voxel-Based Morphometry and Volumetry Methods in the Context of the Neural Basis of Aggression

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