Brain and Cardiovascular Diseases: Molecular Aspects

Szczepañska‐Sadowska, Ewa

doi:10.1002/9781118395318.ch27

Cited by 1 publication

(2 citation statements)

References 165 publications

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“…Multiple studies indicate that post-infarct heart failure is associated with significant changes in the activity of classical and non-classical transmitting systems [94]. Significant stimulation of glutamatergic neurons and NMDA-and non-NMDA receptors in the RVLM was found by Wang et al [95].…”

Section: Long Term-cardiovascular and Neuroendocrine Disorders After The Myocardial Infarctionmentioning

confidence: 97%

“…It is noteworthy that several neurochemical pathways, which are affected during stress or depression, manifest also altered activity in heart failure. This refers to the GABA-ergic, noradrenergic and serotonergic pathways of PVN and RVLM [94,118,119]. For instance mice lacking 5HT1A receptors manifested more anxiety and were more vulnerable to sudden cardiac death [118].…”

Section: Altered Neurochemical Control Of Blood Pressure During Stressmentioning

confidence: 99%

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Significance of Neuropeptides for Coexistence of Disturbances in Central Cardiovascular Control in Heart Failure, Stress and Depression

Szczepañska‐Sadowska¹,

Cudnoch‐Jędrzejewska²,

Wsol³

et al. 2014

J Clin Exp Cardiolog

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There are solid grounds for the recognition of the involvement of multiple neuronal/neurotransmitter networks in the regulation of the cardiovascular system. Clinical and preclinical studies provide evidence that heart failure is associated with significant changes in the central control of some of these systems. In addition, it has been shown that some of the brain's neurochemical pathways, which are involved in the central control of blood pressure, play a role in the regulation of emotions and cognitive functions. Stress and depression are regarded as potential challenges for the cardiovascular system, causing inappropriate regulation of cardiovascular parameters and worsening the prognosis of heart failure. There is also evidence that heart failure increases sensitivity to stress and depression. Recently, knowledge of the neurochemical background of comorbidity of stress, depression and heart failure has increased markedly. Our studies and those of other authors provided evidence for significant role of the improper function of neuropeptides, and in particular of the angiotensinergic, vasopressinergic and oxytocinergic systems in the exaggerated responsiveness of the cardiovascular system to stress in heart failure and depression. Current evidence indicates that the inappropriate regulation of the release of these neuropeptides and/or expression of their receptors play a particularly important role in long-term changes of central cardiovascular control during postinfarct heart failure.

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Section: Long Term-cardiovascular and Neuroendocrine Disorders After The Myocardial Infarctionmentioning

confidence: 97%

Section: Altered Neurochemical Control Of Blood Pressure During Stressmentioning

confidence: 99%

Significance of Neuropeptides for Coexistence of Disturbances in Central Cardiovascular Control in Heart Failure, Stress and Depression

Szczepañska‐Sadowska¹,

Cudnoch‐Jędrzejewska²,

Wsol³

et al. 2014

J Clin Exp Cardiolog

View full text Add to dashboard Cite

show abstract

Brain and Cardiovascular Diseases: Molecular Aspects

Cited by 1 publication

References 165 publications

Significance of Neuropeptides for Coexistence of Disturbances in Central Cardiovascular Control in Heart Failure, Stress and Depression

Significance of Neuropeptides for Coexistence of Disturbances in Central Cardiovascular Control in Heart Failure, Stress and Depression

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