BRAIN AND EYE AS POTENTIAL TARGETS FOR IONIZING RADIATION IMPACT. Part І. THE CONSEQUENCES OF IRRADIATION OF THE PARTICIPANTS OF THE LIQUIDATION OF THE CHORNOBYL ACCIDENT

Loganovsky, K.; Fedirko, P.; Kuts, K.; Marazziti, Donatella; Antypchuk, K.; Perchuk, I.; Babenko, T.; Loganovska, T K; Kolosynska, O.; Kreinis, G.; Gresko, M.; Masiuk, Sergii; Zdorenko, L.; Zdanevich, N.; Garkava, N.; Dorichevska, R.; Vasilenko, Z.; Kravchenko, Victor; Drosdova, N.; Yefimova, Yu.

doi:10.33145/2304-8336-2020-25-90-129

Cited by 7 publications

(1 citation statement)

References 128 publications

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“…The brain is very sensitive to radiation exposure. Radiation can affect the central nervous system, leading to mental retardation, behavioral changes, cognitive impairment, and neoplastic diseases [22,23]. Although it is well known that high dose rate radiation causes damage to the brain, skin and eye [24][25][26][27], the effect of low dose radiation on the hu-man brain is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Huang¹,

Zhang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor-related signal transduction pathways to produce neuroprotective effects.

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Section: Introductionmentioning

confidence: 99%

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Huang¹,

Zhang²,

Chen³

et al. 2023

Front. Biosci. (Landmark Ed)

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Real time eye dose reduction in fluoroscopy with auditory and visual feedback dosimeter through swine model experiments

Khan,

2024

Sci Rep

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Brain and Eye as Potential Targets for Ionizing Radiation Impact. Part Iii - Features Morphometric Retinal Parameters, Amplitude and Latency Components of Visual Evoked Potential in Radiation Exposed in Utero

Babenko¹,

Loganovsky²,

Loganovska³

et al. 2021

Probl Radiac Med Radiobiol

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One of the current problems of modern radiobiology is determine the characteristics of the manifestation of radiation-induced effects not only at different dose loads, but also at different stages of development of the organism. In previous reports, we have summarized available evidence that at certain ages there is a comparative acceleration of radiation-induced pathological changes in the eye and brain, and the study and assessment of the risk of possible ophthalmic and neurological pathology in remote periods after contamination of radioactive areas. Data of irradiated in utero individuals are possible on the basis of observation of the state of the visual analyzer in persons who underwent intrauterine irradiation in 1986. Therefore, a parallel study of retinal morphometric parameters, amplitude and latency of components of evoked visual potentials in irradiated in utero individuals was performed. Objective: to evaluate the retinal morphometric parameters, amplitude and latency components of the evoked visual potentials in intrauterine irradiated persons. Materials and methods. The results of surveys of 16 people irradiated in utero in the aftermath of the Chornobyl disaster were used; the comparison group were residents of Kyiv of the corresponding age (25 people). Optical coherence tomography was performed on a Cirrus HD-OCT, Macular Cube 512x128 study technique was used. At the same time, the study of visual evoked potentials on the inverted pattern was performed, and occipital leads were analyzed. Visual evoked potentials were recorded on a reversible chess pattern (VEP) – an electrophysiological test, which is a visual response to a sharp change in image contrast when presenting a reversible image of a chessboard. Results. In those irradiated in utero at the age of 22–25 years, there was a probable increase in retinal thickness in the fovea, there was a tendency to increase the thickness of the retina in the areas around the fovea. When recording visual evoked potentials on a reversible chess pattern in this group, there was a tendency to decrease the amplitudes of components (N75, P100, N145, P200) in the right and left parieto-occipital areas and asymmetric changes in latency of these components. Conclusions. Early changes of fovea recorded in OCT and decreasing amplitudes of components of visual evoked potentials on the reversible chess pattern at the age of 22–25 years may indicate a risk of development in patients irradiated in utero, early age-related macular degeneration, as well as increased risk and increased risk structures of the visual analyzer. Key words: induced visual potentials, optical coherence tomography, retina, agerelated macular degeneration, ion izing radiation, dose.

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BRAIN AND EYE AS POTENTIAL TARGETS FOR IONIZING RADIATION IMPACT. Part І. THE CONSEQUENCES OF IRRADIATION OF THE PARTICIPANTS OF THE LIQUIDATION OF THE CHORNOBYL ACCIDENT

Cited by 7 publications

References 128 publications

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure

Real time eye dose reduction in fluoroscopy with auditory and visual feedback dosimeter through swine model experiments

Brain and Eye as Potential Targets for Ionizing Radiation Impact. Part Iii - Features Morphometric Retinal Parameters, Amplitude and Latency Components of Visual Evoked Potential in Radiation Exposed in Utero

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