Brain asymmetry differences between Chinese and Caucasian populations: a surface-based morphometric comparison study

Lou, Yunxia; Zhao, Lu; Yu, Shui; Sun, Bo; Hou, Zhen; Zhang, Zhonghe; Tang, Yuchun; Liu, Shuwei

doi:10.1007/s11682-019-00184-7

Cited by 18 publications

(28 citation statements)

References 67 publications

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“…Several limitations should be mentioned. First, our delineation of population-level asymmetry used a single analysis software, and it is unclear to what extent differences in pipelines account for mixed results 8,9,[11][12][13][14][15][16][17][18][19][20][21] , though several studies suggest our results reproduce across analysis systems 12,13,21,25 . Second, while GAMMs are considered an optimal modelling technique for longitudinal lifespan data and are robust to non-normal age distributions 73 , relative underrepresentation of the mid-adulthood age-range may drive trajectory inflection points around this age 11 , suggesting caution is warranted regarding interpreting mid-life inflection points as reflecting real change.…”

Section: Discussionmentioning

confidence: 97%

“…However, structural asymmetry is also a ubiquitous aspect of brain organization 8,9 . For instance, cortical thickness (CT) and surface area (SA) are known to exhibit distinct asymmetry patterns 8,10 , but these have been reported inconsistently 8,9,[11][12][13][14][15][16][17][18][19][20][21] . Yet disrupted cortical asymmetry is a confirmed feature of neurodevelopmental disorders 22 , aging 11 , and Alzheimer's disease 11,23,24 .…”

Section: Introductionmentioning

confidence: 99%

“…Although several studies have mapped cortical asymmetry 8,9,[11][12][13][14][15][16][17][18][19][20][21]25 , conflicting results may be partly due to the use of brain atlases with varying resolutions of analysis, especially if cortical asymmetry conforms poorly to the predefined anatomical boundaries 26,27 . Still, even amongst studies adopting an atlas-free approach, conflicting results abound [14][15][16][17][18][19] . For example, for CT asymmetry, medial prefrontal cortex (mPFC) has been reported to show both extensive rightward 15,17,18 and leftward [11][12][13]21 lateralization.…”

Section: Introductionmentioning

confidence: 99%

“…Still, even amongst studies adopting an atlas-free approach, conflicting results abound [13][14][15][16][17][18] . For example, for CT asymmetry, medial prefrontal cortex (mPFC) has been reported to show both extensive rightward 14,16,17 and leftward [10][11][12]20 lateralization. Beyond regional inconsistencies, a recent meta-analysis confirmed the cortex is globally organized in a characteristic pattern of CT asymmetry, wherein anterior and posterior regions are thicker in the left and right hemisphere, respectively 7 .…”

Section: Introductionmentioning

confidence: 99%

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Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

Roe

Vidal-Piñeiro

Amlien

et al. 2021

Preprint

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Cortical asymmetry is a ubiquitous feature of brain organization that is altered in neurodevelopmental disorders and aging. Achieving consensus on cortical asymmetries in humans is necessary to uncover the genetic-developmental mechanisms that shape them and factors moderating cortical lateralization. Here, we delineate population-level asymmetry in cortical thickness and surface area vertex-wise in 7 datasets and chart asymmetry trajectories across life (4-89 years; observations = 3937; 70% longitudinal). We reveal asymmetry interrelationships, heritability, and test associations in UK Biobank (N=∼37,500). Cortical asymmetry was robust across datasets. Whereas areal asymmetry is predominantly stable across life, thickness asymmetry grows in development and declines in aging. Areal asymmetry correlates in specific regions, whereas thickness asymmetry is globally interrelated across cortex and suggests high directional variability in global thickness lateralization. Areal asymmetry is moderately heritable (max h2SNP ∼19%), and phenotypic correlations are reflected by high genetic correlations, whereas heritability of thickness asymmetry is low. Finally, we detected an asymmetry association with cognition and confirm recently-reported handedness links. Results suggest areal asymmetry is developmentally stable and arises in early life, whereas developmental changes in thickness asymmetry may lead to directional variability of global thickness lateralization. Our results bear enough reproducibility to serve as a standard for future brain asymmetry studies.SignificanceCortical asymmetry is reduced in neurodevelopmental disorders, yet we lack knowledge of how cortical asymmetry development proceeds across life in health. We provide a definitive reference for asymmetry in the cerebral cortex. We find areal asymmetry is stable from childhood to old age, and specific areal asymmetries are formed under common genetic-developmental influence. In contrast, thickness asymmetry shows developmental growth, and is globally interrelated in a pattern suggesting highly left-lateralized individuals tend towards left-lateralization also in right-asymmetric regions (and vice versa). Heritability mapping also supported a prenatal-postnatal developmental dichotomy for areal and thickness asymmetry, and we find reduced asymmetry in the most lateralized brain region associates with reduced cognition. Our results provide novel insights into normal brain organization and development.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

Roe

Vidal-Piñeiro

Amlien

et al. 2021

Preprint

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“…The current research about Broca's area mainly focuses on the study of Occidental populations, but differences in genetics, culture and environmental exposures may give rise to differences in brain structure and function between the Oriental and Occidental populations (Lou et al 2019;Han and Ma 2014). According to SBM analysis, compared to Westerners, the Chinese population had smaller structural measures in the frontal and parietal regions (Tang et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Morphology and Hemispheric and Gender difference of the Anterior Ascending Ramus and the Horizontal Ascending Ramus of the Lateral Sulcus

Wang

liu

et al. 2021

Preprint

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Broca’s area is composed of the pars opercularis (PO) and the pars triangularis (PTR) of the inferior frontal gyrus，which was separated by the anterior ascending ramus of lateral sulcus (aals) and the horizontal ascending ramus of the lateral sulcus (hals). The morphometry of these two sulci maybe have potential effects on the various functions of Broca’s area. To explore the morphology variation, hemispheric and gender difference of these two sulci, so as to enable better understanding of their patterns and the functions of the Broca’s area. BrainVISA was used to reconstruct and parameterize these two sulci with 3D MR images of 90 healthy right-handed subjects. The 3D anatomic morphology of these two sulci was presented using 4 sulcal parameters, including average depth (AD), average width (AW), top length (TL) and bottom length (BL). The aals could be identified in 98.89% of the hemispheres, while the hals could be identified in 98.33%. The morphological patterns of these two sulci were categorized into four main types. There were no statistically significant interhemispheric and gender differences in the frequency of the morphological patterns. There was statistically significant interhemispheric difference in BL of the aals and AW of the hals. Significant gender differences were found in the bilateral AD of the aals and the BL and TL of the hals in right hemisphere. Our results will not only provide structural basis for the functional studies that related to Broca’s area, but also be helpful for the precise positioning of special structures in neurosurgery.

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Applying Transemics to Development, Culture, Causality, and Unifying Psychology

Young

2021

Causality and Neo-Stages in Development

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Brain asymmetry differences between Chinese and Caucasian populations: a surface-based morphometric comparison study

Cited by 18 publications

References 67 publications

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

Morphology and Hemispheric and Gender difference of the Anterior Ascending Ramus and the Horizontal Ascending Ramus of the Lateral Sulcus

Applying Transemics to Development, Culture, Causality, and Unifying Psychology

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