Brain Atrophy in Relapsing Optic Neuritis Is Associated With Crion Phenotype

Ln, Cantó; Sc, Boscá; Ca, Vicente; Gil-Perontín, S; Pérez‐Miralles, Francisco; Jc, Villalba; Lc, Nuñez; B, Casanova Estruch

doi:10.3389/fneur.2019.01157

Cited by 7 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies of brain volume in MOGAD are also scarce and limited by cross-sectional design. [15][16][17][18][19] No study to date has investigated the trajectory of brain growth in children with MOGAD.…”

Section: Discussionmentioning

confidence: 99%

Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination

et al. 2023

View full text Add to dashboard Cite

Background and Objectives:Pediatric acquired demyelination of the central nervous system associated with antibodies directed against myelin oligodendrocyte glycoprotein (MOG-antibody associated disease, MOGAD) occurs as a monophasic or relapsing disease and with variable but often extensive T2 lesions in the brain. The impact of MOGAD on brain growth during maturation is unknown. We quantified the effect of pediatric MOGAD on brain growth trajectories and compared this to the growth trajectories of age- and sex-matched healthy children as well as children with multiple sclerosis (MS, a chronic relapsing disease known to negatively affect brain growth) and monophasic seronegative demyelination.Methods:We included children enrolled at incident attack in the prospective longitudinal Canadian Pediatric Demyelinating Disease Study who were recruited at the three largest enrollment sites, underwent research brain MRI scans, and were tested for serum MOG-IgG antibodies. Children seropositive for MOG-IgG were diagnosed with MOGAD. MS was diagnosed per the 2017 McDonald criteria. Monophasic seronegative demyelination was confirmed in children with no clinical or MRI evidence of recurrent demyelination, and negative for MOG-IgG and aquaporin-4-IgG. Whole and regional brain volume was computed through symmetric non-linear registration to templates. We computed age- and sex-normalized z-scores for brain volume using a normative dataset of 813 brain MRI scans obtained from typically-developing children, and used mixed-effect models to assess potential deviation from brain growth trajectories.Results:We assessed brain volumes of 46 children with MOGAD, 26 with MS, and 51 with monophasic seronegative demyelinating syndrome. Children with MOGAD exhibited delayed (p<0.001) age- and sex-expected growth of thalamus, caudate and globus pallidus, normalized for the whole brain volume. Divergence from expected growth was particularly pronounced in the first year post-onset, and was detected even in children with monophasic MOGAD. Thalamic volume abnormalities were less pronounced in children with MOGAD compared to children with MS.Interpretation/discussion:The onset of MOGAD during childhood adversely affects the expected trajectory of growth of deep gray matter structures, with accelerated changes in the months following an acute attack. Further studies are required to better determine the relative impact of monophasic versus relapsing MOGAD, and whether relapsing MOGAD with attacks isolated to the optic nerves or spinal cord impacts brain volume over time.

show abstract

Section: Discussionmentioning

confidence: 99%

Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The optic nerve leads to signal transmission barriers and affects vision under certain circumstances [2,3], and can cause other complications related to brain activity [4]. For example, autistic patients with chronic ON exhibit nerve atrophy [5] and impairments in vision and cerebellar function [6] that suggest damage to specific brain areas. Recently, it was discovered that myelin oligodendrocyte glycoprotein (MOG) antibody was positive in the serum of AQP-4 antibody-negative ON patients.…”

Section: Introductionmentioning

confidence: 99%

Abnormal fractional amplitude of low-frequency fluctuations in MOG-lgG optic neuritis patients: a resting-state functional MRI study

Yang¹,

Xu²,

Li³

et al. 2022

J. Integr. Neurosci.

View full text Add to dashboard Cite

Optic neuritis (ON) is a general term for inflammation of any part of the optic nerve resulting from demyelination or infection. The number of patients with MOG-lgG antibody-related optic neuritis is increasing recently. Our study uses the fractional amplitude of lowfrequency fluctuation (fALFF) method to compare the activity of specific brain regions in MOG-lgG ON patients and healthy controls (HCs). We selected a total of 21 MOG-lgG ON patients and 21 HCs were included in the study. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI). The independent-samples t-test was used to compare demographic data and average fALFF values between groups. The specificity and sensitivity of fALFF values for distinguishing between MOG-lgG ON patients and HCs were evaluated by receiver operating characteristic (ROC) curve analysis. Pearson's correlation analysis was used to analyze the relationship between fALFF values and clinical characteristics in MOG-lgG ON patients. Our results showed that fALFF values of the right cerebellum and left middle cingulum were lower whereas those of bilateral inferior temporal lobes, right gyrus rectus, and the left superior and right middle frontal lobes of MOG-lgG ON patients were higher than those of HCs (P < 0.05). The average fALFF value of the left superior frontal lobe in MOG-lgG ON patients was positively correlated with Hospital Anxiety and Depression Scale score (HADS) (r = 0.6004; P < 0.05) and duration of MOG-lgG ON (r = 6487; P < 0.05). Thus, patients with MOG-lgG ON have abnormal activity in the brain regions related to vision. Changes in fALFF value can reflect functional sequelae of MOG-lgG ON, including abnormal anxiety or depressive emotional changes.

show abstract

“…In addition to demyelination, ON patients have abnormal activity in many brain regions [3]. For example, brain atrophy was observed in patients with chronic recurrent solitary ON [4], along with Wallerian degeneration in the optic tract, cerebellum, thalamus, posterior cingulate, and other brain areas [5], indicating that specific brain areas are affected in ON. Given that the visual loss caused by ON can negatively affect the quality of life of patients, it is important to clarify the pathogenesis and associated changes in the brain.…”

Section: Introductionmentioning

confidence: 99%

Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study

Song

Zhu

et al. 2021

Disease Markers

View full text Add to dashboard Cite

Aim. This study investigated changes in small-world topology and brain functional connectivity in patients with optic neuritis (ON) by resting-state functional magnetic resonance imaging (rs-fMRI) and based on graph theory. Methods. A total of 21 patients with ON (8 males and 13 females) and 21 matched healthy control subjects (8 males and 13 females) were enrolled and underwent rs-fMRI. Data were preprocessed and the brain was divided into 116 regions of interest. Small-world network parameters and area under the integral curve (AUC) were calculated from pairwise brain interval correlation coefficients. Differences in brain network parameter AUCs between the 2 groups were evaluated with the independent sample t -test, and changes in brain connection strength between ON patients and control subjects were assessed by network-based statistical analysis. Results. In the sparsity range from 0.08 to 0.48, both groups exhibited small-world attributes. Compared to the control group, global network efficiency, normalized clustering coefficient, and small-world value were higher whereas the clustering coefficient value was lower in ON patients. There were no differences in characteristic path length, local network efficiency, and normalized characteristic path length between groups. In addition, ON patients had lower brain functional connectivity strength among the rolandic operculum, medial superior frontal gyrus, insula, median cingulate and paracingulate gyri, amygdala, superior parietal gyrus, inferior parietal gyrus, supramarginal gyrus, angular gyrus, lenticular nucleus, pallidum, superior temporal gyrus, and cerebellum compared to the control group ( P < 0.05 ). Conclusion. Patients with ON show typical “small world” topology that differed from that detected in HC brain networks. The brain network in ON has a small-world attribute but shows reduced and abnormal connectivity compared to normal subjects and likely causes symptoms of cognitive impairment.

show abstract

Brain Atrophy in Relapsing Optic Neuritis Is Associated With Crion Phenotype

Cited by 7 publications

References 37 publications

Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination

Deviation From Normative Whole Brain and Deep Gray Matter Growth in Children With MOGAD, MS, and Monophasic Seronegative Demyelination

Abnormal fractional amplitude of low-frequency fluctuations in MOG-lgG optic neuritis patients: a resting-state functional MRI study

Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study

Contact Info

Product

Resources

About