Purpose: The objective of this research is to investigate how brain-based learning (BBL) has been adopted in Indonesia and its influence on the overall learning experience. Design/Approach/Methods: This research employs a systematic literature review methodology, adhering to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and utilizing the Scopus and Google Scholar databases. Out of 2198 articles initially identified, only 101 met the predetermined criteria, leading to subsequent content analysis. Findings: The findings indicate: (1) an upward trend in research activity from 2013 to 2019 followed by a decline from 2020 to 2024; (2) predominance of quasi-experimental approaches; (3) the relevance of BBL across various educational levels; (4) a focus on mathematics and science in research endeavors; and (5) the positive impact of BBL on diverse learning facets. Originality/Value: This study provides valuable insights for stakeholders keen on advancing BBL research, exploring novel avenues across different methodologies, educational domains, and expertise areas. Such endeavors foster innovation in BBL research, underscoring its beneficial role in enhancing the educational landscape in Indonesia.