Brain Biomarkers: Follow-Up of RNA Expression Discovery Approach: CSF Assays for Neurogranin, SNAP-25, and VILIP-1

Herries, Elizabeth M.; Brada, Nancy; Sutphen, Courtney L.; Ladenson, Jack H.

doi:10.1007/978-1-0716-1319-1_12

Neuromethods

2021

DOI: 10.1007/978-1-0716-1319-1_12

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Brain Biomarkers: Follow-Up of RNA Expression Discovery Approach: CSF Assays for Neurogranin, SNAP-25, and VILIP-1

Elizabeth M. Herries¹,

Nancy Brada²,

Courtney L. Sutphen³

et al.

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2024

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CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

Delvenne,

Gobom,

Schindler

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWe aimed to unravel the underlying pathophysiology of the neurodegeneration (N) markers neurogranin (Ng), neurofilament light (NfL), and hippocampal volume (HCV), in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics.METHODSIndividuals without dementia were classified as A+ (CSF amyloid beta [Aβ]42), T+ (CSF phosphorylated tau181), and N+ or N− based on Ng, NfL, or HCV separately. CSF proteomics were generated and compared between groups using analysis of covariance.RESULTSOnly a few individuals were A+T+Ng−. A+T+Ng+ and A+T+NfL+ showed different proteomic profiles compared to A+T+Ng− and A+T+NfL−, respectively. Both Ng+ and NfL+ were associated with neuroplasticity, though in opposite directions. Compared to A+T+HCV−, A+T+HCV+ showed few proteomic changes, associated with oxidative stress.DISCUSSIONDifferent N markers are associated with distinct neurodegenerative processes and should not be equated. N markers may differentially complement disease staging beyond amyloid and tau. Our findings suggest that Ng may not be an optimal N marker, given its low incongruency with tau pathophysiology.Highlights In Alzheimer's disease, neurogranin (Ng)+, neurofilament light (NfL)+, and hippocampal volume (HCV)+ showed differential protein expression in cerebrospinal fluid. Ng+ and NfL+ were associated with neuroplasticity, although in opposite directions. HCV+ showed few proteomic changes, related to oxidative stress. Neurodegeneration (N) markers may differentially refine disease staging beyond amyloid and tau. Ng might not be an optimal N marker, as it relates more closely to tau.

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CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

Delvenne,

Gobom,

Schindler

et al. 2024

Alzheimer's & Dementia

View full text Add to dashboard Cite

show abstract

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Brain Biomarkers: Follow-Up of RNA Expression Discovery Approach: CSF Assays for Neurogranin, SNAP-25, and VILIP-1

Cited by 1 publication

References 35 publications

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

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