Brain biopsy in primary angiitis of the central nervous system

Alrawi, Athear; Trobe, Jonathan D.; Blaivas, Mila; Musch, David C.

doi:10.1212/wnl.53.4.858

Cited by 248 publications

(179 citation statements)

References 7 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…10,25 In previous reports that included 10 or more adult cases of PCNSV (121 patients total), diagnosis was established by clinical or angiographic studies in 81 and by biopsy in 40. 8,17,21,26 -30 Lie's 8 and Alrawi and colleagues' 30 studies included only pathologically verified cases and accounted for all but 3 of the 40 tissuediagnosed cases. Lie 8 also noted the rarity of PCNSV in a tissue diagnosis; his 15 histologically proven cases were from a cohort of 1,337 patients with vasculitides of all types.…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system vasculitis: analysis of 101 patients

Salvarani

Brown

Calamia

et al. 2007

Annals of Neurology

562

578

View full text Add to dashboard Cite

Objective: To analyze the clinical findings, response to therapy, outcome, and incidence of primary central nervous system vasculitis (PCNSV) in a large cohort from a single center. Methods: We retrospectively studied 101 patients with PCNSV, selected by predetermined diagnostic criteria, who were seen during a 21-year period. This was a collaborative study by five departments at a large multispecialty clinic. Clinical findings and outcomes were compared among patients categorized by method of diagnosis, response to therapy, survival, and degree of disability. An annual incidence rate was calculated. Results: Seventy patients were diagnosed by angiography and 31 by central nervous system biopsy. Three histological patterns were observed during biopsy. Although most patients responded to therapy, an increased mortality rate was observed. Relapses occurred in one fourth of patients. Mortality rate and disability at last follow-up were greater in those who presented with a focal neurological deficit, cognitive impairment, cerebral infarctions, and angiographic large-vessel involvement but were lower in those with prominent gadolinium-enhanced lesions when evaluated by magnetic resonance imaging. The annual incidence rate of PCNSV was 2.4 cases per 1,000,000 person-years.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary central nervous system vasculitis: analysis of 101 patients

Salvarani

Brown

Calamia

et al. 2007

Annals of Neurology

562

578

View full text Add to dashboard Cite

show abstract

“…In the majority of patients with PACNS, abnormalities, albeit nonspecific, are present on cerebral angiograms (4). Brain biopsies in adult patients with PACNS frequently show granulomatous vasculitis of parenchymal and leptomeningeal arterial vessels in the brain (5); however, reports of nongranulomatous, lymphocytic CNS vasculitis have been published (6)(7)(8).…”

mentioning

confidence: 99%

Angiography‐negative primary central nervous system vasculitis in children: A newly recognized inflammatory central nervous system disease

Benseler¹,

deVeber²,

Hawkins³

et al. 2005

Arthritis & Rheumatism

146

110

View full text Add to dashboard Cite

Inflammatory central nervous system (CNS) diseases in childhood comprise a wide spectrum of heterogeneous conditions. We studied 4 children with primary CNS vasculitis in whom results of magnetic resonance imaging studies were abnormal but results of conventional angiography were normal. We determined that angiography-negative, biopsy-confirmed primary smallvessel CNS vasculitis is a previously unrecognized distinct disease entity in children. The diagnosis must be considered in a child with a progressive, acquired diffuse or focal neurologic deficit, even if the results of conventional angiography are normal. A lesional brain biopsy is required to confirm the diagnosis. Use of immunosuppressive therapy plus aspirin leads to an excellent neurologic outcome.

show abstract

“…Histological examination allows the definite diagnosis of PACNS. 1,15,17,19) Diagnostic biopsy shows transmural mononuclear inflammatory cells involving small vessels of the leptomeninges and/or parenchyma. 14,17) Three main histological patterns are reported, granulomatous, lymphocytic, and necrotizing vasculitis patterns.…”

Section: Discussionmentioning

confidence: 99%

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Tanei

Nakahara

Takebayashi

et al. 2011

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 60-year-old man presented with a rare case of primary angiitis of the central nervous system mimicking a tumor-like lesion and manifesting as slight disorientation, left hemiparesis, and motor aphasia. Computed tomography showed multiple low density lesions in the left frontal lobe, brain stem, and right parietal lobe. Magnetic resonance images revealed a slightly enhanced mass lesion in the right parietal lobe with surrounding brain edema. Serum, cerebrospinal fluid, and other image examinations did not show any abnormal findings, so surgical removal of the right parietal mass was performed. Histological examination revealed that the mass consisted of hemorrhagic infarction without cellular atypia. Proliferations of endothelial cells in small and medium arteries, and infiltration of macrophages in the perivascular space were detected in the infarction tissues. The histological diagnosis was primary angiitis of the central nervous system.

show abstract

Brain biopsy in primary angiitis of the central nervous system

Cited by 248 publications

References 7 publications

Primary central nervous system vasculitis: analysis of 101 patients

Primary central nervous system vasculitis: analysis of 101 patients

Angiography‐negative primary central nervous system vasculitis in children: A newly recognized inflammatory central nervous system disease

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Contact Info

Product

Resources

About