Brain Catecholamines and Ethanol: Involvement in Physical Dependence and Withdrawal

Comparative Effects of Ethanol and Malnutrition on the Development of Catecholamine Neurons: Changes in Neurotransmitter Levels

“…Ethanol appears to exert multiple effects on central catecholamine neurons. The observations of events mediated by acute or chronic administration of ethanol have seemed contradictory (Gurnsey and Olson, 1960;Corrodi et al, 1966;Carlsson et al, 1973;Hunt and Majchrowicz, 1974;Pohorecky, 1974Pohorecky, , 1977Karoum et al, 1976;Thadani et al, 1976;Thadani and Truitt, 1977;Liljequist, 1978;and Tabakoff and Hoffman, 1978). The toxic effects of an acute dose of ethanol are expressed differently in various parts of the brain (Bacopoulos et al, 1978).…”

Comparative Effects of Ethanol and Malnutrition on the Development of Catecholamine Neurons: Changes in Norepinephrine Turnover

“…Whether this lower norepinephrine concentration in brain at steady state is due solely to decreased rate of norepinephrine synthesis remains to be established. Studies on the rate of 3H incorporation into norepinephrine and its metabolites in animals previously injected with [JH]tyrosine, with or without the inhibition of norepinephrine-metabolizing systems (Pohorecky, 1974;1977), should answer this question.…”

Determinants of Chlormethiazole-Induced EEG Effects in Chronic Alcoholics

“…This holds true especially for the first examination term (Tl), shortly after cessation of acute ANS and CNS symptoms, like hallucinations, at which term the dose-effect relationship within the delta and theta power is characterized by delta augmentation only with patients not suffering from personality deterio ration and/or hallucinations, the 'sick' patients not show ing this effect. As there is sufficient evidence that these patients suffer from noradrenergic imbalance [Pohorecky, 1977], these effects can tentatively be interpreted as re equilibration in patients with severe (ANS?) postalco holic disturbance, and stronger sedation in patients with least imbalance.…”