Brain complications of diabetes mellitus: a cross‐sectional study of awareness among individuals with diabetes and the general population in Ireland

Dolan, Catherine; Glynn, Ronan W; Griffin, Stacy; Conroy, C.; Loftus, Christine T.; Wiehe, P. C.; Healy, M. J. R.; Lawlor, Brian A.

doi:10.1111/dme.13639

Cited by 25 publications

(20 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although both individuals with diabetes and their physicians are increasingly aware of cognitive dysfunction in relation to diabetes, this awareness still lags behind that of other diabetes complications [5]. Patients report that their healthcare providers sometimes have difficulty addressing cognitive dysfunction in relation to diabetes [6].…”

Section: Introductionmentioning

confidence: 99%

Cognitive dysfunction in diabetes: how to implement emerging guidelines

2019

View full text Add to dashboard Cite

Cognitive dysfunction, including mild cognitive impairment and dementia, is increasingly recognised as an important comorbidity and complication of diabetes that affects an individual’s well-being and diabetes management, and is associated with diabetes treatment-related complications. Recent guidelines therefore recommend screening for cognitive impairment in older individuals with diabetes. In addition, these guidelines suggest that glucose-lowering treatment should be tailored in those diagnosed with cognitive impairment, to reduce the risk of hypoglycaemia and improve treatment adherence. This review gives an overview of cognitive dysfunction in people with diabetes, briefly describing the clinical features of different stages of cognitive dysfunction and their epidemiology. In particular, it addresses essential additional steps that need to be taken to fully implement the emerging guidelines on screening and management of cognitive dysfunction in diabetes into daily practice.

show abstract

Section: Introductionmentioning

confidence: 99%

Cognitive dysfunction in diabetes: how to implement emerging guidelines

2019

View full text Add to dashboard Cite

show abstract

“…Moreover, chronic exposure to hyperglycemia can deteriorate cognitive function [ 8 ]. Hyperglycemia-induced impairment of cognitive function is considered a brain complication of diabetes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

et al. 2018

View full text Add to dashboard Cite

Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with high fat/high sugar diets and physical/mental stress can cause hyperglycemia, one of main characteristics of insulin resistance, metabolic syndrome, and diabetes. Hyperglycemia impairs organogenesis and induces organ abnormalities such as cardiac defect in utero. It is a risk factor for the development of metabolic diseases in adults. Resulting glucotoxicity affects peripheral tissues and vessels, causing pathological complications including diabetic neuropathy, nephropathy, vessel damage, and cardiovascular diseases. Moreover, chronic exposure to hyperglycemia can deteriorate cognitive function and other aspects of mental health. Recent reports have demonstrated that hyperglycemia is closely related to the development of cognitive impairment and dementia, suggesting that there may be a cause-effect relationship between hyperglycemia and dementia. With increasing interests in aging-related diseases and mental health, diabetes-related cognitive impairment is attracting great attention. It has been speculated that glucotoxicity can result in structural damage and functional impairment of brain cells and nerves, hemorrhage of cerebral blood vessel, and increased accumulation of amyloid beta. These are potential mechanisms underlying diabetes-related dementia. Nutrients and natural food components have been investigated as preventive and/or intervention strategy. Among candidate components, resveratrol, curcumin, and their analogues might be beneficial for the prevention of diabetes-related cognitive impairment. The purposes of this review are to discuss recent experimental evidence regarding diabetes and cognitive impairment and to suggest potential nutritional intervention strategies for the prevention and/or treatment of diabetes-related dementia.

show abstract

“…The patients were diagnosed with T2DM for ≥3 years according to the 1999 World Health Organization criteria (30). The exclusion criteria were as follows: (1) central nervous system diseases (i.e., recent stroke, head trauma, epilepsy, Parkinson's disease, depression, or other psychological illnesses) that may cause MCI; (2) drug or alcohol abuse or dependence; (3) other major illnesses, including cancer, anemia, or thyroid dysfunction; and (4) use of potential or known cognition-impairing drugs in the previous 3 months. All patients were of Chinese Han ethnic origin and provided written informed consent prior to their participation in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Individuals with type 2 diabetes mellitus (T2DM) exhibit a higher prevalence of mild cognitive impairment (MCI) in comparison with the general population (1). The risk of cognitive impairment in DM patients is 1.2 to 1.5-fold higher than that reported in non-DM individuals (2).…”

Section: Introductionmentioning

confidence: 99%

In Addition to Poor Glycemic Control, a High Level of Irisin in the Plasma Portends Early Cognitive Deficits Clinically in Chinese Patients With Type 2 Diabetes Mellitus

et al. 2019

View full text Add to dashboard Cite

Background and Objectives: Irisin plays an important role in the metabolism and homeostasis of energy balance, which is involved in cognitive impairment. This study aimed to investigate the role of irisin in mild cognitive impairment (MCI) among Chinese patients with type 2 diabetes mellitus (T2DM).Methods: We recruited 133 Chinese patients with T2DM, and divided them according to the Montreal Cognitive Assessment score. Demographic data were collected and the level of irisin in the plasma was determined. In addition, the results of neuropsychological testing were examined. The concentration of irisin in the plasma was measured using an enzyme immunoassay.Results: A total of 59 patients were diagnosed with MCI and 74 patients were included as healthy-cognition controls. The level of irisin in the plasma (p = 0.043) and homeostasis model of assessment for insulin resistance (p = 0.032) in diabetic patients with MCI were higher than those observed in the healthy controls. A higher level of irisin in the plasma was associated with impaired overall cognition, specifically executive function. Linear regression analysis suggested that irisin (p = 0.017) and glycosylated hemoglobin (p = 0.036) were independent factors of diabetic MCI.Conclusions: The level of irisin in the plasma correlated with cognitive impairment in T2DM patients, particularly with executive function. These results further suggest that, in addition to poor glycemic control, a high level of irisin in the plasma portends early cognitive deficits clinically in Chinese patients with T2DM.

show abstract

Brain complications of diabetes mellitus: a cross‐sectional study of awareness among individuals with diabetes and the general population in Ireland

Cited by 25 publications

References 22 publications

Cognitive dysfunction in diabetes: how to implement emerging guidelines

Cognitive dysfunction in diabetes: how to implement emerging guidelines

Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

In Addition to Poor Glycemic Control, a High Level of Irisin in the Plasma Portends Early Cognitive Deficits Clinically in Chinese Patients With Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About