2021
DOI: 10.1016/j.seizure.2021.06.028
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Brain concentrations of glutamate and GABA in human epilepsy: A review

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Cited by 105 publications
(67 citation statements)
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“…Epilepsy represents a group of neurological disorders characterized by recurrent seizures that can vary from brief absence episodes to continuous tonic–clonic motor activity. The seizures are a product of abnormal electrical activity of the brain, frequently caused by either excessive excitatory activity (glutamate) or reduced inhibitory control (GABA) [ 85 ]. Continued seizure activity may develop into SE, which is associated with both morbidity and mortality.…”
Section: Resultsmentioning
confidence: 99%
“…Epilepsy represents a group of neurological disorders characterized by recurrent seizures that can vary from brief absence episodes to continuous tonic–clonic motor activity. The seizures are a product of abnormal electrical activity of the brain, frequently caused by either excessive excitatory activity (glutamate) or reduced inhibitory control (GABA) [ 85 ]. Continued seizure activity may develop into SE, which is associated with both morbidity and mortality.…”
Section: Resultsmentioning
confidence: 99%
“…Synaptically released glutamate plays a major role in the initiation and spread of epileptic activity [57,58]. The modulation of glutamatergic signaling by mGluR agonists is a possible treatment strategy [59].…”
Section: Naag In Epilepsymentioning
confidence: 99%
“…Microtubule binding and GABA receptor binding are two Gene Ontology (GO) annotations for this gene. GABA and glutamate are the two major neurotransmitters that influence seizures, and the balance of the two neurotransmitters in the nervous system is particularly important for the prevention of epileptogenesis [ 48 ]. In another study on GRE, the authors found a disturbance in the glutamatergic neurotransmitter pathway [ 49 ].…”
Section: Discussionmentioning
confidence: 99%