2020
DOI: 10.21203/rs.3.rs-28495/v1
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Brain Connectivity and Behaviour in Post-Concussion Syndrome: A Scoping Review Protocol

Abstract: Background About 10-15% of patients experience persistent symptoms 3-months post-concussion, referred to as Post-Concussion Syndrome (PCS). There are no biomarkers for detecting this condition, but advanced neuroimaging tools such as Diffusion Tensor/Weighted Imaging (DTI/DWI) or functional MRI (fMRI) can detect subtle changes in the integrity of white matter tracts or brain activity, respectively. Methods This study protocol presents search strategies for a scoping review that provides an overview of the s… Show more

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“…"Plastic" neural re-organisations may have restored brain functioning despite cellular (e.g., metabolic) or molecular deficiencies. Indeed, humans with persistent post-concussive syndrome (PCS) show abnormal brain activation patterns [68,69], while those who recover from the PCS display frontal hyperactivations during executive function tasks [66,70]. This suggests that mechanisms of functional plasticity might compensate for long-term post-concussive brain dysfunctions, restoring their cognitive abilities.…”
Section: Plos Onementioning
confidence: 99%
“…"Plastic" neural re-organisations may have restored brain functioning despite cellular (e.g., metabolic) or molecular deficiencies. Indeed, humans with persistent post-concussive syndrome (PCS) show abnormal brain activation patterns [68,69], while those who recover from the PCS display frontal hyperactivations during executive function tasks [66,70]. This suggests that mechanisms of functional plasticity might compensate for long-term post-concussive brain dysfunctions, restoring their cognitive abilities.…”
Section: Plos Onementioning
confidence: 99%