Brain Connectivity Reduction Reflects Disturbed Self-Organisation of the Brain: Neural Disorders and General Anaesthesia

Hutt, Axel

doi:10.1007/978-3-030-18830-6_19

Cited by 1 publication

(1 citation statement)

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“…The functional connectivity between brain areas reflects the brain’s ability to pass and share information between the structures. For instance, brain networks in mental disorders exhibit diminished FC between brain areas and, thus, a network fragmentation [ 89 ]. Enhanced functional dysconnectivity has been found in early psychosis [ 90 ] and reduced conscious access in psychosis is related to diminished long-range structural connectivity [ 91 ], thus supporting the dysconnection hypothesis in schizophrenia [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Mathematical Model Insights into EEG Origin under Transcranial Direct Current Stimulation (tDCS) in the Context of Psychosis

Riedinger

Hutt

2022

JCM

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Schizophrenia is a psychotic disease that develops progressively over years with a transition from prodromal to psychotic state associated with a disruption in brain activity. Transcranial Direct Current Stimulation (tDCS), known to alleviate pharmaco-resistant symptoms in patients suffering from schizophrenia, promises to prevent such a psychotic transition. To understand better how tDCS affects brain activity, we propose a neural cortico-thalamo-cortical (CTC) circuit model involving the Ascending Reticular Arousal System (ARAS) that permits to describe major impact features of tDCS, such as excitability for short-duration stimulation and electroencephalography (EEG) power modulation for long-duration stimulation. To this end, the mathematical model relates stimulus duration and Long-Term Plasticity (LTP) effect, in addition to describing the temporal LTP decay after stimulus offset. This new relation promises to optimize future stimulation protocols. Moreover, we reproduce successfully EEG-power modulation under tDCS in a ketamine-induced psychosis model and confirm the N-methyl-d-aspartate (NMDA) receptor hypofunction hypothesis in the etiopathophysiology of schizophrenia. The model description points to an important role of the ARAS and the δ-rhythm synchronicity in CTC circuit in early-stage psychosis.

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