Brain control of dual-task walking can be improved in aging and neurological disease

Holtzer, Roee; Choi, Jaeun; Motl, Robert W.; Foley, Frederick W.; Wagshul, Mark E.; Hernandez, Manuel E.; Izzetoglu, Meltem

doi:10.1007/s11357-023-01054-3

GeroScience

2024

DOI: 10.1007/s11357-023-01054-3

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Brain control of dual-task walking can be improved in aging and neurological disease

Roee Holtzer,

Jaeun Choi,

Robert W. Motl

et al.

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2024

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Cited by 4 publications

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Obstacle Avoidance in Healthy Adults and People With Multiple Sclerosis: Preliminary fNIRS Study

Al-Shargie,

Glassen,

DeLuca

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Obstacle Avoidance in Healthy Adults and People With Multiple Sclerosis: Preliminary fNIRS Study

Al-Shargie,

Glassen,

DeLuca

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Brain hemodynamic responses and fall prediction in older adults with multiple sclerosis

Holtzer,

Foley,

Motl

et al. 2024

Mult Scler

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Objective: We examined whether brain hemodynamic responses, gait, and cognitive performances under single- and dual-task conditions predict falls during longitudinal follow-up in older adults with multiple sclerosis (OAMS) with relapsing-remitting and progressive subtypes. Methods: Participants with relapsing-remitting ( n = 53, mean age = 65.02 ± 4.17 years, %female = 75.5) and progressive ( n = 28, mean age = 64.64 ± 4.31 years, %female = 50) multiple sclerosis (MS) subtypes completed a dual-task-walking paradigm and reported falls during longitudinal follow-up using a monthly structured telephone interview. We used functional near-infrared spectroscopy (fNIRS) to assess oxygenated hemoglobin (HbO) in the prefrontal cortex during active walking and while performing a cognitive test under single- and dual-task conditions. Results: Adjusted general estimating equations models indicated that higher HbO under dual-task walking was significantly associated with a reduction in the odds of reporting falls among participants with relapsing-remitting (odds ratio (OR) = 0.472, p = 0.004, 95% confidence interval (CI) = 0.284–0.785), but not progressive (OR = 1.056, p = 0.792, 95% CI = 0.703–1.588) MS. In contrast, faster stride velocity under dual-task walking was significantly associated with a reduction in the odds of reporting falls among progressive (OR = 0.658, p = 0.004, 95% CI = 0.495–0.874), but not relapsing-remitting (OR = 0.998, p = 0.995, 95% CI = 0.523–1.905) MS. Conclusion: Findings suggest that higher prefrontal cortex activation levels during dual-task walking, which may represent compensatory reallocation of brain resources, provide protection against falls for OAMS with relapsing-remitting subtype.

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Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults With Multiple Sclerosis

Hernandez,

Motl,

Foley

et al. 2024

Neurorehabil Neural Repair

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Background Mobility and cognitive impairment are prevalent and co-occurring in older adults with multiple sclerosis (OAMS), yet there is limited research concerning the role of disability status in the cognitive control of gait among OAMS. Objective We investigated the levels of prefrontal cortex (PFC) activation, using oxygenated hemoglobin (HbO2), during cognitively-demanding tasks in OAMS with lower and higher disability using functional near-infrared spectroscopy (fNIRS) to: (1) identify PFC activation differences in single task walk and cognitively-demanding tasks in OAMS with different levels of disability; and (2) evaluate if disability may moderate practice-related changes in neural efficiency in OAMS. Methods We gathered data from OAMS with lower (n = 51, age = 65 ± 4 years) or higher disability (n = 48, age = 65 ± 5 years), using a cutoff of 3 or more, in the Patient Determined Disease Steps, for higher disability, under 3 different conditions (single-task walk, Single-Task-Alpha, and Dual-Task-Walk [DTW]) administered over 3 counterbalanced, repeated trials. Results OAMS who had a lower disability level exhibited decreased PFC activation levels during Single-Task-Walk (STW) and larger increases in PFC activation levels, when going from STW to a cognitively-demanding task, such as a DTW, than those with higher disability. OAMS with a lower disability level exhibited greater declines in PFC activation levels with additional within session practice than those with a higher disability level. Conclusions These findings suggest that disability moderates brain adaptability to cognitively-demanding tasks and demonstrate the potential for fNIRS-derived outcome measures to complement neurorehabilitation outcomes.

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Brain control of dual-task walking can be improved in aging and neurological disease

Cited by 4 publications

References 49 publications

Obstacle Avoidance in Healthy Adults and People With Multiple Sclerosis: Preliminary fNIRS Study

Obstacle Avoidance in Healthy Adults and People With Multiple Sclerosis: Preliminary fNIRS Study

Brain hemodynamic responses and fall prediction in older adults with multiple sclerosis

Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults With Multiple Sclerosis

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