Brain‐Derived Neurotrophic Factor and Peripheral Nerve Regeneration: A Functional Evaluation

Shirley, Diane M.; Williams, Sherri L.; Santos, Perry M.

doi:10.1097/00005537-199605000-00021

Cited by 33 publications

(21 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, recent studies have found no evidence that BDNF has an axonal promoting effect 50 or increases functional recovery. 51 Interpretation of these apparently conflicting studies is complicated by the fact that the doses of BDNF and methods of administration differ, which may explain some of the differences in results. NT-3 was recently proved to enhance peripheral nerve regeneration 52 through fibronectin mats.…”

Section: Neurotrophic Factors and Peripheral Nerve Regenerationmentioning

confidence: 99%

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

1998

View full text Add to dashboard Cite

The peripheral nervous system retains a considerable capacity for regeneration. However, functional recovery rarely returns to the preinjury level no matter how accurate the nerve repair is, and the more proximal the injury the worse the recovery. Among a variety of approaches being used to enhance peripheral nerve regeneration are the manipulation of Schwann cells and the use of neurotrophic factors. Such factors include, first, nerve growth factor (NGF) and the other recently identified members of the neurotrophin family, namely, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5); second, the neurokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF); and third, the transforming growth factors (TGFs)-beta and their distant relative, glial cell line-derived neurotrophic factor (GDNF). In this review article we focus on the roles in peripheral nerve regeneration of Schwann cells and of the neurotrophin family, CNTF and GDNF, and the relationship between these. Finally, we discuss what remains to be understood about the possible clinical use of neurotrophic factors.

show abstract

Section: Neurotrophic Factors and Peripheral Nerve Regenerationmentioning

confidence: 99%

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

1998

View full text Add to dashboard Cite

show abstract

“…Also, nerve recovery is promoted by the use of neurotrophic factors, including brain-derived neurotrophic factor (BDNF), platelet-rich plasma (PRP), and Matrigel (BD Biosciences, San Jose, CA) (a complex of extracellular matrix components, such as laminin, collagen IV, entactin, and heparin sulfate proteoglycan). [10][11][12][13] Mesenchymal stem cells (MSCs) are an attractive cell source for the regeneration of nerve tissue as they are able to self-renew and differentiate into diverse cell types. MSCs contain neurotrophic factors that are known as the other regeneration component of nerves.…”

Section: Introductionmentioning

confidence: 99%

Effect of neural‐induced mesenchymal stem cells and platelet‐rich plasma on facial nerve regeneration in an acute nerve injury model

et al. 2010

View full text Add to dashboard Cite

The use of PRP and/or nMSCs promotes facial nerve regeneration in an animal model of facial nerve axotomy. The use of nMSCs showed no benefit over the use of PRP in facial nerve regeneration, but the combined use of PRP and nMSCs showed a greater beneficial effect than use of either alone. This study provides evidence for the potential clinical application of PRP and nMSCs in peripheral nerve regeneration of an acute nerve injury. Laryngoscope, 2010.

show abstract

“…Adult motor neurons exhibit characteristic phenotypic changes following axotomy [89]. The administration of BDNF to transected axons does not affect the previous responses [90,95].…”

Section: Neurotrophic Factorsmentioning

confidence: 99%

Influence of Age on Regeneration in the Peripheral Nervous System

Kerezoudi

Thomas

1999

Gerontology

View full text Add to dashboard Cite

Studies on the influence of age on regeneration in the peripheral nervous system are reviewed. Observations in the human are limited, but clinical experience indicates that the efficiency of regeneration is less in later life. The results of experimental studies in animals, although sometimes variable, indicate a decline with age. This may be correlated with reduced axonal transport. At motor nerve terminals, the capacity to produce ultraterminal sprouting secondary to partial denervation is reduced, but not the capacity to eliminate terminal sprouts or reinnervation. Frequency and accuracy of reoccupation of the sites of motor nerve terminals are impaired. Nerve transection is more likely to result in loss of the parent neurons following nerve transection in young than in older animals. Chromatolysis is more intense and does not return to normal as rapidly in old animals, and the degree of retrograde axonal atrophy is less. This suggests a diminished dependence on peripheral growth factor support.

show abstract

Brain‐Derived Neurotrophic Factor and Peripheral Nerve Regeneration: A Functional Evaluation

Cited by 33 publications

References 16 publications

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

Schwann cells, neurotrophic factors, and peripheral nerve regeneration

Effect of neural‐induced mesenchymal stem cells and platelet‐rich plasma on facial nerve regeneration in an acute nerve injury model

Influence of Age on Regeneration in the Peripheral Nervous System

Contact Info

Product

Resources

About