2006
DOI: 10.1016/j.autneu.2006.02.027
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Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview

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Cited by 186 publications
(164 citation statements)
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References 89 publications
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“…Animal studies support the anorectic and satiating properties of BDNF, which, when administered centrally, induces appetite suppression and weight loss (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004). BDNF binds to its tropomyosin-related kinase B (TrkB) receptor (Noble et al, 2011) and modulates energy metabolism, food regulation and BMI by central as well as peripheral action, and regulates physical activity, hyperactivity, anxiety, and hyperphagia (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004). Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011).…”
Section: Discussionmentioning
confidence: 77%
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“…Animal studies support the anorectic and satiating properties of BDNF, which, when administered centrally, induces appetite suppression and weight loss (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004). BDNF binds to its tropomyosin-related kinase B (TrkB) receptor (Noble et al, 2011) and modulates energy metabolism, food regulation and BMI by central as well as peripheral action, and regulates physical activity, hyperactivity, anxiety, and hyperphagia (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004). Likewise, mutations in the genes coding for BDNF and TrkB are responsible for obesity and eating disorders (Lebrun et al, 2006;Noble et al, 2011).…”
Section: Discussionmentioning
confidence: 77%
“…Since the Met allele of the BDNF Val66Met genotype is associated with intracellular packaging and secretion of the proBDNF precursor, and sorting of BDNF into the nerve terminals, this "hypofunctional" Met allele reduces the activity-dependent BDNF secretion and therefore the production and amount of the mature BDNF (Chen et al, 2004;Egan et al, 2003). Animal studies support the anorectic and satiating properties of BDNF, which, when administered centrally, induces appetite suppression and weight loss (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004). BDNF binds to its tropomyosin-related kinase B (TrkB) receptor (Noble et al, 2011) and modulates energy metabolism, food regulation and BMI by central as well as peripheral action, and regulates physical activity, hyperactivity, anxiety, and hyperphagia (Lebrun et al, 2006;Noble et al, 2011;Rask-Andersen et al, 2010;Tapia-Arancibia et al, 2004).…”
Section: Discussionmentioning
confidence: 97%
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“…Intrathecal infusion of BDNF or pegylated BDNF caudal to thoracic spinal cord transection or contusive injury similarly promoted cholinergic axon sprouting, stimulated hindlimb air-stepping, and improved both hindlimb joint movements and Basso, Beattie, and Bresnahan open field locomotor rating scale scores [117,118]. To overcome limitations that would obviate using BDNF clinically, such as weight loss (reviewed in Lebrun et al [119]) and involvement in pain [120], we recently evaluated a monoclonal antibody (29D7) that has high affinity for TrkB, the receptor for BDNF [121]. Intrathecal 29D7 infusion caudal to cervical spinal cord dorsal quadrant lesions induced corticospinal tract axon sprouting rostral to the SCI and improved contralesional forelimb pellet retrieval recovery.…”
Section: Pharmacological and Gene-delivery Approachesmentioning
confidence: 99%