Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran

Rezaei, Sajjad; Mobarake, Karim Asgari; Saberi, Alia; Keshavarz, Parvaneh; Leili, Ehsan Kazemnejad

doi:10.1007/s10072-016-2520-2

Cited by 25 publications

(11 citation statements)

References 42 publications

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“…None of the individuals under study had the symptoms of respiratory diseases and chest lesions early in their employment. Examining mean inhalable flour dust concentration (38.773 ± 3.68 mg/m 3 ), it was determined that the extent of workers dust exposure with the allergen is tens of times further than its authorized threshold that recommended by the American Conference of Governmental Industrial Hygienists (TLV=0.5mg/m 3 ), [27,39,40] and it is also higher than the occupational exposure limits suggested by Technical Committee of Health Professionals of Iran. [28] As a corollary, based on the observations and results, it is expected that respiratory exposure to flour dust leads to respiratory diseases symptoms (cough, mucus, hoarse breath, chest wheeze, and asthma) outbreak and also the workers' PFC decrease.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Teimori¹

2018

AJP

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Background and Aim: Flour dust is one of the allergens dust in the workplaces, and its occupational exposure can cause respiratory impairments. The aim of this study was to investigate respiratory and pulmonary function problems in flour mills workers exposure to flour dust. Materials and Methods: This cross-sectional study was carried out at 11 flour-producing factories in Iran. Study subjects were including to 286 males (176 male workers with current exposure to flour dust and 110 male unexposed employees). Determination of dust concentration was carried out with personal dust sampler at all production wards of studied industries. Respiratory symptoms were investigated with American Thoracic Society questionnaire. Lung function tests were done by a calibrated spirometer. The statistical analysis was performed by SPSS 18 software and t-test, Chi-square, linear, and logistic regressions. Results: Age and job tenure means of exposed group were 35.2 ± 8.6 and 11.9 ± 6.03 years, respectively. This result, for unexposed group, too was gained 35.3 ± 8.5 and 10.89 ± 6.5 years, respectively. Atmospheric concentrations of respirable and inhalable dust were 12.4 ± 2.41 and 33.26 ± 3.47 mg/m 3 , respectively. These results indicated that prevalence of respiratory symptoms in exposed subjects was significantly higher than non-exposed workers. Likewise, pulmonary function parameters were significantly lower in exposed than the reference group. Conclusions: The findings of this study showed that occupational exposure to flour dust could be a significant factor of the prevalence of respiratory symptoms and functional disorders of the pulmonary.

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Section: Discussionmentioning

confidence: 99%

Untitled

Teimori¹

2018

AJP

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“…A worse response to rTMS in 44 post-stroke patients was also observed in Met-alle groups in comparison to the Val/Val group [52]. At least 6 months after both ischaemic-stroke and intracerebral haemorrhage, patients with Val/Met polymorphism were more likely to adapt to an aide, but this was tested in only 27 subjects [53]. The rTMS performed 6 months after the stroke onset in 22 patients with persistent paresis showed differences in their motor-evoked potentials, depending on their genotype status [50].…”

Section: Neurorehabilitation and Rs6265 Polymorphism Of The Bdnf Genementioning

confidence: 94%

The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients

Kotlęga

Peda

Zembroń-Łacny

et al. 2017

Neurologia i Neurochirurgia Polska

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Stroke is the main cause of motoric and neuropsychological disability in adults. Recent advances in research into the role of the brain-derived neurotrophic factor in neuroplasticity, neuroprotection and neurogenesis might provide important information for the development of new poststroke-rehabilitation strategies. It plays a role as a mediator in motor learning and rehabilitation after stroke. Concentrations of BDNF are lower in acute ischemic-stroke patients compared to controls. Lower levels of BDNF are correlated with an increased risk of stroke, worse functional outcomes and higher mortality. BDNF signalling is dependent on the genetic variation which could affect an individual's response to recovery after stroke. Several single nucleotide polymorphisms of the BDNF gene have been studied with regard to stroke patients, but most papers analyse the rs6265 which results in a change from valine to methionine in the precursor protein. Subsequently a reduction in BDNF activity is observed. There are studies indicating the role of this polymorphism in brain plasticity, functional and morphological changes in the brain. It may affect the risk of ischemic stroke, post-stroke outcomes and the efficacy of the rehabilitation process within physical exercise and transcranial magnetic stimulation. There is a consistent trend of Met alleles' being connected with worse outcomes and prognoses after stroke. However, there is no satisfactory data confirming the importance of Met allele in stroke epidemiology and the post-stroke rehabilitation process. We present the current data on the role of BDNF and polymorphisms of the BDNF gene in stroke patients, concentrating on human studies.

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“…We controlled vascular risk factors, such as blood pressure, blood lipids, blood sugar, and smoking, for each patient after stroke via anti‐hypertensive drugs, glucose lowering, and lipid lowering drugs. All patients underwent a standardized treatment based on the “Guideline for Early Management of Adults with Ischemic Stroke” 21 and were followed up in the outpatient clinic with the same clinician (H.Y.C., MD). All normal controls underwent cognitive assessment (both MMSE and miniCog) before the MRI scan.…”

Section: Methodsmentioning

confidence: 99%

Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia

Zhao

Cai

Huang

et al. 2021

Magnetic Resonance Imaging

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Background The hippocampus (HP) plays a critical role in memory and orientational functions and is functionally heterogeneous along the longitudinal anterior–posterior axis. Although the previous study has reported volumetric atrophy in hippocampal subfields of patients with poststroke dementia (PSD), how the functional connectivity (FC) is altered in these subfields remains unclear. Purpose To examine the FC changes of the HP subfields in patients with PSD. Study Type Prospective. Population Seventeen normal controls, 20 PSD, and 24 nondemented poststroke (PSND) patients. Field Strength/Sequence A 3.0 T/ T1‐weighted imaging, resting‐state functional and diffusion tensor imaging. Assessment We first segmented the HP using independent component analysis, and then used granger causality analysis to calculate the directed FCs (dFCs) between the subfields and the whole brain, and compared the dFCs among PSD, PSND, and controls. Statistical Tests Student's t‐test, chi‐square test, one‐way ANCOVA, multiple regression, support vector machine, multiple comparison correction, and reproducibility analysis. A P value < 0.05 was considered statistically significant. Results Our results showed HP was functionally divided into HPhead, HPbody, and HPtail bilaterally along the longitudinal axis. PSD patients showed significant dementia‐specific decreases in the inward information flow and increases in the outward information flow associated with the bilateral entire HP/HPhead and left HPbody (P < 0.05). Moreover, we observed significant correlations (P < 0.05) between the cognition score and the dFCs related to the bilateral entire HP and left HPhead in the PSD group. Furthermore, dFCs of the HP and its subfields improved the classification between the PSD and PSND patients (accuracy/sensitivity/specificity: 94%/95%/93%) compared to the clinical and demographic parameters alone. Data Conclusion These findings suggest that altered transmission and reception of information in the HP. These alternations were specific to individual subfields in PSD patients and may offer insight into the neurophysiological mechanisms underlying PSD. Evidence Level 1 Technical Efficacy Stage 2

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Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran

Cited by 25 publications

References 42 publications

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The role of brain-derived neurotrophic factor and its single nucleotide polymorphisms in stroke patients

Altered Functional Connectivity of Hippocampal Subfields in Poststroke Dementia

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