Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Tramontina, Juliana; Yates, Denise Balem; Magalhães, Pedro Vieira da Silva; Trentini, Clarissa M.; Sant’Anna, Marcia Kauer; Fries, Gabriel R.; Bock, Hugo; Saraiva-Pereira, Maria Luiza; Kapczinski, Flávio

doi:10.1590/s1516-44462009000200010

Cited by 21 publications

(22 citation statements)

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“…3 The authors found that the percentage of non-perseverative errors was significantly higher in Val/Val carriers, thus contradicting previous findings on cognitive impairment in Met allele carriers. 1,2 Considering the relationship between BDNF and processes of memory and learning, as well as the existence of episodic deficits in bipolar patients even when euthymic, 4,5 we launched an investigation into the relationship between the Val66Met polymorphism and the performance in verbal and visual episodic memory tasks (COEP UFMG process approval number 018/09).…”

mentioning

confidence: 60%

“…Thus, our initial results are partly different from those found by Tramontina et al These differences could be attributed to sample characteristics since bipolar disorder is a heterogeneous clinical condition and certain patient subgroups may exhibit more severe cognitive impairments than others. 3 Certain limitations of this study must be noted. The sample is small and all subjects were using pharmacological therapy during the study.…”

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confidence: 88%

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BDNF and episodic memory in patients with bipolar disorder

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Neves

Romano-Silva

et al. 2011

Rev. Bras. Psiquiatr.

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confidence: 60%

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confidence: 88%

BDNF and episodic memory in patients with bipolar disorder

Moreira

Neves

Romano-Silva

et al. 2011

Rev. Bras. Psiquiatr.

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“…One of the biological markers is the brain-derived neurotrophic factor (BDNF), a marker for central nervous system neuroplasticity. 39 This marker is associated with the effect of therapeutic molecules and it is utilized as a guide for indentifying new treatments. Considering the importance of growth factors in inflammation and oncology, the effects of BDNF are also being evaluated for use in such medical fields.…”

Section: Discussionmentioning

confidence: 99%

Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas

Hallak

Crippa

Quevedo

et al. 2010

Rev. Bras. Psiquiatr.

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Objective: Translational medicine has been described as the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve the understanding of medical disorders. In medicine, translational research offers an opportunity for applying the findings obtained from basic research to every-day clinical applications. The National Science and Technology Institute for Translational Medicine is comprised of six member institutions (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina and a core facility that serves all centers). The objectives of the project are divided into four areas: Institutional, Research, Human Resources and Technology for the Community and Productive Sector. Method: In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia. Conclusion: The main focus of the National Science and Technology Institute for Translational Medicine is the development of more useful methods that allow for a better application of basic research-based knowledge to the medical field. Descriptors

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“…Study examining 64 people with bipolar disorder, displayed significantly more non-perseverative errors in the group homozygous for Val allele [20]. Cunha et al showed that moderate BDNF overexpression in rats may lead to impaired learning in spatial and instrumental memory tasks.…”

Section: Brain-derived Neurotrophic Factor Val66met Polymorphism In Cmentioning

confidence: 99%

“…In some studies Met allele is considered to deteriorate cognitive functioning, while other studies do not present any significant associations between BDNF Val66Met and cognition [9,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

Bieliaski¹,

Lesiewska²,

Jaracz³

et al. 2018

Neuropsychiatry

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Neurothrophins are crucial in the regulation of many processes, such as nerve cells development and neuroplasticity and brain-derived neurothrophic factor (BDNF) is the major one. Researchers still scrutinize the role of BDNF Val66Met polymorphism in eating disorders and cognition, however, literature present inconsistent findings regarding this topic. Most of all, the exact mechanism of how exactly BDNF influences cognitive functioning in obesity is unknown. In our study, we try to elucidate the association of BDNF Val66Met polymorphism with executive functions and working memory on large obese population. 375 obese patients underwent biometric analyses and neuropsychological assessment. The Wisconsin Card Sorting Test (WCST) was used to assess cognitive functions. Genetic polymorphism in BDNF was evaluated in peripheral blood samples.Results indicated that both BDNF Val66Met polymorphism and gender showed significant correlations with BMI, WCST_P and WCST_CLR. Females showed higher BMI values than men,, however males scored higher in WSCT_P and WSCT_CLR. Val/Val carriers presented worse results of WCST and BMI. Kendall's partial rank correlation tests determined that both genotype and BMI showed significant correlations with WCST_CLR, WCST_CC and WCST_1st, in which BMI correlation was stronger. Analysis of mild and morbid obesity showed, that severe obese younger subjects presented worse WCST_P, WCST_NP, and WCST_CLR. Significant interaction effects for WCST parameters were found for gender, age, BMI and BDNF Val66Met. Importantly, in this study none Met/Met carriers were observed.The Val66Met BDNF polymorphism indirectly influenced the poorer cognitive functioning observed in the obese subpopulation with Val/Val genotype, rather than Val/Met genotype. A higher BMI was associated with the Val allele, suggesting that obesity may have deteriorated the activity of the prefrontal cortex. According to results, BDNF Val66Met polymorphism seems to contribute to greater obesity in our study. It is greater BMI, rather than genotype, which caused worse executive functioning and working memory. KeywordsVal66Met BDNF, Neurothrophins, Obesity Neuropsychiatry (London) (2018) 8(1) 112Research Maciej Bieliński the worse scores in WCST, and how BDNF Val66Met influences the severity of obesity. Materials and Methods ParticipantsA total of 375 adult Caucasian patients of Polish nationality were enrolled in this study, including 233 women and 142 men, after excluding secondary reasons of obesity. The mean age of all participants was 54 (range, 20-76) years old; the mean age for women was 52 (20-75) years old, and for men 56 (42-67) years old. The exclusion criteria were individuals with a severe somatic or psychiatric disorder included in the Diagnostic

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Brain-derived neurotrophic factor gene val66met polymorphism and executive functioning in patients with bipolar disorder

Cited by 21 publications

References 23 publications

BDNF and episodic memory in patients with bipolar disorder

BDNF and episodic memory in patients with bipolar disorder

Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas

Brain-Derived Neurotrophic Factor Val66Met Polymorphism in Contex of Executive Functions and Working Memory in Obese Patients

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