Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract

Shpak, A.A.; Guekht, Alla; Дружкова, Т. А.; Kozlova, Ksenia; Gulyaeva, N. V.

doi:10.1080/02713683.2017.1396617

Cited by 51 publications

(59 citation statements)

References 50 publications

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“…Clinically, investigators in Iran reported that serum BDNF concentrations decreased more in primary open angle glaucoma (POAG) and NTG patients than in normal patients 14,15 . Recently, similar results were reported from Italy 16 , Turkey 17 , and Russia 18 . BDNF is transported retrogradely from the superior colliculus to the RGCs, and this transport is substantially inhibited by acute IOP elevation 1 .…”

Section: Introductionsupporting

confidence: 81%

“…Various studies have pointed out the importance of BDNF in glaucoma [14][15][16][17][18][19][20][21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…Elevated IOP is the most important known risk factor for glaucoma, but lowering IOP is not always sufficient to halt the progression of the optic neuropathy, particularly in NTG, suggesting the involvement of neuroprotective factors such an BDNF in the pathology of NTG. Although the serum BDNF in glaucoma patients has already been reported [14][15][16][17][18] , there have been no studies performed in northeast Asia, where NTG is the most common type of glaucoma. In this study, the levels of BDNF in the serum of POAG and NTG patients in Japan were evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

et al. 2020

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Purpose. The aim of this study was to measure the serum levels of brain-derived neurotrophic factor (BDNF) in primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients in Japan. Methods. This was a prospective, observational study that examined serum BDNF levels in 78 patients who underwent cataract surgery or trabeculectomy (27 glaucoma patients and 51 non-glaucoma cataract patients as controls). The patients' age was 68.8 ± 11.1 years (mean ± standard deviation; range 35-86 years). The number of patients with POAG and NTG was 16 and 11, respectively. The diagnosis of POAG was done by intraocular pressure measurement, gonioscopy, optic nerve head change, and the presence of a visual field defect. Results. The serum BDNF concentration was significantly lower in the glaucoma group, including both POAG and NTG, than in the control group (7.2 ± 3.6 ng/mL vs. 12.2 ± 9.3 ng/mL, p=0.004). The serum BDNF concentration was lower in the early phase than in the moderate phases of glaucoma. There was no correlation between the serum BDNF concentration and age. When the NTG and POAG patient groups were compared, the serum BDNF concentration was lower in NTG patients than in POAG patients. No significant correlations were found between glaucoma parameters, including optical coherence tomography and visual field defects, and the serum BDNF concentration. Conclusion. This is the first study to have investigated serum BDNF concentrations in glaucoma patients in Japan. Further investigations are needed to evaluate the role of BDNF as a potential biomarker of glaucoma.

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Section: Introductionsupporting

confidence: 81%

“…Various studies have pointed out the importance of BDNF in glaucoma [14][15][16][17][18][19][20][21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

et al. 2020

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“…In the study of Shpak et al, 55 investigating BDNF levels in primary open angle glaucoma, age-related cataract, and healthy subjects, they did not find any significant difference in the BDNF levels of lacrimal fluid (LF) and the serum of healthy controls and patients with cataract, confirming that age-related cataract has little or no effect on the BDNF level in the LF and serum. They also determined a strong correlation of BDNF levels in AH and LF, suggesting that age-related cataract does not influence BDNF level in AH as well, and they suggested that data of patients with age-related cataract could be used as normative data.…”

Section: Discussionmentioning

confidence: 93%

Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses

Tekin

Şekeroğlu

Demirtaş

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine brain-derived neurotrophic factor (BDNF) levels in serum and aqueous humor (AH) and to assess the relationship between BDNF levels and retinal layer thicknesses in age-related macular degeneration (AMD). METHODS.A total of 48 AMD patients (AMD group) that was composed of twenty-three nonexudative and 25 exudative patients and 26 control subjects (control group) were included in the study. Serum and AH BDNF levels were assessed by ELISA method. Retinal layer thicknesses were calculated by segmentation analysis of optical coherence tomography. RESULTS.The mean BDNF levels in AH were found to be significantly lower in both the nonexudative and exudative AMD groups than in the control group (P ¼ 0.003 and P < 0.001, respectively). Optical coherence tomography segmentation analysis revealed that the total average retina pigment epithelium thickness was statistically significantly thinner in the nonexudative AMD group compared with the exudative AMD and control groups (P ¼ 0.001 and P ¼ 0.040, respectively). The total average outer nuclear layer (ONL) thicknesses of nonexudative and exudative AMD cases were reduced compared to control group; however, the decrement was statistically significant only in the nonexudative AMD group (P ¼ 0.009). In the correlation analysis of BDNF levels with retinal layer thicknesses, statistically significant correlations exist between BDNF levels of AH with ONL thicknesses in cases of AMD and with retina pigment epithelium thicknesses in the nonexudative AMD group.CONCLUSIONS. BDNF concentrations in AH decreased in the AMD group and this decrease correlates with outer retinal layer thicknesses. Low BDNF levels detected in the AMD group may be insufficient to protect the photoreceptors, resulting in thinning of ONL.

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“…Studies have reported on different biologic substances in the LF, implying that the changes in the concentration in LF could be indicative of changes in the substances’ intraocular levels. For example, a decrease in the BDNF level in LF in glaucoma was regarded as a possible indicator of the BDNF decline in the eye [ 36 ], although such an assumption has not been justified. Therefore, the second objective of this study was to determine the interrelations between CNTF concentrations in the eye (in AH) and in LF.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophic factors in patients with primary open-angle glaucoma and age-related cataract. Part 1. Ciliary neurotrophic factor

Shpak¹,

Гехт²,

Дружкова³

et al. 2018

JOS

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PurposeTo study the ciliary neurotrophic factor (CNTF) concentration in the aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) in patients with age-related cataract and primary open-angle glaucoma (POAG).MethodsCNTF concentrations were studied in 61 patients with age-related cataract, 55 patients with POAG combined with cataract, and 29 healthy controls (one eye in each person). Preliminary experiments permitted us to extend the minimum quantifiable value of the CNTF Quantikine enzyme-linked immunosorbent assay (ELISA) kit to 2.5 pg/ml.ResultsThe levels of CNTF in LF and BS did not differ in patients with cataract and controls. The CNTF concentration (pg/ml) in patients with POAG and cataract was lower than in patients with cataract (p<0.001) in AH (39.9±26.2 versus 57.2±25.6) and in LF (25.7±14.9 versus 39.9±18.0). The differences were not statistically significant for the CNTF level in BS (5.45±4.72 versus 5.96±4.92) and the AH/LF ratio (1.69±1.05 versus 1.58±0.70). In the patients with POAG, the AH level of CNTF correlated with the visual field index (Pearson’s correlation coefficient r = 0.35, p = 0.01). A statistically significant decrease in the AH and LF concentrations of CNTF was observed in patients in all stages of POAG compared with the cataract group. This decrease was particularly prominent in patients with severe glaucoma. Compared to patients with combined early and moderate stages of disease patients with advanced glaucoma showed an insignificant reduction in the median CNTF concentration in AH and LF. The serum CNTF concentration did not show any dependence on the glaucoma stage. The CNTF concentration in the AH strongly correlated with the CNTF concentration in the LF (r=0.71, p<0.000). A formula was suggested to calculate the concentration of CNTF in AH based on the CNTF concentration in LF.ConclusionsThe CNTF concentration is reduced in the AH and LF of patients with POAG, especially in those with severe visual field loss. The CNTF concentration in AH and LF showed a strong correlation, and this phenomenon opens up new options for a noninvasive estimation of the CNTF concentration in AH. The CNTF concentration established in the AH, LF, and BS of patients with age-related cataract can serve as normative data for persons older than 50 years old.

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Brain-Derived Neurotrophic Factor in Patients with Primary Open-Angle Glaucoma and Age-related Cataract

Abstract: BDNF contents are decreased in AH, LF, and BS of patients with POAG demonstrating a significant decrease in the early POAG and relative increase in the next stages of the disease. A strong correlation exists between BDNF contents in AH and LF.

Cited by 51 publications

References 50 publications

Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study

Brain-Derived Neurotrophic Factor in Patients With Age-Related Macular Degeneration and Its Correlation With Retinal Layer Thicknesses

Neurotrophic factors in patients with primary open-angle glaucoma and age-related cataract. Part 1. Ciliary neurotrophic factor

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