2022
DOI: 10.1016/j.nlm.2022.107656
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Brain derived neurotrophic factor in perioperative neurocognitive disorders: Current evidence and future directions

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Cited by 8 publications
(6 citation statements)
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“…[82] However, BDNF levels are associated with neural network plasticity related to learning memory capacity and cannot be used as a blood marker of neuroinflammation. [82]…”
Section: Resultsmentioning
confidence: 99%
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“…[82] However, BDNF levels are associated with neural network plasticity related to learning memory capacity and cannot be used as a blood marker of neuroinflammation. [82]…”
Section: Resultsmentioning
confidence: 99%
“…[81] Pro-inflammatory cytokines can inhibit BDNF signaling by activating p38 mitogen-activated protein kinase and nuclear factor-κB (NF-κB), resulting in reduced neurogenesis and neuroplasticity. [82] However, BDNF levels are associated with neural network plasticity related to learning memory capacity and cannot be used as a blood marker of neuroinflammation. [82] Peripheral benzodiazepine receptors 28 were found to be associated with long-term persistence of cognitive impairment after abdominal surgery.…”
Section: Surgerymentioning
confidence: 99%
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“…As this review included only outcomes with available meta-analyses, additional risk factors where meta-analyses are currently unavailable were not explored. For instance, a secondary surgical procedure [ 56 ] or additional biomarkers such as cortisol and brain-derived neurotrophic factor may be risk factors for POCD [ 57 , 58 ]; however, these have not been included in any previous meta-analyses.…”
Section: Discussionmentioning
confidence: 99%
“…It is the most widely distributed neurotrophic factor in the brain and is required for the growth, survival, and differentiation of many neurons 2 . Thus, it is known that higher levels of BDNF in brain tissue and blood have been associated with better cognitive function, as it is a crucial molecule involved in plastic changes related to learning and memory 3 . However, in aging‐dependent cognitive impairment and aged brains, 4 psychiatric disorders, 5,6 and neurodegenerative pathologies, 7,8 people develop abnormalities in brain function and have lower levels of BDNF.…”
Section: Introductionmentioning
confidence: 99%