Brain‐derived neurotrophic factor (<scp>BDNF</scp>) in children with <scp>ASD</scp> and their parents: a 3‐year follow‐up

Francis, Konstantinos; Dougali, A.; Sideri, Kyriaki; Kroupis, Christos; Vasdekis, Vassilis G. S.; Dima, K.; Douzenis, Athanasios

doi:10.1111/acps.12872

Cited by 22 publications

(13 citation statements)

References 56 publications

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“…Recently, de novo mutations in TrkB were identified in individuals with ASD [55]. Abnormal BDNF levels in the cortex [37], hippocampus [37], striatum [3536], and serum [56] were reported in ASD. The results of those studies suggest that the BDNF and TrkB receptor system correlates with ASD.…”

Section: Discussionmentioning

confidence: 99%

Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee

Han

2019

Exp Neurobiol

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Section: Discussionmentioning

confidence: 99%

Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee

Han

2019

Exp Neurobiol

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“…However, clinical data on neurotrophic factor levels in children with ASD have yielded inconsistent results. One study showed that the serum BDNF levels of children with ASD were significantly higher than that of the control subjects 13 , whereas Makkonen et al 14 suggested that was no significant difference in serum BDNF concentrations between cases and controls, and another study showed that BDNF serum levels were significantly decreased in ASD children when compared with controls 15 . For VEGF, results from Emanuele et al showed that VEGF levels in patients with ASD were lower than that of healthy controls 16 .…”

Section: Shu-han Liu Xiao-jie Shi Fang-cheng Fan and Yong Cheng *mentioning

confidence: 99%

Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

Liu

Xiao

Fan

et al. 2021

Sci Rep

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Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD). However, clinical data on neurotrophic factor levels in children with ASD were inconsistent. Therefore, we performed a systematic review of peripheral blood neurotrophic factors levels in children with ASD, and quantitatively summarized the clinical data of peripheral blood neurotrophic factors in ASD children and healthy controls. A systematic search of PubMed and Web of Science identified 31 studies with 2627 ASD children and 4418 healthy controls to be included in the meta-analysis. The results of random effect meta-analysis showed that the peripheral blood levels of brain-derived neurotrophic factor (Hedges’ g = 0.302; 95% CI = 0.014 to 0.591; P = 0.040) , nerve growth factor (Hedges’ g = 0.395; 95% CI = 0.104 to 0.686; P = 0.008) and vascular endothelial growth factor (VEGF) (Hedges’ g = 0.097; 95% CI = 0.018 to 0.175; P = 0.016) in children with ASD were significantly higher than that of healthy controls, whereas blood neurotrophin-3 (Hedges’ g = − 0.795; 95% CI = − 1.723 to 0.134; P = 0.093) and neurotrophin-4 (Hedges’ g = 0.182; 95% CI = − 0.285 to 0.650; P = 0.445) levels did not show significant differences between cases and controls. Taken together, these results clarified circulating neurotrophic factor profile in children with ASD, strengthening clinical evidence of neurotrophic factor aberrations in children with ASD.

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“…Furthermore, Bryn et al 30 found increased plasma levels of BDNF in children with ASD compared with age-and sex-matched controls, observing that BDNF levels were particularly high in children with intellectual disability. In addition, all ASD patients enrolled in studies whose results revealed normal or low BDNF levels were intellectually normal or had, at least, an IQ over 70 24,27 .…”

Section: Discussionmentioning

confidence: 99%

“…As a result of this assumption, a growing number of articles, reviews and meta-analysis have appeared evaluating the possible changes in BDNF blood levels in ASD [19][20][21][22] . However, the results of the studies have been inconsistent, some evidencing reduced BDNF serum [23][24][25][26][27] , while a larger number of other studies have shown elevated BDNF serum levels in children with ASD as compared to healthy controls 8,11,20,[28][29][30][31][32] . Additionally, studies evaluating levels of BDNF in neonates who subsequently evolved to an ASD also revealed inconsistent results [33][34][35][36][37][38] .…”

mentioning

confidence: 99%

Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder

Barbosa

Pratesi

Paz

et al. 2020

Sci Rep

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There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neurotrophic factor (BDNF). The objective of the present study was to analyze BDNF serum concentration levels in children with classic forms autism and a healthy control group to determine if there is a correlation between ASD and BDNF serum levels. Forty-nine children with severe classic form of autism, and 37 healthy children were enrolled in the study. Blood samples, from both patients and controls, were collected and BNDF levels from both groups were analyzed. The average BDNF serum concentration level was statistically higher for children with ASD (P < 0.000) compared to the control group. There is little doubt that BDNF plays a role in the pathophysiology of ASD development and evolution, but its brain levels may fluctuate depending on several known and unknown factors. The critical question is not if BDNF levels can be considered a prognostic or diagnostic marker of ASD, but to determine its role in the onset and progression of this disorder.

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Brain‐derived neurotrophic factor (BDNF) in children with ASD and their parents: a 3‐year follow‐up

Abstract: Our results contradict those from recent published meta-analyses with the age, the presence of ID and allergies being possible contributing factors. The parents' data indeed point to a role of BDNF in the pathophysiology of ASD.

Cited by 22 publications

References 56 publications

Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder

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