Brain-Derived Neurotrophic Factor Val/Met Polymorphism and Bipolar Disorder

Kim, Byungsu; Kim, Chang Yoon; Hong, Jin Pyo; Kim, Seong Yoon; Lee, Chul; Joo, Young Hoon

doi:10.1159/000162356

Cited by 67 publications

(16 citation statements)

References 109 publications

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“…BDNF 196A was shown to be a risk factor for suicide in some studies conducted among psychiatric populations [11,12,13,14,15]. In our study, we found a protective effect of the BDNF 196A-carrying genotypes on attempted suicide in the elderly population.…”

Section: Discussionsupporting

confidence: 73%

“…However, their results do not agree. Five studies [11,12,13,14,15] found that the 196A allele was a risk factor for suicidal behavior, while a further 2 studies [16,17] suggested that the 196G allele was the primary risk factor for attempted suicide. On the other hand, other studies [9,18,19,20] did not support the association of the BDNF G196A polymorphism and suicidal behavior.…”

Section: Introductionmentioning

confidence: 99%

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Association of Brain-Derived Neurotrophic Factor G196A and Attempted Suicide: A Case-Control Study in Rural China

Wang

Wang²,

Wang³

et al. 2015

Neuropsychobiology

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Background: Suicide is an important public problem, the mechanism of which has not been clarified. Many studies have focused on the molecular, biological and genetic mechanisms of suicide. Brain-derived neurotrophic factor (BDNF) G196A is one of the most leading loci in recent studies, but the results are inconsistent. Methods: We conducted a 1:1 age- and sex-matched case-control study in rural areas of Shandong Province, China. A total of 365 pairs of cases and controls were finally recruited into our study. The adjusted odds ratios (AORs) of BDNF 196G/G and their 95% confidence intervals (CIs) were calculated by multivariate conditional logistic regression models. Results: No association between BDNF polymorphisms and attempted suicide was found in the overall population. However, the BDNF 196G/G genotype was significantly related to attempted suicide in the elderly population (AOR = 7.85, 95% CI: 1.12-54.90, p = 0.038), while the associations were not significant in young and middle-aged groups. Conclusion: Our study suggests that the BDNF 196G/G genotype increases the risk of attempted suicide in elderly people.

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Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Association of Brain-Derived Neurotrophic Factor G196A and Attempted Suicide: A Case-Control Study in Rural China

Wang

Wang²,

Wang³

et al. 2015

Neuropsychobiology

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“…Altamura et al (2010), Baumann et al (1999), Bellivier et al (2000), Benedetti et al (2011), Berrettini et al (1986), Campos et al (2010), D’Ambrosio et al (2012), De Luca et al (2005a, 2005b, 2006, 2009), Dowlatshahi et al (1999), Dracheva et al (2008), Evans et al (2012), Feldcamp et al (2008), Finseth et al (2014), Jimenez et al (2013), Kamali et al (2012), Kim et al (2002, 2007, 2008), Le-Niculescu et al (2013), Leszczynska-Rodziewicz et al (2014), Lopez et al (2007), Mahon et al (2012), Malloy-Diniz et al (2011), Matsuo et al (2010), Monfrim et al (2014), Nery et al (2014), Nery-Fernandes et al (2012), Neves et al (2008, 2010), Park et al (2013), Perlis et al (2012), Pinto et al (2011), Pompili et al (2008), Shabani et al (2013), Sher et al (2006, 2012), Singhal et al (2014), Souery et al (2001), Stange et al (2014), Suttajit et al (2013), Thibodeau et al (2013), Tidemalm et al (2014), Tochigi et al (2008), Tsai et al (1999a), Vuksan-Cusa et al (2009) and Willour et al (2012).…”

Section: Figurementioning

confidence: 99%

Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder

Schaffer

Isometsä

Tondo

et al. 2015

Aust N Z J Psychiatry

140

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Objectives Bipolar disorder is associated with elevated risk of suicide attempts and deaths. Key aims of the International Society for Bipolar Disorders Task Force on Suicide included examining the extant literature on epidemiology, neurobiology and pharmacotherapy related to suicide attempts and deaths in bipolar disorder. Methods Systematic review of studies from 1 January 1980 to 30 May 2014 examining suicide attempts or deaths in bipolar disorder, with a specific focus on the incidence and characterization of suicide attempts and deaths, genetic and non-genetic biological studies and pharmacotherapy studies specific to bipolar disorder. We conducted pooled, weighted analyses of suicide rates. Results The pooled suicide rate in bipolar disorder is 164 per 100,000 person-years (95% confidence interval = [5, 324]). Sex-specific data on suicide rates identified a 1.7:1 ratio in men compared to women. People with bipolar disorder account for 3.4–14% of all suicide deaths, with self-poisoning and hanging being the most common methods. Epidemiological studies report that 23–26% of people with bipolar disorder attempt suicide, with higher rates in clinical samples. There are numerous genetic associations with suicide attempts and deaths in bipolar disorder, but few replication studies. Data on treatment with lithium or anticonvulsants are strongly suggestive for prevention of suicide attempts and deaths, but additional data are required before relative anti-suicide effects can be confirmed. There were limited data on potential anti-suicide effects of treatment with antipsychotics or antidepressants. Conclusion This analysis identified a lower estimated suicide rate in bipolar disorder than what was previously published. Understanding the overall risk of suicide deaths and attempts, and the most common methods, are important building blocks to greater awareness and improved interventions for suicide prevention in bipolar disorder. Replication of genetic findings and stronger prospective data on treatment options are required before more decisive conclusions can be made regarding the neurobiology and specific treatment of suicide risk in bipolar disorder.

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“…They did not find any significant association of Val66Met polyorphism and suicidality in bipolar patients of Chinese origin. Recently, Kim et al191 examined BDNF Val/Met polymorphism in bipolar disorder in Korean subjects and whether clinical features vary according to genotype. They found that allelic distributions did not differ significantly between bipolar patients and healthy normal controls; however, the rate of suicide attempts among the Val/Val, Val/Met, and Met/Met genotype groups was significantly different.…”

Section: Bdnf In Suicidementioning

confidence: 99%

Brain-derived neurotrophic factor: role in depression and suicide

Dwivedi¹

2009

NDT

306

207

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Depression and suicidal behavior have recently been shown to be associated with disturbances in structural and synaptic plasticity. Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, plays an important role in the maintenance and survival of neurons and in synaptic plasticity. Several lines of evidence suggest that BDNF is involved in depression, such that the expression of BDNF is decreased in depressed patients. In addition, antidepressants up-regulate the expression of BDNF. This has led to the proposal of the “neurotrophin hypothesis of depression”. Increasing evidence demonstrates that suicidal behavior is also associated with lower expression of BDNF, which may be independent from depression. Recent genetic studies also support a link of BDNF to depression/suicidal behavior. Not only BDNF, but abnormalities in its cognate receptor tropomycin receptor kinase B (TrkB) and its splice variant (TrkB.T1) have also been reported in depressed/suicidal patients. It has been suggested that epigenetic modulation of the Bdnf and Trkb genes may contribute to their altered expression and functioning. More recently, impairment in the functioning of pan75 neurotrophin receptor has been reported in suicide brain specimens. pan75 neurotrophin receptor is a low-affinity neurotrophin receptor that, when expressed in conjunction with low availability of neurotropins/Trks, induces apoptosis. Overall, these studies suggest the possibility that BDNF and its mediated signaling may participate in the pathophysiology of depression and suicidal behavior. This review focuses on the critical evidence demonstrating the involvement of BDNF in depression and suicide.

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Brain-Derived Neurotrophic Factor Val/Met Polymorphism and Bipolar Disorder

Cited by 67 publications

References 109 publications

Association of Brain-Derived Neurotrophic Factor G196A and Attempted Suicide: A Case-Control Study in Rural China

Association of Brain-Derived Neurotrophic Factor G196A and Attempted Suicide: A Case-Control Study in Rural China

Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder

Brain-derived neurotrophic factor: role in depression and suicide

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