Brain donation for research: Who donates and why?

Garrick, Thomas; Howell, Stuart; Terwee, P; Redenbach, J.; Blake, Helen L.; Harper, Clive

doi:10.1016/j.jocn.2005.06.014

Cited by 29 publications

(22 citation statements)

References 10 publications

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“…These studies indicate that the most common reasons for being involved were; to benefit science, to benefit medicine and to benefit the community. These are similar to motivating factors that are reported in the transplant literature (Garrick et al 2006). Other research that has arisen from the UoB program is the establishment of demographically adjusted normative data for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in an Australian context.…”

Section: Discussionsupporting

confidence: 59%

“…The DIBS is a semistructured instrument designed for post-mortem psychiatric assessment using medical records and informants where possible. This instrument enables diagnosis at a sub-syndrome and symptom-based level, providing comprehensive information for prospective research, while increasing the reliability of clinical diagnosis (Garrick et al 2006;Keks et al 1999).…”

Section: Diagnostic Characterization Of Dofm Casesmentioning

confidence: 99%

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An Australian Brain Bank: a critical investment with a high return!

Sheedy

Garrick

Dedova

et al. 2008

Cell Tissue Banking

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Research into neuropsychiatric disorders, including alcohol-related problems, is limited in part by the lack of appropriate animal models. However, the development of new technologies in pathology and molecular biology means that many more questions can be addressed using appropriately stored human brain tissues. The New South Wales Tissue Resource Centre (TRC) in the University of Sydney (Australia) is a human brain bank that can provide tissues to the neuroscience research community studying alcohol-related brain disorders, schizophrenia, depression and bipolar disorders. Carefully standardised operational protocols and integrated information systems means that the TRC can provide high quality, accurately characterised, tissues for research. A recent initiative, the pre-mortem donor program called "Using our Brains", encourages individuals without neuropsychiatric illness to register as control donors, a critical group for all research. Community support for this program is strong with over 2,000 people registering their interest. Discussed herein are the protocols pertaining to this multifaceted facility and the benefits of investment, both scientific and financial, to neuroscience researchers and the community at large.

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Section: Discussionsupporting

confidence: 59%

Section: Diagnostic Characterization Of Dofm Casesmentioning

confidence: 99%

An Australian Brain Bank: a critical investment with a high return!

Sheedy

Garrick

Dedova

et al. 2008

Cell Tissue Banking

Self Cite

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“…Altruism is frequently mentioned in most organ donation literature (Azizi et al 2006;Garrick et al 2006). 'Altruism' can be defined as 'the belief that acting for the benefit of others is right and good'.…”

Section: Discussionmentioning

confidence: 99%

“…The 'Gift of Hope' brain donor program and the 'Using our Brains' donor program both emphasize the need to engage the NOK in the consent process (Boyes and Ward 2003;Garrick et al 2006). Both programs openly invite questions from the NOK to ensure that as much as possible is known about the process of brain donation to assist in facilitating the donation at the time of death.…”

Section: Introductionmentioning

confidence: 99%

“…Both programs openly invite questions from the NOK to ensure that as much as possible is known about the process of brain donation to assist in facilitating the donation at the time of death. The main motivating factors identified by donors enrolled in the pre-mortem programs were the desire to help others-with an illness and without an illnessand to support medical research (Boyes and Ward 2003;Garrick et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Factors that influence decisions by families to donate brain tissue for medical research

et al. 2009

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Whilst mainstream transplant literature provides valuable insights into the influences on families to donate organs and tissues for transplant, the relevance of these findings in relation to organ donation for research remain speculative. The present study aims to expand the research donation literature, by exploring factors that influence a family's decision to donate brain tissue to neuroscience research. The verbal responses of the senior available next-of-kin (NOK), to the question of brain donation for research, are analysed. The donation rate was high (54%) over the 5-year-period. NOK relationship to the deceased, and post mortem interval were the main factors associated with a positive donation. Parents were most likely to donate and this may result from a lifetime of decision-making on behalf of the deceased. Also, the longer the interval between death of the potential donor and the question being asked, the greater the likelihood of donation.

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Perceptions and Attitudes toward Brain Donation among the Chinese People

Zhāng

Deng

et al. 2019

Anatomical Sciences Ed

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Postmortem human brain donation is crucial to both anatomy education and research. The China Human Brain Banking Consortium was established recently to foster brain donation in China. The purpose of this study was to gain information about the public perception of and attitudes toward brain donation and to identify factors that may impact the willingness to participate in brain donation among the Chinese people. A specifically designed questionnaire was delivered to community residents in Changsha (the capital city of Hunan province) with a total of 1,249 completed forms returned and statistically analyzed. The majority of the participants considered that brain donation would help medical research and education, and 32.0% of respondents agreed that the brain donation would help change the traditional Chinese funeral belief in keeping the body intact after death. However, participants aged over 60 years old were less supportive of this concept. Among all participants, 63.7% stated that they were not knowledgeable about brain donation, while 26.4% explicitly expressed a willingness to participate in brain donation. Age, gender, monthly household income, and knowledge about brain donation significantly affected the willingness. Compared with other age groups, a higher proportion of participants aged over 60 years old preferred to be informed by a medical college. To promote brain donation in China, especially among the elderly, better communication of its medical benefits and a reinterpretation of the Confucius view of the human body should be provided. Efforts are also needed to provide appropriate forums and sources of brain donation information to targeted communities and society in general.

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Brain donation for research: Who donates and why?

Cited by 29 publications

References 10 publications

An Australian Brain Bank: a critical investment with a high return!

An Australian Brain Bank: a critical investment with a high return!

Factors that influence decisions by families to donate brain tissue for medical research

Perceptions and Attitudes toward Brain Donation among the Chinese People

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