Brain eigenfrequency shifting as a sensitive index of cerebral compliance in an experimental model of epidural hematoma in the rabbit

Douzinas, E.; Kostopoulos,; Kypriades, E.M.; Pappas, Y.Z.; Lymberis, A; Karmpaliotis, DI; Katsouyanni, Klea; Andrianakis, Ilias; Papalois, Αpostolos; Roussos, Charis

doi:10.1097/00003246-199905000-00040

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…Esse mesmo método foi realizado com êxito por Douzinas et al (1999) (Çagavi et al, 2005). Nesses animais, foi realizada a craniotomia descompressiva e verificado deslocamento do cerebelo através do forame magno, caracterizando herniação foraminal.…”

Section: Resultsunclassified

Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos

Aiello

Andrades

Ripplinger

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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RESUMO O objetivo deste estudo foi utilizar a sonda uretral flexível como método alternativo para aferição da pressão intracraniana em coelhos com trauma cranioencefálico induzido pelo cateter de Fogarty 4 Fr (balão epidural) e comparar os dados obtidos com o método convencional de cateter de ventriculostomia. Foram utilizados 12 coelhos, machos, adultos, distribuídos aleatoriamente em dois grupos, denominados de G1: mensuração da PIC com cateter de ventriculostomia (n=6) e G2: mensuração com sonda uretral (n=6). Foram realizadas duas craniotomias na região parietal direita e esquerda para a implantação do cateter de ventriculostomia ou sonda uretral flexível e o balão epidural, respectivamente. A PAM, a PPC, a FC, a FR e a TR foram mensurados antes e após a craniotomia. A PIC foi avaliada após a craniotomia e a cada 10 minutos depois do preenchimento do balonete com 0,3mL de NaCl 0,9%, durante 40 minutos, e com 0,6mL, pelo mesmo período de tempo, totalizando 80 minutos. A PIC aumentou em ambos os grupos, sendo menores os valores registrados com a sonda uretral flexível. Foi possível reproduzir o aumento da PIC com o modelo experimental de TCE utilizando o cateter de Fogarty 4 Fr na região epidural e, embora haja a necessidade de outros estudos, a sonda uretral flexível demonstra ser um método alternativo de mensuração da PIC em coelhos com trauma cranioencefálico.Palavras-chave: cateter de ventriculostomia, autorregulação, neurologia, cirurgia ABSTRACT The aim of this study was to evaluate the use of flexible urethral catheter as an alternative method for measuring intracranial pressure in rabbits with head trauma induced by 4 F Fogarty catheter (epidural balloon) and compare the data obtained with the conventional method of ventriculostomy catheter. In this study, New Zealand rabbits were randomly distributed into two groups, G1: measuring the ICP with ventriculostomy catheter (n=6) and G2: measuring the ICP with urethral catheter (n=6

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Section: Resultsunclassified

Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos

Aiello

Andrades

Ripplinger

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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“…In all rabbits, we facilitated the reproduction of an epidural hematoma that consequently resulted in brain tamponade [17]. Briefly, the central auricular artery and marginal ear vein were cannulated.…”

Section: Methodsmentioning

confidence: 99%

“…In this experimental study, we have used a previously established model of TBI in rabbits which has been developed by our group [17]. In the aforementioned model, a 5-Fr balloon-tipped catheter is placed in the epidural space of rabbits, while gradual infusion of autologous blood results in the reproduction of a mass effect due to the implanted epidural hematoma [17].…”

Section: Introductionmentioning

confidence: 99%

“…In the aforementioned model, a 5-Fr balloon-tipped catheter is placed in the epidural space of rabbits, while gradual infusion of autologous blood results in the reproduction of a mass effect due to the implanted epidural hematoma [17]. In this model, we have invasively evaluated the ICP, during the epidural hematoma formation until the Cushing reaction was established.…”

Section: Introductionmentioning

confidence: 99%

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Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits

Kasapas

Diamantopoulou

Pentilas

et al. 2014

The Scientific World Journal

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Introduction. An experimental epidural hematoma model was used to study the relation of ultrasound indices, namely, transcranial color-coded-Doppler (TCCD) derived pulsatility index (PI), optic nerve sheath diameter (ONSD), and pupil constriction velocity (V) which was derived from a consensual sonographic pupillary light reflex (PLR) test with invasive intracranial pressure (ICP) measurements. Material and Methods. Twenty rabbits participated in the study. An intraparenchymal ICP catheter and a 5F Swan-Ganz catheter (SG) for the hematoma reproduction were used. We successively introduced 0.1 mL increments of autologous blood into the SG until the Cushing reaction occurred. Synchronous ICP and ultrasound measurements were performed accordingly. Results. A constant increase of PI and ONSD and a decrease of V values were observed with increased ICP values. The relationship between the ultrasound variables and ICP was exponential; thus curved prediction equations of ICP were used. PI, ONSD, and V were significantly correlated with ICP (r 2 = 0.84 ± 0.076, r 2 = 0.62 ± 0.119, and r 2 = 0.78 ± 0.09, resp. (all P < 0.001)). Conclusion. Although statistically significant prediction models of ICP were derived from ultrasound indices, the exponential relationship between the parameters underpins that results should be interpreted with caution and in the current experimental context.

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“…However, the reality is much different, as it has been shown by Douzinas et al, (1999), since the eigenfrequency pattern exhibits a more complex behavior.…”

Section: Introductionmentioning

confidence: 97%

A new method for the early diagnosis of brain edema/brain swelling. An experimental study in rabbits

Kostopoulos

Douzinas

Kypriades

et al. 2006

Journal of Biomechanics

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Brain eigenfrequency shifting as a sensitive index of cerebral compliance in an experimental model of epidural hematoma in the rabbit

Cited by 8 publications

References 14 publications

Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos

Sonda uretral flexível como método alternativo para aferição invasiva da pressão intracraniana em trauma cranioencefálico induzido em coelhos

Invasive and Ultrasound Based Monitoring of the Intracranial Pressure in an Experimental Model of Epidural Hematoma Progressing towards Brain Tamponade on Rabbits

A new method for the early diagnosis of brain edema/brain swelling. An experimental study in rabbits

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