Brain electrical dysfunction of the anterior cingulate in schizophrenic patients

Fallgatter, Andreas J.; Bartsch, Andreas J.; Zielasek, J.; Herrmann, Martin J.

doi:10.1016/s0925-4927(03)00072-6

Cited by 55 publications

(44 citation statements)

References 62 publications

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“…Based on such findings, the NGA has been suggested to be an electrophysiological correlate of cognitive response control and a neurophysiological marker of ACC function, even though other brain regions, particularly within the prefrontal cortex, are likely to be involved as well (eg Ford et al, 2004). In accordance with the hypofrontality concept, schizophrenic patients were found to have a significantly diminished NGA (Fallgatter and Mueller, 2001) and a reduced activation of the ACC during Nogo conditions (Fallgatter et al, 2003), findings that are again largely in line with electrophysiological (Kopp and Rist, 1999;Strandburg et al, 1999;Kiehl et al, 2000;Weisbrod et al, 2000;Mathalon et al, 2002) and neuroimaging data (Volz et al, 1999;Carter et al, 2001;Rubia et al, 2001;Laurens et al, 2003).…”

Section: Introductionsupporting

confidence: 74%

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

Ehlis

Reif

Herrmann

et al. 2006

Neuropsychopharmacol

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The enzyme catechol-O-methyltransferase (COMT) has attracted increasing interest regarding a genetic disposition towards schizophrenias and as a modulator of prefrontal brain function. A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. An impact of COMT genotype on cognition has been well established; however, the exact nature of this influence has yet to be elucidated. The aim of this study was to determine whether COMT genotype affects an electrophysiological marker of prefrontal activation and neuropsychological frontal lobe measures in schizophrenia. To this end, 56 acutely psychotic in-patients with schizophrenia spectrum disorders were investigated. Patients with the COMT 1947AA (Met/Met) genotype (n ¼ 13) were compared to a carefully matched sample of patients with a G1947A (Val/Met) genotype (n ¼ 15); matching criteria included patients' age, handedness, gender distribution, diagnosis, and medication status. A small group of six homozygous Val allele carriers was additionally included to allow an assessment of possible gene-dosage effects. P300 amplitudes and latencies, as well as an electrophysiological marker of prefrontal brain function (NoGo-Anteriorization/NGA) and neuropsychological measures (Stroop Test, Verbal Fluency, Trail Making Test) were regarded. Homozygous Met allele carriers had significantly increased NGA values and fronto-central Nogo amplitudes compared to patients with at least one Val allele. They also tended to perform better in the Stroop task, as compared to the matched group of Val/Met patients. These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders.

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Section: Introductionsupporting

confidence: 74%

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

Ehlis

Reif

Herrmann

et al. 2006

Neuropsychopharmacol

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“…One way to further investigate these functional consequences is to correlate DTNBP1 gene variants with measurements of functional intermediate phenotypes (endophenotypes), which are well characterized in healthy subjects and disturbed in schizophrenic patients. These two prerequisites are particularly true for the NGA, a robust and reliable ERP marker of prefrontal brain function that has been described disturbed with markedly reduced NGA in patients with schizophrenias Fallgatter et al, 2003). In this context, the significantly reduced NGA in healthy subjects with the G/G variant of SNP P1765 as well as the C/C variant of SNP P1320 may be cautiously interpreted as an expression of mildly disturbed prefrontal brain function.…”

Section: Discussionmentioning

confidence: 99%

“…This missing behavioral effect might be explained by the easiness of the applied task with very long interstimulus intervals (1650 ms) and presentation times (200 ms). This particularly undemanding task has been designed to produce clearcut electrophysiological results, but is rather unsuited for the detection of performance differences between different patient samples and control subjects (eg schizophrenias: Fallgatter et al, 2003;writer's cramp: Berg et al, 2001;ADHD: Fallgatter et al, 2005a;OCD: Herrmann et al, 2003). It is therefore plausible to expect differences in the brain function without accompanying behavioral effects when comparing two healthy samples with this particular task.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, patients with schizophrenias Fallgatter et al, 2003) are characterized by a diminished NGA indicating an altered function of the medial prefrontal cortex. Concordant alterations of brain function were obtained when investigating patients with obsessive-compulsive disorders and attention-deficit hyperactivity disorder (ADHD; Fallgatter et al, 2004, Fallgatter et al, 2005a.…”

Section: Introductionmentioning

confidence: 99%

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DTNBP1 (Dysbindin) Gene Variants Modulate Prefrontal Brain Function in Healthy Individuals

Fallgatter

Herrmann

Hohoff

et al. 2006

Neuropsychopharmacol

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DTNBP1 (dysbindin) is one of the several putative schizophrenia genes supported by association, neuroanatomical, and cellular studies. These suggest an involvement of DTNBP1 in the prefrontal cortex and cognitive functions mediated by interaction with neurotransmitter systems, in particular glutamate. The influence of DTNBP1 gene variation on prefrontal brain function at the systemic neurophysiological level, though, has not been characterized. The NoGo-anteriorization (NGA) as an event-related potential (ERP) measure elicited during the continuous performance test (CPT) has been established as a valid neurophysiological parameter for prefrontal brain function in healthy individuals and patients with schizophrenias. In the present study, we therefore investigated the influence of eight dysbindin gene variants on the NGA as a marker of prefrontal brain function in 48 healthy individuals. Two DTNBP1 polymorphisms previously linked to schizophrenia (P1765 and P1320) were found associated with changes in the NGA. Post hoc analysis showing an influence of genetic variation at these loci on the Go centroid and frontal amplitudes suggest that this might be due to modification of the execution of motor processes by the prefrontal cortex. This is the first report on a role of DTNBP1 gene variation for prefrontal brain function at a systemic neurophysiological level in healthy humans. Future studies will have to address the relevance of this observation for patients with schizophrenias.

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“…In sLORETA, the intracerebral volume was divided into 6,239 voxels at 5-mm spatial resolution. The sLORETA computed the standardized current density at each of the 6,239 voxels in a realistic head model under the assumption that activations of neighboring neural structures would be similar to target sources (Fallgatter, Bartsch, Zielasek, & Herrmann, 2003;Fuchs, Kastner, Wagner, Hawes, & Ebersole, 2002;Mazziotta et al, 2001;Scharmüller, Leutgeb, Schäfer, Këchel, & Schienle, 2011). The source activation of the ERP waveform was calculated for each participant, using a statistical nonparametric mapping method that was provided by the sLORETA toolbox.…”

Section: Physiological Recording and Analysismentioning

confidence: 99%

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

Park¹,

Moon²,

Kim

et al. 2012

Cogn Affect Behav Neurosci

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A previous study has shown that greater cardiac vagal tone, reflecting effective self-regulatory capacity, was correlated with superior visual discrimination of fearful faces at high spatial frequency Park et al. (Biological Psychology 90:171-178, 2012b). The present study investigated whether individual differences in cardiac vagal tone (indexed by heart rate variability) were associated with different event-related brain potentials (ERPs) in response to fearful and neutral faces. Thirty-six healthy participants discriminated the emotion of fearful and neutral faces at broad, high, and low spatial frequencies, while ERPs were recorded. Participants with low resting heart rate variability-characterized by poor functioning of regulatory systems-exhibited significantly greater N200 activity in response to fearful faces at low spatial frequency and greater LPP responses to neutral faces at high spatial frequency. Source analyses-estimated by standardized low-resolution brain electromagnetic tomography (sLORETA)-tended to show that participants with low resting heart rate variability exhibited increased source activity in visual areas, such as the cuneus and the middle occipital gyrus, as compared with participants with high resting heart rate variability. The hyperactive neural activity associated with low cardiac vagal tone may account for hypervigilant response patterns and emotional dysregulation, which heightens the risk of developing physical and emotional problems.

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Brain electrical dysfunction of the anterior cingulate in schizophrenic patients

Cited by 55 publications

References 62 publications

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

Impact of Catechol-O-Methyltransferase on Prefrontal Brain Functioning in Schizophrenia Spectrum Disorders

DTNBP1 (Dysbindin) Gene Variants Modulate Prefrontal Brain Function in Healthy Individuals

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

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