Brain Energy Consumption Induced by Electrical Stimulation Promotes Systemic Glucose Uptake

Binkofski, Ferdinand; Loebig, Michaela; Jauch‐Chara, Kamila; Bergmann, Sigrid; Melchert, Uwe H.; Scholand-Engler, Harald G.; Schweiger, Ulrich; Pellerin, Luc; Oltmanns, Kerstin M.

doi:10.1016/j.biopsych.2011.05.009

Cited by 66 publications

(86 citation statements)

References 33 publications

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“…We have previously demonstrated that tDCS increases systemic glucose tolerance in normal-weight volunteers and that glucose infusion rates relate to respective changes in the high-energy phosphate content (9). Despite the obvious relationship between cerebral energy metabolism and systemic glucose uptake, how the two are linked is not entirely clear.…”

Section: Discussionmentioning

confidence: 99%

“…Supporting this view is the finding that cerebral ATP and PCr levels predict the amount of calories subsequently consumed (8). Moreover, brain energy consumption by electrical stimulation increases glucose tolerance in normal-weight men (9). On this basis, we aimed to test whether transcranial direct current stimulation (tDCS), a form of neurostimulation that uses constant low current delivered directly to the brain by small electrodes, would improve the characteristic glucose-intolerant state in obese volunteers.…”

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confidence: 99%

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Blunted Brain Energy Consumption Relates to Insula Atrophy and Impaired Glucose Tolerance in Obesity

et al. 2015

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Brain energy consumption induced by electrical stimulation increases systemic glucose tolerance in normalweight men. In obesity, fundamental reductions in brain energy levels, gray matter density, and cortical metabolism, as well as chronically impaired glucose tolerance, suggest that disturbed neuroenergetic regulation may be involved in the development of overweight and obesity. Here, we induced neuronal excitation by anodal transcranial direct current stimulation versus sham, examined cerebral energy consumption with 31 P magnetic resonance spectroscopy, and determined systemic glucose uptake by euglycemic-hyperinsulinemic glucose clamp in 15 normal-weight and 15 obese participants. We demonstrate blunted brain energy consumption and impaired systemic glucose uptake in obese compared with normal-weight volunteers, indicating neuroenergetic dysregulation in obese humans. Broadening our understanding of reduced multifocal gray matter volumes in obesity, our findings show that reduced appetite-and taste-processing area morphometry is associated with decreased brain energy levels. Specifically, gray matter volumes of the insula relate to brain energy content in obese participants. Overall, our results imply that a diminished cerebral energy supply may underlie the decline in brain areas assigned to food intake regulation and therefore the development of obesity.The incidence and prevalence of obesity have been escalating worldwide, and obesity has already reached epidemic proportions (1,2). This frightening development, in conjunction with the urgent need to replace more-or-less inefficient treatment strategies, has resulted in the development of new pathophysiological concepts of obesity. There is currently a growing consensus that this disease involves dysregulation within brain areas assigned to control food intake behavior and systemic energy homeostasis (3,4). Data show that complex neuronal pathways with reciprocal connections between the hypothalamus, brainstem, and higher cortical centers control appetite and food intake behavior (5), whereas afferent inputs from the periphery as well as efferent signals to peripheral organs regulate energy homeostasis (6). At large, appetite perception, food intake behavior, and energy homeostasis are synchronized in the hypothalamus as the cerebral "appetite center" (3,4). In this context, lower levels of high-energy phosphates (i.e., ATP and phosphocreatine [PCr]), have been detected in obese compared with normal-weight humans (7), which suggests a relationship between brain energy supply and body weight regulation. Supporting this view is the finding that cerebral ATP and PCr levels predict the amount of calories subsequently consumed (8). Moreover, brain energy consumption by electrical stimulation increases glucose tolerance in normal-weight men (9). On this basis, we aimed to test

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Blunted Brain Energy Consumption Relates to Insula Atrophy and Impaired Glucose Tolerance in Obesity

et al. 2015

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“…Two papers have explored the impact of tDCS on bioenergetics using Phosphorus MRS (Binkofski et al, 2011;Rae et al, 2013). Unfortunately, the stimulation protocol and outcome measures reported for each were different negating the possibility of a meaningful comparison.…”

Section: Omitted Measuresmentioning

confidence: 98%

Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review

2015

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“…Em outro estudo de espectroscopia, CLARK et al 47 realizaram 30 minutos de estimulação anódica no lobo parietal direito, observando um aumento nos níveis de glutamato e glutamina nestas regiões. Também utilizando espectroscopia, em um desenho cross-over em 15 voluntários saudáveis, um outro estudo verificou que estimulação anódica causava depleção dos níveis de fósforo31, indicando depleção energética e, portanto, aumento de atividade neuronal 48 . Finalmente, STAGG et al 45 , também utilizando espectroscopia, verificaram que a estimulação anódica levava a uma diminuição de níveis de GABA, enquanto que a estimulação catódica levava a redução de atividade glutamatérgica, acompanhada de uma redução de GABA.…”

Section: Neuroimagemunclassified

Estimulação cerebral na promoção da saúde e melhoria do desempenho físico

Okano

Montenegro

Farinatti

et al. 2013

Rev. bras. educ. fís. esporte

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Brain Energy Consumption Induced by Electrical Stimulation Promotes Systemic Glucose Uptake

Cited by 66 publications

References 33 publications

Blunted Brain Energy Consumption Relates to Insula Atrophy and Impaired Glucose Tolerance in Obesity

Blunted Brain Energy Consumption Relates to Insula Atrophy and Impaired Glucose Tolerance in Obesity

Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review

Estimulação cerebral na promoção da saúde e melhoria do desempenho físico

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