Abstract:This study used Event-related Potentials (ERPs) to examine the difference between three issue types (related, foil, and unrelated issues) and two reaction types (honesty and deception reaction). This was a subject-in design. Two sets of data were collected. First, the behavior data showed that the reaction time of the deception was 200ms slower than that of honesty, and the decreasing order of the reaction time on three designed issue types was foil issues, unrelated issues, and related issues. Second, the EEG data showed that related issues produce the most significant ERPs effect; the obvious wave separation of honesty reaction was between 300ms to 800ms versus 200ms to 500ms in experiment of deception; the deception reaction could evoke distinct P300, which was most obvious in left parietal lobes such as FC3, C3, CP3, P3; P3 was more sensitive in the time window of 200ms to 400ms, honesty reaction evoked obvious positive wave whereas deception evoked negative wave. In conclusion, the reaction time of deception was significantly slower than honesty. Moreover, deception evoked the obvious P300 effect. Based on the waveform evoked by different issue types, left parietal lobe waveform could be used as judgement of honesty or deception, and the correlation between suspect and the case could be decided.