Brain functional abnormality in drug treated and drug naïve adolescents with borderline personality disorder: Evidence for default mode network dysfunction

Salgado‐Pineda, Pilar; Ferrer, Marc; Calvo, Natàlia; Costa, Xavier Besalú; Ribas, Núria; Lara, Benjamín; Tarragona, Brenda; Fuentes‐Claramonte, Paola; Salvador, Raymond; Pomarol‐Clotet, Edith

doi:10.1016/j.jpsychires.2023.03.012

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…In contrast, Aguilar-Ortiz et al [17] examined 67 adult BPD patients and 67 healthy controls during performance of the n-back working memory task and found reduced deactivation in the patients in the medial frontal cortex and the precuneus, as well as in the inferior temporal cortex and hippocampus/parahippocampal gyrus. This finding was partly replicated by Salgado-Pineda et al [18] in a group of adolescent patients with BPD who had not received any psychopharmacological treatment.…”

Section: Introductionmentioning

confidence: 58%

Brain Functional Correlates of Recall of Life Events in Medication-Naïve Adolescents with Borderline Personality Disorder

Salgado-Pineda,

Ferrer,

Calvo

et al. 2024

Neuropsychobiology

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Introduction: Recall of autobiographical events has been found to be impaired in borderline personality disorder (BPD), but few studies have examined if this impairment has brain functional correlates. This study evaluated brain functional alterations during autobiographical recall using medication-naive adolescent patients to avoid potential confounding effects of treatment. Methods: Thirty-two adolescent female patients with BPD who were never-medicated and without psychiatric comorbidity and 33 matched healthy females underwent fMRI while they viewed individualized cue words that evoked autobiographical memories. Control conditions included viewing non-memory-evoking cues and a low-level baseline (cross-fixation). Results: During autobiographical recall, in comparison to the low-level baseline, the BPD patients showed increased brain activity in regions including the posterior hippocampus, the lingual and calcarine cortex, and the precuneus compared to the healthy controls. The BPD patients also showed a failure to deactivate the right dorsolateral prefrontal cortex during autobiographical recall. No patient-control differences were found when memory-evoking words were compared to non-memory-evoking words. Discussion/Conclusions: This study finds evidence of hippocampal/lingual/calcarine/precuneus hyperactivation to stimuli that evoke autobiographical memories in patients with BPD. As the changes were seen in never-treated patients without other comorbidities, they could be considered intrinsic to the disorder. Our study also adds to existing evidence for failure of deactivation in BPD, this time outside the default mode network.

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Section: Introductionmentioning

confidence: 58%

Brain Functional Correlates of Recall of Life Events in Medication-Naïve Adolescents with Borderline Personality Disorder

Salgado-Pineda,

Ferrer,

Calvo

et al. 2024

Neuropsychobiology

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Brain functional abnormality in drug naïve adolescents with borderline personality disorder during self- and other-reflection

Salgado-Pineda,

Ferrer,

Calvo

et al. 2024

Preprint

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A disturbed sense of identity is one of the major features of borderline personality disorder (BPD), which manifests early in the course of the disorder, and is potentially examinable using functional imaging during tasks involving self-reflection. Twenty-seven medication-naïve adolescent female patients with BPD, who had no psychiatric comorbidities, and 28 matched healthy female controls underwent fMRI while answering questions about themselves or an acquaintance. Control conditions consisted of answering questions involving factual knowledge and a low-level baseline (cross-fixation). When self-reflection was compared to fact processing, BPD patients exhibited reduced activation in the right dorsolateral prefrontal cortex (DLPFC), as well as in the left parietal and calcarine cortex and the right precuneus. In contrast, other-reflection was associated with relatively lower activation in the medial frontal cortex in BPD patients, with further analysis revealing that this change reflected a failure of de-activation during the fact processing condition. There were no differences between the BPD patients and controls when self- and other-processing was examined against low-level baseline. This study provides evidence of reduced DLPFC activation during self-reflection in adolescent females with BPD, which may reflect diminished top-down cognitive control of this process in the disorder.

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Brain functional abnormality in drug treated and drug naïve adolescents with borderline personality disorder: Evidence for default mode network dysfunction

Cited by 2 publications

References 49 publications

Brain Functional Correlates of Recall of Life Events in Medication-Naïve Adolescents with Borderline Personality Disorder

Brain Functional Correlates of Recall of Life Events in Medication-Naïve Adolescents with Borderline Personality Disorder

Brain functional abnormality in drug naïve adolescents with borderline personality disorder during self- and other-reflection

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