Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: A systematic review

Mancuso, Lorenzo; Uddin, Lucina Q.; Nani, Andrea; Costa, Tommaso; Cauda, Franco

doi:10.1016/j.neubiorev.2019.07.004

Cited by 36 publications

(26 citation statements)

References 207 publications

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“…The corpus callosum plays a crucial role in interhemispheric functional connectivity, as it is the main white matter structure that connects the brain's hemispheres. Indeed, the properties of the corpus callosum are significantly related to homotopic connectivity (De Benedictis et al, 2016;Mancuso et al, 2019;Tobyne et al, 2016). Despite the demonstrated link between aerobic fitness and the corpus callosum, we did not find a clear evidence of a connection between aerobic fitness and homotopic connectivity.…”

Section: Discussioncontrasting

confidence: 80%

“…The corpus callosum has been shown to play an important role in the interhemispheric exchange of information (van der Knaap & van der Ham, 2011). Specifically, the corpus callosum has been suggested as a significant underlying structure in terms of affecting homotopic connectivity, which refers to functional connectivity among homologous brain locations across the hemispheres (De Benedictis et al, 2016;Mancuso et al, 2019;Tobyne et al, 2016). Despite these similarities, it is not yet known whether physical activity and aerobic fitness also relates to the homotopic functional connectivity of the brain.…”

Section: Introductionmentioning

confidence: 99%

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Physical activity is positively related to local functional connectivity in adolescents’ brains

Ruotsalainen

Glerean

Karvanen

et al. 2020

Preprint

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Adolescents have experienced decreased aerobic fitness levels and insufficient physical activity levels over the past decades. While both physical activity and aerobic fitness are related to physical and mental health, little is known concerning how they manifest in the brain during this stage of development, characterized by significant physical and psychosocial changes. Previous investigations have demonstrated associations of physical activity and aerobic fitness with the brain's functional connectivity in both children and adults. However, it is difficult to generalize these results to adolescents because the development of functional connectivity has unique features during adolescence. Here, we examined how physical activity and aerobic fitness are associated with local and interhemispheric functional connectivity of the adolescent brain, as measured with resting-state functional magnetic resonance imaging (fMRI). Physical activity was measured by hip-worn accelerometers, and aerobic fitness by a maximal 20-m shuttle run test. We found that higher levels of moderate-to-vigorous physical activity, but not aerobic fitness, were linked to increased local functional connectivity as measured by regional homogeneity in 13-16-year-old participants. However, we did not find evidence for significant associations between adolescents' physical activity or aerobic fitness and interhemispheric connectivity, as indicated by homotopic connectivity. These results suggest that physical activity, but not aerobic fitness, is related to local functional connectivity in adolescents. Moreover, physical activity shows an association with a specific brain area involved in motor functions but did not display any widespread associations with other brain regions. These results can advance our understanding of the behavior-brain associations in adolescents.

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Physical activity is positively related to local functional connectivity in adolescents’ brains

Ruotsalainen

Glerean

Karvanen

et al. 2020

Preprint

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“…Experiments show that when the callosum is severed, a strong suppression of inter-hemispheric FC occurs (Mancuso et al, 2019;Roland et al, 2017 ;O'Reilly et al, 2013) , in agreement with in silico modeling showing that the removal of structural homotopic connections produces a nearly complete loss of inter-hemispheric FC (Messé et al, 2014) . In fact, recent work showed that inter-hemispheric structural connectivity is damaged in stroke, and that patterns of structural disconnection correlate with UFC alterations (Griffis et al, 2019, Griffis et al, 2020 .…”

Section: Granger Causality Analysessupporting

confidence: 81%

Stroke-related alterations in inter-areal communication

Allegra

Favaretto

Metcalf

et al. 2021

Preprint

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Neuroimaging and neurological studies suggest that stroke is a brain network syndrome. While causing local ischemia and cell damage at the site of injury, stroke strongly perturbs the functional organization of brain networks at large. Critically, functional connectivity abnormalities parallel both behavioral deficits and functional recovery across different cognitive domains. However, the reasons for such relations remain poorly understood. Here, we tested the hypothesis that alterations in inter-areal communication underlie stroke-related modulations in functional connectivity (FC). To this aim, we used resting-state fMRI and Granger causality analysis to quantify information transfer between brain areas and its alteration in stroke. Two main large-scale anomalies were observed in stroke patients. First, inter-hemispheric information transfer was strongly decreased with respect to healthy controls. Second, information transfer within the affected hemisphere, and from the affected to the intact hemisphere was reduced. Both anomalies were more prominent in resting-state networks related to attention and language, and they were correlated with impaired performance in several behavioral domains. Overall, our results support the hypothesis that stroke perturbs inter-areal communication within and across hemispheres, and suggest novel therapeutic approaches aimed at restoring normal information flow.SIGNIFICANCE STATEMENTA thorough understanding of how stroke perturbs brain function is needed to improve recovery from the severe neurological syndromes affecting stroke patients. Previous resting-state neuroimaging studies suggested that interaction between hemispheres decreases after stroke, while interaction between areas of the same hemisphere increases. Here, we used Granger causality to reconstruct information flows in the brain at rest, and analyze how stroke perturbs them. We showed that stroke causes a global reduction of inter-hemispheric communication, and an imbalance between the intact and the affected hemisphere: information flows within and from the latter are impaired. Our results may inform the design of stimulation therapies to restore the functional balance lost after stroke.

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“…Instead, we observed a longer inter-hemispheric delay between slow-wave negative peaks in callosotomized patients, which is consistent with the involvement of polysynaptic propagation pathways possibly including cortico-subcortico-cortical loops ( Timofeev and Steriade, 1996 ). Additional mechanisms underlying residual bilateral slow waves in callosotomized patients may include direct subcortico-cortical recruitment processes ( Siclari et al, 2014 ; Bernardi et al, 2018 ) and/or the involvement of anterior and posterior commissures ( Mancuso et al, 2019 ), which were relatively spared in all the CP individuals. Interestingly, a similar change in inter-hemispheric delay was not observed for the positive peak occurring at the transition into the up-state.…”

Section: Discussionmentioning

confidence: 99%

Integrity of Corpus Callosum Is Essential for the Cross-Hemispheric Propagation of Sleep Slow Waves: A High-Density EEG Study in Split-Brain Patients

et al. 2020

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The slow waves of non-rapid eye movement (NREM) sleep reflect experience-dependent plasticity and play a direct role in the restorative functions of sleep. Importantly, slow waves behave as traveling waves, and their propagation is assumed to occur through cortico-cortical white matter connections. In this light, the corpus callosum (CC) may represent the main responsible for cross-hemispheric slow-wave propagation. To verify this hypothesis, we performed overnight high-density (hd)-EEG recordings in five patients who underwent total callosotomy due to drug-resistant epilepsy (CPs; two females), in three noncallosotomized neurologic patients (NPs; two females), and in a sample of 24 healthy adult subjects (HSs; 13 females). In all CPs slow waves displayed a significantly reduced probability of cross-hemispheric propagation and a stronger interhemispheric asymmetry. In both CPs and HSs, the incidence of large slow waves within individual NREM epochs tended to differ across hemispheres, with a relative overall predominance of the right over the left hemisphere. The absolute magnitude of this asymmetry was greater in CPs relative to HSs. However, the CC resection had no significant effects on the distribution of slow-wave origin probability across hemispheres. The present results indicate that CC integrity is essential for the crosshemispheric traveling of slow waves in human sleep, which is in line with the assumption of a direct relationship between white matter integrity and slow-wave propagation. Our findings also revealed a residual cross-hemispheric slow-wave propagation that may rely on alternative pathways, including cortico-subcortico-cortical loops. Finally, these data indicate that the lack of the CC does not lead to differences in slow-wave generation across brain hemispheres.

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Brain functional connectivity in individuals with callosotomy and agenesis of the corpus callosum: A systematic review

Cited by 36 publications

References 207 publications

Physical activity is positively related to local functional connectivity in adolescents’ brains

Physical activity is positively related to local functional connectivity in adolescents’ brains

Stroke-related alterations in inter-areal communication

Integrity of Corpus Callosum Is Essential for the Cross-Hemispheric Propagation of Sleep Slow Waves: A High-Density EEG Study in Split-Brain Patients

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