Brain functional connectivity network breakdown and restoration in blindness

Bola, Michał; Gall, Carolin; Moewes, Christian; Fedorov, A.; Hinrichs, Hermann; Sabel, Bernhard A.

doi:10.1212/wnl.0000000000000672

Cited by 110 publications

(121 citation statements)

References 41 publications

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“…We have recently shown that in patients with vision loss caused by pre-chiasmatic lesions spatial patterns of functional connectivity are impaired (Bola et al, 2014). Specifically, we observed that vision loss was associated with impaired synchronization in the high-alpha band .…”

Section: Introductionmentioning

confidence: 73%

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Disturbed temporal dynamics of brain synchronization in vision loss

Bola

Gall

Sabel

2015

Cortex

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Section: Introductionmentioning

confidence: 73%

“…retinal and/or optic-nerve) visual system damage and 13 control subjects that had no neurological dysfunctions. Their data were already analyzed by different methods and published elsewhere (Bola et al, 2014).…”

Section: Subjectsmentioning

confidence: 99%

Disturbed temporal dynamics of brain synchronization in vision loss

Bola

Gall

Sabel

2015

Cortex

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“…Therefore, it is speculated that vision loss in the blind is caused not only by primary tissue damage but also by breakdown of synchronization in brain networks. 48 In addition, transorbital ES in patients with optic nerve damage showed significant increases in detection ability, visual field, and visual acuity. 49e52 All three published studies on the use of transpalpebral ES were performed in patients with AMD (Table 3).…”

Section: Transorbital and Transpalpebral Es In Clinical Trialsmentioning

confidence: 96%

Electrical Stimulation as a Means for Improving Vision

Sehic

Guo

Cho

et al. 2016

The American Journal of Pathology

138

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Evolving research has provided evidence that noninvasive electrical stimulation (ES) of the eye may be a promising therapy for either preserving or restoring vision in several retinal and optic nerve diseases. In this review, we focus on minimally invasive strategies for the delivery of ES and accordingly summarize the current literature on transcorneal, transorbital, and transpalpebral ES in both animal experiments and clinical studies. Various mechanisms are believed to underlie the effects of ES, including increased production of neurotrophic agents, improved chorioretinal blood circulation, and inhibition of proinflammatory cytokines. Different animal models have demonstrated favorable effects of ES on both the retina and the optic nerve. Promising effects of ES have also been demonstrated in clinical studies; however, all current studies have a lack of randomization and/or a control group (sham). There is thus a pressing need for a deeper understanding of the underlying mechanisms that govern clinical success and optimization of stimulation parameters in animal studies. In addition, such research should be followed by large, prospective, clinical studies to explore the full potential of ES. Through this review, we aim to provide insight to guide future research on ES as a potential therapy for improving vision. (Am J Pathol 2016 http://dx

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“…There are also ongoing clinical trials about this therapy in non-arteritic anterior ischemic optic neuropathy (NA_AION) and traumatic optic neuropathy (TON) [4]. Another study performed for 10 days using lid electrodes and transorbital stimulation instead of transcorneal impulses in optic neuropathies resulted in an average of 25% improvement in VF defects [5]. In this study, alternating current therapy was applied through the eyelids.…”

Section: Introductionmentioning

confidence: 99%

TES in optic neuropathies and RP

Kayabasi¹

2017

New Front Ophthalmol

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Objective: Aim was to achieve improvement in vision and visual fields in optic neuropathies and retinitis pigmentosa (RP) by transcorneal electrical stimulation (TES).Methods: 20 patients with non-arteritic anterior ischemic optic neuropathy, 10 patients with traumatic optic neuropathy and 10 with RP were stimulated using different protocols for optic neuropathies and RP. Patients with optic neuropathy were treated by TES 2 months after the acute event.Results: In all groups, improvement both in vision and visual fields were achieved. The average visual acuity improvement in all groups was 2 Snellen lines. Visual field improvements after 10 days of TES were documented. Changes before and after treatment in Mean Deviation was statistically significant (P< 0,001).Conclusion: TES may be considered as a safe and effective treatment in certain optic neuropathies and RP.

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Brain functional connectivity network breakdown and restoration in blindness

Cited by 110 publications

References 41 publications

Disturbed temporal dynamics of brain synchronization in vision loss

Disturbed temporal dynamics of brain synchronization in vision loss

Electrical Stimulation as a Means for Improving Vision

TES in optic neuropathies and RP

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