Brain Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study before and after Thyroid Hormone Replacement Therapy

Bauer, Michael; Silverman, Daniel; Schlagenhauf, Florian; London, Edythe D.; Geist, Cheri; Herle, Katja Van; Rasgon, Natalie; Martinez, Daniel A.; Miller, Karen J.; Herle, Andre Van; Berman, Steven M.; Phelps, Michael E.; Whybrow, Peter C.

doi:10.1210/jc.2008-2235

Cited by 127 publications

(85 citation statements)

References 20 publications

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“…In this study, we found that in treated hypothyroid patients, QOL was not related to the serum levels of TSH, FT 4 or T 3 . This reinforces results from other studies, in which no correlation between QOL and thyroid parameters could be found.…”

Section: Discussionmentioning

confidence: 49%

“…In a study in Another aspect in the treatment of hypothyroidism is that serum TH levels may not represent TH levels in different tissues. In a study by Escobar-Morreale et al (16) in hypothyroid rats, no single dose of T 4 or T 3 could restore euthyroidism in all tissues at the same time, probably because of varying expression and function of TH transporters and deiodinases. Sex hormone binding globulin (SHBG) is known to be a marker of hepatic TH state (17) and could be a useful parameter of TH status at tissue level.…”

Section: Introductionmentioning

confidence: 93%

“…The symptoms of hypothyroidism vary widely and are related to a decreased function of the brain, muscles, heart and kidney (3,4,5,6,7,8). Restoration of these functions is achieved by treatment with levothyroxine (L-T 4 ) (3,5,8), which markedly improves the signs and symptoms of hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

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Quality of life in patients with primary hypothyroidism related to BMI

Kelderman-Bolk

Visser

Tijssen

et al. 2015

European Journal of Endocrinology

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Objective: Many patients treated for primary hypothyroidism have an unexplained reduced quality of life (QOL). We studied the relation between QOL and various parameters in treated hypothyroid patients. Design and methods: QOL analysis was done in 90 consecutive patients (77.8% females) treated for primary hypothyroidism. QOL was measured by the questionnaires Short-Form 36, Hospital Anxiety and Depression Scale and MFI20. Post hoc analysis was performed on the relation of QOL at baseline and BMI, thyroid hormones and other serum values. QOL in patients was also compared to the general population. Results: QOL was decreased compared to the general population. We found an inverse relationship between QOL and BMI. A relationship between QOL and serum thyroid parameters or auto-antibodies could not be found. Higher sex hormone binding globulin (SHBG) levels corresponded with a better QOL, which is explained by the negative association of SHBG with body weight and BMI. Conclusions: A decreased QOL in hypothyroid patients on thyroxine treatment is related to a higher body weight (BMI). Weight gain needs more attention in the treatment of hypothyroidism.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 93%

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Quality of life in patients with primary hypothyroidism related to BMI

Kelderman-Bolk

Visser

Tijssen

et al. 2015

European Journal of Endocrinology

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“…Many PET studies were based on a region-of-interest approach that examined select regions originally reported by earlier studies. 19,24,25 The region-of-interest method requires that regions be manually delineated, a subjective and technically laborious process for which operators must be rigorously trained.…”

Section: Discussionmentioning

confidence: 99%

Reversible Changes in Brain Glucose Metabolism Following Thyroid Function Normalization in Hyperthyroidism

Miao¹,

Zhang²,

Guan³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Patients with hyperthyroidism frequently present with regional cerebral metabolic changes, but the consequences of endocrine-induced brain changes after thyroid function normalization are unclear. We hypothesized that the changes of regional cerebral glucose metabolism are related to thyroid hormone levels in patients with hyperthyroid, and some of these changes can be reversed with antithyroid therapy.

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“…Relatively few previous functional neuroimaging studies have investigated the neural correlates of mood dysfunction in patients with hypothyroidism (Bauer et al 2009;Constant et al 2001;Nagamachi et al 2004;Schraml et al 2006;Zhu et al 2006), and these studies reported cerebral hypoperfusion as the most consistent finding (Bauer et al 2009;Constant et al 2001;Forchetti et al 1997;Kinuya et al 1999;Krausz et al 2007;Krausz et al 2004;Nagamachi et al 2004;Schraml et al 2006). In a subgroup of patients, this hypoperfusion subsided after thyroid replacement therapy (Bauer et al 2009). Thus, the mechanisms underlying the interactions between thyroid function, brain metabolism, and mood remain to be clarified.…”

Section: Introductionmentioning

confidence: 96%

Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls

2013

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RationaleThyroid hormones and their interactions with catecholamines play a potentially important role in alterations of mood and cognition. ObjectivesThis study aimed to examine the neurobiological effects of catecholamine depletion on thyroid hormones by measuring endocrine and cerebral metabolic function in unmedicated subjects with remitted MDD (RMDD) and in healthy controls. MethodsThis was a randomized, placebo-controlled, and double-blind crossover trial that included 15 unmedicated RMDD subjects and 13 healthy control subjects. The participants underwent two 3-day-long sessions at 1-week intervals; each participant was randomly administered oral α-methyl-para-tyrosine (AMPT) in one session (catecholamine depletion) and an identical capsule containing hydrous lactose (sham depletion) in the other session prior to a [18 F]-fluorodeoxyglucose positron emission tomography scan ( 18 FDG-PET). ResultsSerum concentrations of free T3 (FT3), free T4 (FT4), and TSH were obtained and assessed with respect to their relationship to regional cerebral glucose metabolism. Both serum FT3 (P = 0.002) and FT4 (P = 0.0009) levels were less suppressed after catecholamine depletion compared with placebo treatment in the entire study sample. There was a positive association between both FT3 (P = 0.0005) and FT4 (P = 0.002) and depressive symptoms measured using the MADRS. The relative elevation in FT3 level was correlated with a decrease in regional glucose metabolism in the right dorsolateral prefrontal cortex (rDLPFC; P < 0.05, corrected).Homan et al.2 ConclusionsThis study provided evidence of an association between a thyroid-catecholamine interaction and mood regulation in the rDLPFC.

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Brain Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography Study before and after Thyroid Hormone Replacement Therapy

Cited by 127 publications

References 20 publications

Quality of life in patients with primary hypothyroidism related to BMI

Quality of life in patients with primary hypothyroidism related to BMI

Reversible Changes in Brain Glucose Metabolism Following Thyroid Function Normalization in Hyperthyroidism

Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls

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