2022
DOI: 10.1016/j.brainresbull.2022.02.004
|View full text |Cite
|
Sign up to set email alerts
|

Brain–gut–microbiota axis in depression: A historical overview and future directions

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

2
109
0
6

Year Published

2022
2022
2024
2024

Publication Types

Select...
10

Relationship

2
8

Authors

Journals

citations
Cited by 208 publications
(117 citation statements)
references
References 223 publications
2
109
0
6
Order By: Relevance
“…It is also of interest to examine whether pain might affect depression-like behaviors in CIA mice or ABX-treated mice after FMT from RA patients. Third, the recent studies demonstrated the role of subdiaphragmatic vagus nerve on the depression-like behaviors in ABX-treated mice after FMT of depression-related microbes [ 20 , 22 , 24 , 55 , 56 ]. Further study on the role of subdiaphragmatic vagus nerve on depression-like behaviors in rodents after FMT from RA patients is needed.…”
Section: Discussionmentioning
confidence: 99%
“…It is also of interest to examine whether pain might affect depression-like behaviors in CIA mice or ABX-treated mice after FMT from RA patients. Third, the recent studies demonstrated the role of subdiaphragmatic vagus nerve on the depression-like behaviors in ABX-treated mice after FMT of depression-related microbes [ 20 , 22 , 24 , 55 , 56 ]. Further study on the role of subdiaphragmatic vagus nerve on depression-like behaviors in rodents after FMT from RA patients is needed.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence suggests that alterations in the gut microbiota and microbe-derived metabolites play a key role in the pathophysiology of depression via the brain–gut–microbiota axis ( 41 ). It was found that CUMS treatment induced changes in the β diversity of gut microbiota and up-regulation of plasma intestinal mucosal barrier markers, ET and DAO, resulting in depression-like behavioral changes, which also supports the theory that the brain-gut axis is associated with depression.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have proposed that the common pathways of the MBG axis are the immune system, endocrine system, neurotransmitter, and HPA axis. The immune system is one of most common ways in the MGB axis [ 47 , 48 ]. IL-6 and IL-1β are pro-inflammatory factors while IL-10 reduces inflammatory response by downregulating IL-1 and TNF-α levels [ 49 ].…”
Section: Discussionmentioning
confidence: 99%