Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling

Choi, Ji‐Kyung; Chen, Y. Iris; Hamel, Edith; Jenkins, Bruce G.

doi:10.1016/j.neuroimage.2005.10.029

Cited by 185 publications

(248 citation statements)

References 60 publications

Supporting

Mentioning

224

Contrasting

Unclassified

Order By: Relevance

“…Cerebral microvessels express DA receptors (Choi et al, 2006), and the opposing effects of D1 and D2 receptor antagonists on L-DOPA-induced angiogenesis in this study are in keeping with the reported roles of D2 and D1 receptors in endothelial cell biology. Indeed, DA inhibits endothelial proliferation and vessel growth through activation of D2 receptors (Basu et al, 2001;Cristina et al, 2005;Gomez et al, 2006;Sarkar et al, 2004).…”

Section: Discussionsupporting

confidence: 89%

“…Indeed, the D1 agonist SKF38393 causes vessel dilatation, whereas the D1 antagonist SCH23390 causes constriction of cerebral pial arterioles in vivo (Edvinsson et al, 1985). Furthermore, D1-specific agonists induce large increases in relative cerebral blood volume (rCBV) in regions of high DA receptor abundance, whereas the D1 receptor antagonist SCH23390 prevents this hemodynamic response (Choi et al, 2006). All these findings indicate that the brain microvasculature is heavily affected by the pharmacotherapy of PD and that it may influence its outcome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Lindgren

Ohlin

Cenci

2009

Neuropsychopharmacol

View full text Add to dashboard Cite

Angiogenesis occurs in the brains of Parkinson's disease patients, but the effects of dopamine replacement therapy on this process have not been examined. Using rats with 6-hydroxydopamine lesions, we have compared angiogenic responses induced in the basal ganglia by chronic treatment with either L-DOPA, or bromocriptine, or a selective D1 receptor agonist (SKF38393). Moreover, we have asked whether L-DOPA-induced angiogenesis can be blocked by co-treatment with either a D1-or a D2 receptor antagonist (SCH23390 and eticlopride, respectively), or by an inhibitor of extracellular signal-regulated kinases 1 and 2 (ERK1/2) (SL327). L-DOPA, but not bromocriptine, induced dyskinesia, which was associated with endothelial proliferation, upregulation of immature endothelial markers (nestin) and downregulation of endothelial barrier antigen in the striatum and its output structures. At a dose inducing dyskinesia (1.5 mg/kg/day), SKF38393 elicited angiogenic changes similar to L-DOPA. Antagonism of D1-but not D2 class receptors completely suppressed both the development of dyskinesia and the upregulation of angiogenesis markers. In fact, L-DOPA-induced endothelial proliferation was markedly exacerbated by low-dose D2 antagonism (0.01 mg/kg eticlopride). Inhibition of ERK1/2 by SL327 attenuated L-DOPA-induced dyskinesia and completely inhibited all markers of angiogenesis. These results highlight the specific link between treatment-induced dyskinesias and microvascular remodeling in the dopamine-denervated brain. L-DOPA-induced angiogenesis requires stimulation of D1 receptors and activation of ERK1/2, whereas the stimulation of D2 receptors seems to oppose this response.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Lindgren

Ohlin

Cenci

2009

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…26 Although, little is known about this unique hemodynamic regulation in the striatum, activation of D 2 -like receptors has been shown to induce striatal CBV decreases. 27 Injection of D 2 -like receptor antagonist also reduced the striatal negative fMRI responses evoked by noxious forepaw stimuli. 5,6,10 These results, in line with an earlier report, 28 implied that dopamine and its receptors can regulate regional microcirculation.…”

Section: Neurovascular Responses In the Striatummentioning

confidence: 95%

Imaging Neurovascular Function and Functional Recovery after Stroke in the Rat Striatum Using Forepaw Stimulation

Shih

Huang

Lai

et al. 2014

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Negative functional magnetic resonance imaging (fMRI) response in the striatum has been observed in several studies during peripheral sensory stimulation, but its relationship between local field potential (LFP) remains to be elucidated. We performed cerebral blood volume (CBV) fMRI and LFP recordings in normal rats during graded noxious forepaw stimulation at nine stimulus pulse widths. Albeit high LFP-CBV correlation was found in the ipsilateral and contralateral sensory cortices (r ¼ 0.89 and 0.95, respectively), the striatal CBV responses were neither positively, nor negatively correlated with LFP (r ¼ 0.04), demonstrating that the negative striatal CBV response is not originated from net regional inhibition. To further identify whether this negative CBV response can serve as a marker for striatal functional recovery, two groups of rats (n ¼ 5 each) underwent 20-and 45-minute middle cerebral artery occlusion (MCAO) were studied. No CBV response was found in the ipsilateral striatum in both groups immediately after stroke. Improved striatal CBV response was observed on day 28 in the 20-minute MCAO group compared with the 45-minute MCAO group (Po0.05). This study shows that fMRI signals could differ significantly from LFP and that the observed negative CBV response has potential to serve as a marker for striatal functional integrity in rats.

show abstract

“…Although BOLD fMRI cannot measure neurotransmitter activity directly, greater anticipatory activity in this network posttreatment may indicate a recovery of dopamine-related activity and endogenous response to non-drug rewards (Choi et al, 2006). Some evidence links dopamine D2 receptor availability with monetary expectation response in CD (Asensio et al, 2010), suggesting that resting availability of …”

Section: Within-group CD Differencesmentioning

confidence: 99%

Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery

Balodis

Kober

Worhunsky

et al. 2016

Neuropsychopharmacol

View full text Add to dashboard Cite

Although reward processing appears altered in addiction, few studies track neurofunctional changes following treatment or relate these to measures of reduced drug use. The current study examined neurofunctional alterations in reward processing in cocaine dependence (CD) pretreatment and posttreatment to determine whether these changes relate to clinically meaningful outcome indicators. Treatmentseeking CD outpatients (N = 29) underwent functional magnetic resonance imaging while performing a monetary incentive delay task (MIDT) pretreatment and posttreatment. The MIDT parses anticipatory from outcome phases of reward/loss processing. Abstinence indicators (negative urines, days abstinent from cocaine during follow-up) were collected throughout treatment and up to 1 year later. Healthy control (HC) participants (N = 28) were also scanned twice with the MIDT. Relative to pretreatment, at posttreatment CD participants demonstrated increased anticipatory reward activity in the midbrain, thalamus, and precuneus (p FWE o0.05). Increased midbrain activity correlated with cocaine abstinence during the 1-year follow-up. Ventral striatal (VS) activity during loss anticipation correlated negatively with negative urine screens. HC group test-retest results showed decreased ventromedial prefrontal cortex activity during winning outcomes. CD-HC group-by-time differences revealed increased left inferior frontal gyrus activity in the CD group during anticipatory phases at posttreatment. In CD participants, increased posttreatment activity in dopamine-innervated regions suggests lowered thresholds in anticipatory signaling for non-drug rewards. Midbrain and VS responses may represent biomarkers associated with CD abstinence. Abstinence-related neurobiological changes occur in similar regions implicated during active use and may possibly be used to track progress during short-and long-term recovery.

show abstract

Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling

Cited by 185 publications

References 60 publications

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Differential Involvement of D1 and D2 Dopamine Receptors in L-DOPA-Induced Angiogenic Activity in a Rat Model of Parkinson's Disease

Imaging Neurovascular Function and Functional Recovery after Stroke in the Rat Striatum Using Forepaw Stimulation

Neurofunctional Reward Processing Changes in Cocaine Dependence During Recovery

Contact Info

Product

Resources

About