Brain imaging correlates of cue-induced cocaine craving

O’Brien, C.P.; Childress, AR; McElgin, William; Mozley, P. David; Fitzgerald, Jacklynn M.; Reivich, Martin

doi:10.1016/0006-3223(96)83985-0

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“…Improvements in the spatial resolution of current scanning methods will have to conÞrm that this response involved mediodorsal thalamic areas. Therefore, together with previous Þndings in animals (Robledo and Koob 1993;Whitelaw et al 1996;Weissenborn et al 1997;Caine et al, unpublished observations) and humans (Modell et al 1990;OBrien et al 1996;Volkow et al 1996Volkow et al , 1997, the present results o¤er further support for the hypothesis that drug-seeking and drug-taking behaviour are not mediated by isolated structures of the reward pathway. Instead, the entire corticostriatopallidal circuitry, as well as structures projecting to it, may be involved in modulating aspects of drug and alcohol addiction.…”

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confidence: 82%

Excitotoxic lesions of the mediodorsal thalamic nucleus attenuate intravenous cocaine self-administration

et al. 1998

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The present experiments investigated the effects of excitotoxic, axon-sparing lesions of the mediodorsal nucleus of the thalamus (MD) on locomotor activity and i.v. cocaine self-administration. Infusion of quinolinic acid into the MD using a glass micropipette produced well-defined neuronal loss restricted to medial and lateral portions of the MD, sparing adjacent areas such as the lateral habenula and paraventricular thalamic nucleus. MD lesions resulted in delayed habituation to activity cages. In addition, lesioned rats self-administered significantly smaller amounts of cocaine than controls during a 14-day acquisition period, and showed attenuated responding for cocaine doses on the descending limb of the dose-effect function. Since typical titrating patterns of responding were maintained in lesioned rats, and responding on the inactive lever did not differ from sham-operated animals, these present results indicate an enhanced sensitivity to the reinforcing effects of response-contingent cocaine in rats with excitotoxic lesions of the MD.

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