Brain imaging findings in COVID-19: What do we know so far?

Abstract

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Superficial Cerebral Venous Thrombosis and Intracerebral Hematoma in a 48-Year-Old Man with SARS-CoV-2 Infection: A Case Report

“…The pathophysiology of the hypercoagulable state in SARS-CoV-2 infection is multifactorial: it involves (i) an increase in acute-phase reactants (cytokine storm), (ii) endothelial damage sustained due to SARS-CoV-2, and (iii) diffuse microvascular injury with resulting thrombosis [ 6 ]. These findings are supported in a study by Md Noh [ 7 ], who found that patients with COVID-19 show prolonged prothrombin time, as well as increased D-dimer levels and low-normal platelet counts. While thromboembolic complications are relatively uncommon in COVID-19, it is important to keep them in mind because of their potential severity and the diversity of clinical presentations.…”

COVID-19 as triggering co-factor for cortical cerebral venous thrombosis?

“…The COVID-19 is caused by the SARS-CoV-2. This coronavirus activates inflammatory and thrombotic pathways by binding the angiotensin-converting enzyme 2 receptors of endothelial cells, leading to an endotheliitis and a diffuse procoagulant state [7]. Our case suggests that the cerebral venous system can also be affected by this pathologic process.…”

“…This is however, to our knowledge, the first description of a case with an associated cortical CVT. Other brain imaging abnormalities (arterial stroke or images compatible with acute disseminated encephalomyelitis) have been described [6]. The COVID-19 is caused by the SARS-CoV-2.…”

“…Several observational studies have shown a high proportion of thromboembolic events in patients infected by the agent [9][10][11]. Varga et al established evidences for direct viral infection of the endothelial cells with local accumulation of inflammatory cells [7]. The authors suggested that the SARS-CoV-2 could facilitate the development of endotheliitis in several organs resulting in a global procoagulant state [7].…”

Diagnostic value of chest computed tomography imaging for COVID-19 based on reverse transcription-polymerase chain reaction: a meta-analysis

“…Coronavirus disease 2019 (COVID-19) is an acute infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is primarily characterized by pulmonary inflammatory lesions. It can also cause damage to the digestive system [ 1 – 3 ], nervous system [ 4 , 5 ], urinary system [ 6 ] and other systemic organs, with corresponding clinical symptoms. COVID-19 was identified as the health emergency of national concern by World Health Organization on 30 January, 2020 since its initial detection in December 2019 [ 7 ].…”