Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

Liu, Fang; You, Yun; Li, Xiaosu; Ma, Tong; Nie, Yanzhen; Wei, Bin; Li, Tiejun; Lin, Hua; Yang, Zhengang

doi:10.1523/jneurosci.0201-09.2009

Cited by 103 publications

(110 citation statements)

References 59 publications

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“…The implication of heterogeneous brain stem cells for tissue regeneration is not well understood. However, the limited availability or depletion of specific stem and progenitor cells could impair the regeneration of specific brain cell lineages (Liu et al, 2009;Encinas et al, 2011;Barbosa et al, 2015). Teleost fish have a much greater ability to regenerate CNS injuries than mammals (Becker et al, 1997;Kaslin et al, 2008;Reimer et al, 2008;Kroehne et al, 2011;Baumgart et al, 2012;Kishimoto et al, 2012;Kizil et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

et al. 2017

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Zebrafish can regenerate after brain injury, and the regenerative process is driven by resident stem cells. Stem cells are heterogeneous in the vertebrate brain, but the significance of having heterogeneous stem cells in regeneration is not understood. Limited availability of specific stem cells might impair the regeneration of particular cell lineages. We studied regeneration of the adult zebrafish cerebellum, which contains two major stem and progenitor cell types: ventricular zone and neuroepithelial cells. Using conditional lineage tracing we demonstrate that cerebellar regeneration depends on the availability of specific stem cells. Radial glia-like cells are thought to be the predominant stem cell type in homeostasis and after injury. However, we find that radial glia-like cells play a minor role in adult cerebellar neurogenesis and in recovery after injury. Instead, we find that neuroepithelial cells are the predominant stem cell type supporting cerebellar regeneration after injury. Zebrafish are able to regenerate many, but not all, cell types in the cerebellum, which emphasizes the need to understand the contribution of different adult neural stem and progenitor cell subtypes in the vertebrate central nervous system.

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Section: Introductionmentioning

confidence: 99%

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

et al. 2017

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“…Notably, Inta and Gass (2015) reported ECT-triggered neurogenesis in striatal and frontal brain regions following ECT in a rat model suggesting that cell proliferation extends beyond the hippocampus. Others (Liu et al, 2009) have also reported increased subventricular zone neuroblast cell proliferation to striatal areas following seizures. Further, ECT-related structural neuroplasticity is shown in the amygdala (Tendolkar et al, 2013;Joshi et al, 2015).…”

Section: Discussionmentioning

confidence: 89%

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Wade

Joshi

Njau

et al. 2016

Neuropsychopharmacol

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Patients with major depression show reductions in striatal and paleostriatal volumes. The functional integrity and connectivity of these regions are also shown to change with antidepressant response. Electroconvulsive therapy (ECT) is a robust and rapidly acting treatment for severe depression. However, whether morphological changes in the dorsal and ventral striatum/pallidum relate to or predict therapeutic response to ECT is unknown. Using structural MRI, we assessed cross-sectional effects of diagnosis and longitudinal effects of ECT for volume and surface-based shape metrics of the caudate, putamen, pallidum, and nucleus accumbens in 53 depressed patients (mean age: 44.1 years, 13.8 SD; 52% female) and 33 healthy controls (mean age: 39.3 years, 12.4 SD; 57% female). Patients were assessed before ECT, after their second ECT, and after completing an ECT treatment index. Controls were evaluated at two time points. Support vector machines determined whether morphometric measures at baseline predicted ECT-related clinical response. Patients showed smaller baseline accumbens and pallidal volumes than controls (Po0.05). Increases in left putamen volume (Po0.03) occurred with ECT. Global increases in accumbens volume and local changes in pallidum and caudate volume occurred in patients defined as treatment responders. Morphometric changes were absent across time in controls. Baseline volume and shape metrics predicted overall response to ECT with up to 89% accuracy. Results support that ECT elicits structural plasticity in the dorsal and ventral striatum/pallidum. The morphometry of these structures, forming key components of limbic-cortical-striatal-pallidal-thalamic circuitry involved in mood and emotional regulation, may determine patients likely to benefit from treatment.

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“…The main differences between germinal-layer-derived and parenchymal neurogenesis are listed in Table 2. It has been proposed that some parenchymal newborn neurons have a transient existence (Gould et al 2001;Luzzati et al 2011), and their fate and role remain unknown (Arvidsson et al 2002;Chen et al 2004;Liu et al 2009;Ohira et al 2010;Bonfanti and Peretto 2011;Luzzati et al 2011).…”

Section: Parenchymal Neurogenesismentioning

confidence: 99%

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

Feliciano

Bordey

Bonfanti

2015

Cold Spring Harb Perspect Biol

106

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Two decades after the discovery that neural stem cells (NSCs) populate some regions of the mammalian central nervous system (CNS), deep knowledge has been accumulated on their capacity to generate new neurons in the adult brain. This constitutive adult neurogenesis occurs throughout life primarily within remnants of the embryonic germinal layers known as "neurogenic sites." Nevertheless, some processes of neurogliogenesis also occur in the CNS parenchyma commonly considered as "nonneurogenic." This "noncanonical" cell genesis has been the object of many claims, some of which turned out to be not true. Indeed, it is often an "incomplete" process as to its final outcome, heterogeneous by several measures, including regional location, progenitor identity, and fate of the progeny. These aspects also strictly depend on the animal species, suggesting that persistent neurogenic processes have uniquely adapted to the brain anatomy of different mammals. Whereas some examples of noncanonical neurogenesis are strictly parenchymal, others also show stem cell niche-like features and a strong link with the ventricular cavities. This work will review results obtained in a research field that expanded from classic neurogenesis studies involving a variety of areas of the CNS outside of the subventricular zone (SVZ) and subgranular zone (SGZ). It will be highlighted how knowledge concerning noncanonical neurogenic areas is still incomplete owing to its regional and species-specific heterogeneity, and to objective difficulties still hampering its full identification and characterization.

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Brain Injury Does Not Alter the Intrinsic Differentiation Potential of Adult Neuroblasts

Cited by 103 publications

References 59 publications

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

Effect of Electroconvulsive Therapy on Striatal Morphometry in Major Depressive Disorder

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

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