Brain Magnetic Resonance Imaging Findings in Infantile Spasms

Muthaffar, Osama

doi:10.3390/neurolint14010021

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…In patients with positive family history, abnormal physical neurological examinations, or other clinical suspicions that include dysmorphic features and congenital anomalies, it is recommended to perform an MRI examination even if the EEG examination was normal. According to the literature, MRI is one of the integral modalities in evaluating seizure etiology [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The Spectrum of MRI and Electrographic Findings in Pediatric Patients With Seizures: A Retrospective Tertiary Care Center Study

Alyoubi¹,

Daghistani²,

Albogmi³

et al. 2023

Cureus

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Background Seizures constitute a serious public health concern, especially in pediatric patients. They are among the most prevalent medical issues affecting children. Magnetic resonance imaging (MRI) is a widely used imaging modality to evaluate, assess, and follow up on brain abnormalities. Objectives The purpose of the study is to explore the clinical findings of pediatric patients with seizures and their associated findings on MRI examinations. Material and methods A retrospective cohort study was conducted between 2021 and 2022 at King Abdulaziz University Hospital (KAUH). A total of 171 pediatric patients (ages 1-14 years old) who had seizures and underwent brain MRI examinations were included in the study. The mean age of the group was two years. Results Focal seizures represented the majority of seizure types in 62 (60.2%) patients compared to 42 patients who presented with generalized seizures and 67 patients who presented with normal findings based on magnetic resonance imaging (MRI) analysis. The most common finding in imaging was the presence of developmental anomalies, which were found in 31 (18.5%) patients. This was followed by hypoxic-ischemic injury in 12 patients, vascular abnormalities in 10 patients, inherited metabolic disorders in nine patients, and infection-related findings in six patients. Conclusion MRI has an invaluable role in managing pediatric patients with seizures. Accurate diagnosis of patients is an essential step for delivering proper care to patients. MRI is considered the main imaging modality to establish a correct diagnosis and thereby improve prognosis, and electroencephalogram (EEG) should be taken into account during standard neurodiagnostic testing.

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Section: Discussionmentioning

confidence: 99%

The Spectrum of MRI and Electrographic Findings in Pediatric Patients With Seizures: A Retrospective Tertiary Care Center Study

Alyoubi¹,

Daghistani²,

Albogmi³

et al. 2023

Cureus

View full text Add to dashboard Cite

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Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome

Riikonen

2023

Seizure: European Journal of Epilepsy

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Infantile epileptic spasms syndrome: a cohort study of 88 children

Ren,

Zhang,

et al. 2023

Ital J Pediatr

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Background This study aimed to investigate and analyze the risk factors for non-etiology-specific infantile spasms (IS) and unrelieved clinical symptoms after treatment. Methods Eighty-eight children with IS who were treated at our hospital from March 2018 to December 2021 were included in the study. The children were divided into etiology-specific (n = 46) and nonetiology-specific (n = 42) groups, based on the diagnostic results, and remission (n = 45) and nonremission (n = 43) groups, based on clinical outcomes after treatment. The clinical data from patients in the etiology-specific and nonetiology-specific groups and the remission and nonremission groups were compared. Risk factors for non-etiology-specific IS were identified using logistic regression analysis. Results Gender, family history, birth status, and metabolic abnormalities were significantly different between the etiology-specific and non-etiology-specific groups. Gender and metabolic abnormalities were risk factors for nonetiology-specific IS. Family history, birth status, metabolic abnormalities, and brain magnetic resonance imaging were significantly different between the remission and nonremission groups, and different etiologies were risk factors for unrelieved symptoms after treatment. Conclusion The occurrence of nonetiology-specific IS is associated with gender and metabolic abnormalities in children. After medication, unrelieved IS symptoms are associated with etiologies.

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Brain Magnetic Resonance Imaging Findings in Infantile Spasms

Cited by 3 publications

References 32 publications

The Spectrum of MRI and Electrographic Findings in Pediatric Patients With Seizures: A Retrospective Tertiary Care Center Study

The Spectrum of MRI and Electrographic Findings in Pediatric Patients With Seizures: A Retrospective Tertiary Care Center Study

Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome

Infantile epileptic spasms syndrome: a cohort study of 88 children

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