Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients –A preliminary PET study

Kumano, Hiroshi; Ida, Iturou; Oshima, Akihiro; Takahashi, Keisuke; Yuuki, Naoya; Amaki, Makoto; Oriuchi, Noboru; Endo, Keigo; Matsuda, Hiroshi; Murakami, Masahiko

doi:10.1016/j.jpsychires.2006.03.006

Cited by 56 publications

(39 citation statements)

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“…Creatine's elevation in 1 H-MRS has been attributed to altered metabolism (50). Our elevated creatine finding is consistent with altered metabolism, as suggested by earlier studies that found both decreased (4,5,(51)(52)(53) and increased (7,54) basal ganglia/caudate blood flow and glucose metabolism in major depression. Indeed, 31 P-MRS, capable of quantifying nucleoside triphosphates, has further implicated basal ganglia metabolism in major depression (55,56).…”

Section: Creatinesupporting

confidence: 92%

“…In adults with major depression, change in left caudate regional cerebral blood flow correlated with the emergence of depressive symptoms after interruption of paroxetine treatment (65). In cancer patients, increased left caudate glucose metabolism at baseline was associated with depressive symptoms 2 years later compared with patients who did not develop depression (54). Taken together, these findings emphasize the potential role of metabolic probes for early identification of major depressive disorder, perhaps even before the onset of clinical symptoms.…”

Section: Lateralization Of Caudate Metabolic Abnormalities In Major Dmentioning

confidence: 89%

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Lateralized Caudate Metabolic Abnormalities in Adolescent Major Depressive Disorder: A Proton MR Spectroscopy Study

Gabbay

Hess

Liu

et al. 2007

AJP

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Objective-Proton magnetic resonance spectroscopy ( 1 H-MRS) has been increasingly used to examine striatal neurochemistry in adult major depressive disorder. This study extends the use of this modality to pediatric major depression to test the hypothesis that adolescents with major depression have elevated concentrations of striatal choline and creatine and lower concentrations of N-acetylaspartate.Method-Fourteen adolescents (ages 12-19 years, eight female) who had major depressive disorder for at least 8 weeks and a severity score of 40 or higher on the Children's Depression Rating Scale -Revised and 10 healthy comparison adolescents (six female) group-matched for gender, age, and handedness were enrolled. All underwent three-dimensional 3-T 1 H-MRS at high spatial resolution (0.75-cm 3 voxels). Relative levels of choline, creatine, and N-acetylaspartate in the left and right caudate, putamen, and thalamus were scaled into concentrations using phantom replacement, and levels were compared for the two cohorts.Results-Relative to comparison subjects, adolescents with major depressive disorder had significantly elevated concentrations of choline (2.11 mM versus 1.56 mM) and creatine (6.65 mM versus 5.26 mM) in the left caudate. No other neurochemical differences were observed between the groups.Conclusions-These findings most likely reflect accelerated membrane turnover and impaired metabolism in the left caudate. The results are consistent with prior imaging reports of focal and lateralized abnormalities in the caudate in adult major depression.Rates of major depressive disorder rise dramatically in adolescence, with an estimated lifetime prevalence of 15% in adolescents by ages 15-18. Major depression is associated with significant morbidity, including deterioration in academic functioning, increased risk of substance use, and attempted and completed suicides (1,2). Furthermore, adolescent major depression is a strong predictor of major depression in adulthood, which carries its own burden of disadvantage (3). These findings highlight the need for specific neurobiological research in adolescent major depression.Converging lines of evidence suggest that the pathophysiology of depression entails impairment of cellular resilience and neuroplasticity in specific cortical, subcortical, and limbic brain regions. The relationship between the basal ganglia and depression has been inferred from the high comorbidity between depression and Parkinson's disease as well as Huntington's NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript disease, both basal ganglia-related disorders. In addition, morphometric studies (but not all) and functional neuroimaging studies have documented smaller caudate, putamen, and thalamus as well as impaired metabolism and blood flow in the striatum and thalamus in depression (4-10).Proton magnetic resonance spectroscopy ( 1 H-MRS) has provided additional evidence for the involvement of the striatum in adult major depression. 1 H-MRS provides metabolic assay of ne...

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Section: Creatinesupporting

confidence: 92%

Section: Lateralization Of Caudate Metabolic Abnormalities In Major Dmentioning

confidence: 89%

Lateralized Caudate Metabolic Abnormalities in Adolescent Major Depressive Disorder: A Proton MR Spectroscopy Study

Gabbay

Hess

Liu

et al. 2007

AJP

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“…To date, there is a paucity of studies on depressive mood-related brain lesions in CKD patients who do not yet require dialysis. Many investigators have suggested that the depressive mood-related brain lesions in patients with major depression are located in the prefrontal cortex, superior temporal gyrus, cingulate gyrus, amygdala, thalamus, striatum, and so on [14][15][16]. In several reports, diverse, heterogeneous, and confl icting results, showing both increases and discordance in the locations of reduced rCBF, have also been reported [17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

et al. 2008

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“…For example, relative to controls depressed MDD and BD subjects show metabolic activity that appears reduced in the sgACC (Figure 8) (Drevets et al, 1997a(Drevets et al, , 2002aLiotti et al, 2002;Ketter et al, 2001;Kegeles et al, 2003;Kruger et al, 2003;Pizzagalli et al, 2004). These metabolic reductions may predate the onset of clinical symptoms as (Kumano et al, 2006) found that cancer patients who went on to develop depression had lower baseline metabolic rates of the sgACC compared with cancer controls who did not become depressed. However, other studies reported increased metabolic activity in the sgACC in primary (Wu et al, 1999;Mayberg et al, 2000Mayberg et al, , 2005 (Inagaki et al, 2007).…”

Section: Neurophysiological Imaging In Major Depressive and Bipolar Dmentioning

confidence: 98%

Neurocircuitry of Mood Disorders

Price

Drevets

2009

Neuropsychopharmacol

1,400

1,101

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This review begins with a brief historical overview of attempts in the first half of the 20th century to discern brain systems that underlie emotion and emotional behavior. These early studies identified the amygdala, hippocampus, and other parts of what was termed the 'limbic' system as central parts of the emotional brain. Detailed connectional data on this system began to be obtained in the 1970s and 1980s, as more effective neuroanatomical techniques based on axonal transport became available. In the last 15 years these methods have been applied extensively to the limbic system and prefrontal cortex of monkeys, and much more specific circuits have been defined. In particular, a system has been described that links the medial prefrontal cortex and a few related cortical areas to the amygdala, the ventral striatum and pallidum, the medial thalamus, the hypothalamus, and the periaqueductal gray and other parts of the brainstem. A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders.

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Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients –A preliminary PET study

Cited by 56 publications

References 36 publications

Lateralized Caudate Metabolic Abnormalities in Adolescent Major Depressive Disorder: A Proton MR Spectroscopy Study

Lateralized Caudate Metabolic Abnormalities in Adolescent Major Depressive Disorder: A Proton MR Spectroscopy Study

Statistical parametric mapping analysis of the relationship between regional cerebral blood flow and symptom clusters of the depressive mood in patients with pre-dialytic chronic kidney disease

Neurocircuitry of Mood Disorders

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