Brain Metastases and Leptomeningeal Disease

Kumthekar, Priya; Le Rhun, Emilie

doi:10.1212/con.0000000000001354

Cited by 2 publications

References 89 publications

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The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy

Kumthekar,

Blouw,

Corkos

et al. 2024

Front. Oncol.

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IntroductionCNSide is a platform that detects and characterizes tumor cells in the cerebrospinal fluid (CSF) of patients with leptomeningeal disease (LMD). The platform was validated per College of American Pathologists (CAP) and Clinical Laboratories Improvement Amendment (CLIA) guidelines and run as a commercial Laboratory Developed Test (LDT) at Biocept in San Diego, CA. The platform allows CSF tumor cell (CSF-TC) enumeration and biomarker characterization by fluorescent in situ hybridization (FISH). MethodsWe performed a multicenter retrospective chart review of HER2 FISH CNSide test results that were commercially ordered on 26 patients by physicians for LMD breast cancer patients between April 2020 and October 2022.ResultsWe show that HER2 is amplified on CSF tumor cells in 62% (16/26) of LMD breast cancer patients. 10/26 (38%) patients had discordant HER2-positivity between the primary tumor tissue and CSF-TC; of these, 35% (9/26) of the patients displayed HER2 amplification on the CSF-TCs, however were categorized as HER2 negative on the primary tumor. Of the 27% (7/26) patients with a HER2 positive primary tumor, one patient showed a HER2 negative LMD tumor. Two patients, 8% (2/26) had a HER2 equivocal primary tumor; of these, one demonstrated a HER2 negative, and one a HER2 positive LMD tumor. Serial analysis (at least 4 longitudinal tests) of HER2 status of the CSF-TC throughout therapy was available for 14 patients and demonstrated that HER2 status of the LMD changed in 29% (4/14) during their treatment course and impacted care decisions. ConclusionsOur data suggests that CSF-TC HER2 FISH analysis in LMD breast cancer patients may be discordant to the primary tumor sample and the discovery of HER2 positivity in the CSF may open doors to anti-HER2 targeted therapy options for LMD patients.

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The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy

Kumthekar,

Blouw,

Corkos

et al. 2024

Front. Oncol.

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Management of Brain Metastasis in Patients with Metastatic Prostate Cancer

Gulatar Turkoglu,

Agan Yildirim

2024

Current Management of Metastatic Prostate Cancer

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In this section, where the concepts of family and marriage are defined, the importance and history of these concepts, the perspectives of Turkey and other countries on marriage and family, the structural features of the family and its place in society, the functions of the family, and family types are explained in detail. When the concepts and importance of family and marriage are understood and acted upon, couples achieve their goals as happy individuals. Although there are many definitions of marriage and family, in short, marriage is the art of creating a happy family as a result of individuals striving to become ""us"" while preserving their own boundaries and identities. Family is a social structure in which we feel the happiness of belonging, feel safe in every aspect, and learn about life and living together with others. Basic life needs are met within the family, and the longest interaction occurs here. The basic behaviours and life habits that form personality are acquired through this interaction. Family constitutes the first and most important dimension of an individual’s social environment. The child’s upbringing as an individual in accordance with society’s expectations is achieved within the family. In marriages, it is essential for the art of being happy that both men and women have their own spaces and areas to be together.

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Brain Metastases and Leptomeningeal Disease

Cited by 2 publications

References 89 publications

The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy

The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy

Management of Brain Metastasis in Patients with Metastatic Prostate Cancer

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